Microbubbles can be used in combination with ultrasound for local drug delivery, thereby achieving high therapeutic efficacy with limited systemic adverse effects. To produce microbubbles that are stable, effective, and respond uniformly to ultrasound, this thesis aimed to develop a new formulation of microbubbles focusing on the microstructures in the coating. Microstructures, acoustic behavior, and effect were studied using an ultra-high-speed camera coupled to a confocal microscope.
|Award date||11 May 2022|
|Place of Publication||Rotterdam|
|Publication status||Published - 11 May 2022|