Microtubules and cadherins: a neglected partnership

SJ Stehbens, Anna Akhmanova, AS Yap

Research output: Contribution to journalArticleAcademicpeer-review

29 Citations (Scopus)

Abstract

Classical cadherins are fundamental determinants of tissue organization both in health and disease. It has long been recognized that cadherins function in close cooperation with the cytoskeleton, particularly with actin. Less appreciated is the capacity for cadherins to also interact functionally and biochemically with microtubules and their associated proteins. In this review, we aim to highlight the potential for cooperativity between cadherins and microtubules. Cadherins can regulate the organization and dynamics of microtubules through mechanisms such as anchorage of minus ends and cortical capture of plus ends. Such cadherin-induced reorganization of microtubules may then affect cadherin biology by diverse processes that include directed vesicular traffic by microtubule-based motors and regulation of cortical signaling and organization. Ultimately, we hope this will stimulate fresh interest and research to understand a neglected partnership.
Original languageUndefined/Unknown
Pages (from-to)3159-3167
Number of pages9
JournalFrontiers in Bioscience
Volume14
DOIs
Publication statusPublished - 2009

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