Microvasculature Features Derived from Hybrid EPI MRI in Non-Enhancing Adult-Type Diffuse Glioma Subtypes

Fatemeh Arzanforoosh; Sebastian R. van der Voort; Fatih Incekara; Arnaud Vincent; Martin Van den Bent; Johan M. Kros; Marion Smits; Esther A.H. Warnert

doi:10.3390/cancers15072135

Microvasculature Features Derived from Hybrid EPI MRI in Non-Enhancing Adult-Type Diffuse Glioma Subtypes

Fatemeh Arzanforoosh, Sebastian R. van der Voort, Fatih Incekara, Arnaud Vincent, Martin Van den Bent, Johan M. Kros, Marion Smits, Esther A.H. Warnert^*

^*Corresponding author for this work

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Abstract

In this study, we used the vessel size imaging (VSI) MRI technique to characterize the microvasculature features of three subtypes of adult-type diffuse glioma lacking enhancement. Thirty-eight patients with confirmed non-enhancing glioma were categorized into three subtypes: Oligo (IDH-mut&1p/19q-codeleted), Astro (IDH-mut), and GBM (IDH-wt). The VSI technique provided quantitative maps of cerebral blood volume (CBV), microvasculature (µCBV), and vessel size for each patient. Additionally, tissue samples of 21 patients were histopathologically analyzed, and microvasculature features were quantified. Both MRI- and histology-derived features were compared across the three glioma subtypes with ANOVA or Kruskal–Wallis tests. Group averages of CBV, μCBV, and vessel size were significantly different between the three glioma subtypes (p < 0.01). Astro (IDH-mut) had a significantly lower CBV and µCBV compared to Oligo (IDH-mut&1p/19q-codeleted) (p = 0.004 and p = 0.001, respectively), and a higher average vessel size compared to GBM (IDH-wt) (p = 0.01). The histopathological analysis showed that GBM (IDH-wt) possessed vessels with more irregular shapes than the two other subtypes (p < 0.05). VSI provides a good insight into the microvasculature characteristics of the three adult-type glioma subtypes even when lacking enhancement. Further investigations into the specificity of VSI to differentiate glioma subtypes are thus warranted.

Original language	English
Article number	2135
Journal	Cancers
Volume	15
Issue number	7
DOIs	https://doi.org/10.3390/cancers15072135
Publication status	Published - 4 Apr 2023

Bibliographical note

Funding Information:
This research was funded by the Dutch Cancer Society (KWF): “Non-invasive phenotyping of molecular brain tumor profiles using novel advanced MR imaging and analysis”, EMCR 2015–7859. E.A.H.W. was funded by a “Veni Vernieuwingsimpuls” from the Dutch Research Council entitled “Food for thought: Oxygen delivery to the brain”, grant number 91619121. S.R.v.d.V. was funded by the Dutch Research Council open technology program, grant number 17079.

Publisher Copyright:
© 2023 by the authors.

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@article{417b10cc34ba4de8ba5900319011899f,

title = "Microvasculature Features Derived from Hybrid EPI MRI in Non-Enhancing Adult-Type Diffuse Glioma Subtypes",

abstract = "In this study, we used the vessel size imaging (VSI) MRI technique to characterize the microvasculature features of three subtypes of adult-type diffuse glioma lacking enhancement. Thirty-eight patients with confirmed non-enhancing glioma were categorized into three subtypes: Oligo (IDH-mut&1p/19q-codeleted), Astro (IDH-mut), and GBM (IDH-wt). The VSI technique provided quantitative maps of cerebral blood volume (CBV), microvasculature (µCBV), and vessel size for each patient. Additionally, tissue samples of 21 patients were histopathologically analyzed, and microvasculature features were quantified. Both MRI- and histology-derived features were compared across the three glioma subtypes with ANOVA or Kruskal–Wallis tests. Group averages of CBV, μCBV, and vessel size were significantly different between the three glioma subtypes (p < 0.01). Astro (IDH-mut) had a significantly lower CBV and µCBV compared to Oligo (IDH-mut&1p/19q-codeleted) (p = 0.004 and p = 0.001, respectively), and a higher average vessel size compared to GBM (IDH-wt) (p = 0.01). The histopathological analysis showed that GBM (IDH-wt) possessed vessels with more irregular shapes than the two other subtypes (p < 0.05). VSI provides a good insight into the microvasculature characteristics of the three adult-type glioma subtypes even when lacking enhancement. Further investigations into the specificity of VSI to differentiate glioma subtypes are thus warranted.",

author = "Fatemeh Arzanforoosh and {van der Voort}, {Sebastian R.} and Fatih Incekara and Arnaud Vincent and {Van den Bent}, Martin and Kros, {Johan M.} and Marion Smits and Warnert, {Esther A.H.}",

note = "Funding Information: This research was funded by the Dutch Cancer Society (KWF): “Non-invasive phenotyping of molecular brain tumor profiles using novel advanced MR imaging and analysis”, EMCR 2015–7859. E.A.H.W. was funded by a “Veni Vernieuwingsimpuls” from the Dutch Research Council entitled “Food for thought: Oxygen delivery to the brain”, grant number 91619121. S.R.v.d.V. was funded by the Dutch Research Council open technology program, grant number 17079. Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

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day = "4",

doi = "10.3390/cancers15072135",

language = "English",

volume = "15",

journal = "Cancers",

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T1 - Microvasculature Features Derived from Hybrid EPI MRI in Non-Enhancing Adult-Type Diffuse Glioma Subtypes

AU - Arzanforoosh, Fatemeh

AU - van der Voort, Sebastian R.

AU - Incekara, Fatih

AU - Vincent, Arnaud

AU - Van den Bent, Martin

AU - Kros, Johan M.

AU - Smits, Marion

AU - Warnert, Esther A.H.

N1 - Funding Information: This research was funded by the Dutch Cancer Society (KWF): “Non-invasive phenotyping of molecular brain tumor profiles using novel advanced MR imaging and analysis”, EMCR 2015–7859. E.A.H.W. was funded by a “Veni Vernieuwingsimpuls” from the Dutch Research Council entitled “Food for thought: Oxygen delivery to the brain”, grant number 91619121. S.R.v.d.V. was funded by the Dutch Research Council open technology program, grant number 17079. Publisher Copyright: © 2023 by the authors.

PY - 2023/4/4

Y1 - 2023/4/4

N2 - In this study, we used the vessel size imaging (VSI) MRI technique to characterize the microvasculature features of three subtypes of adult-type diffuse glioma lacking enhancement. Thirty-eight patients with confirmed non-enhancing glioma were categorized into three subtypes: Oligo (IDH-mut&1p/19q-codeleted), Astro (IDH-mut), and GBM (IDH-wt). The VSI technique provided quantitative maps of cerebral blood volume (CBV), microvasculature (µCBV), and vessel size for each patient. Additionally, tissue samples of 21 patients were histopathologically analyzed, and microvasculature features were quantified. Both MRI- and histology-derived features were compared across the three glioma subtypes with ANOVA or Kruskal–Wallis tests. Group averages of CBV, μCBV, and vessel size were significantly different between the three glioma subtypes (p < 0.01). Astro (IDH-mut) had a significantly lower CBV and µCBV compared to Oligo (IDH-mut&1p/19q-codeleted) (p = 0.004 and p = 0.001, respectively), and a higher average vessel size compared to GBM (IDH-wt) (p = 0.01). The histopathological analysis showed that GBM (IDH-wt) possessed vessels with more irregular shapes than the two other subtypes (p < 0.05). VSI provides a good insight into the microvasculature characteristics of the three adult-type glioma subtypes even when lacking enhancement. Further investigations into the specificity of VSI to differentiate glioma subtypes are thus warranted.

AB - In this study, we used the vessel size imaging (VSI) MRI technique to characterize the microvasculature features of three subtypes of adult-type diffuse glioma lacking enhancement. Thirty-eight patients with confirmed non-enhancing glioma were categorized into three subtypes: Oligo (IDH-mut&1p/19q-codeleted), Astro (IDH-mut), and GBM (IDH-wt). The VSI technique provided quantitative maps of cerebral blood volume (CBV), microvasculature (µCBV), and vessel size for each patient. Additionally, tissue samples of 21 patients were histopathologically analyzed, and microvasculature features were quantified. Both MRI- and histology-derived features were compared across the three glioma subtypes with ANOVA or Kruskal–Wallis tests. Group averages of CBV, μCBV, and vessel size were significantly different between the three glioma subtypes (p < 0.01). Astro (IDH-mut) had a significantly lower CBV and µCBV compared to Oligo (IDH-mut&1p/19q-codeleted) (p = 0.004 and p = 0.001, respectively), and a higher average vessel size compared to GBM (IDH-wt) (p = 0.01). The histopathological analysis showed that GBM (IDH-wt) possessed vessels with more irregular shapes than the two other subtypes (p < 0.05). VSI provides a good insight into the microvasculature characteristics of the three adult-type glioma subtypes even when lacking enhancement. Further investigations into the specificity of VSI to differentiate glioma subtypes are thus warranted.

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DO - 10.3390/cancers15072135

M3 - Article

C2 - 37046796

AN - SCOPUS:85152557833

SN - 2072-6694

VL - 15

JO - Cancers

JF - Cancers

IS - 7

M1 - 2135

ER -

Microvasculature Features Derived from Hybrid EPI MRI in Non-Enhancing Adult-Type Diffuse Glioma Subtypes

Abstract

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