Migraine and the risk of stroke in a middle-aged and elderly population: A prospective cohort study

Research output: Contribution to journalArticleAcademicpeer-review

2 Downloads (Pure)

Abstract

BACKGROUND: It has been suggested that patients with migraine have a higher risk of stroke. Despite considerable research on this topic in younger populations, a clear answer is still lacking for older individuals. We studied the association between migraine and the risk of stroke in a middle-aged and elderly population. METHODS: Within the ongoing prospective population-based Rotterdam Study, the presence of migraine was assessed using a validated questionnaire in a structured interview between 2006 and 2011, which formed the baseline. The association between migraine and the risk of stroke was analyzed using Cox proportional-hazards models with adjustments for age, sex, and cardiometabolic risk factors. RESULTS: A total of 6925 (mean age 65.7 ± 11.3 years, 57.8% females) stroke-free participants were included. At baseline, 1030 (14.9%) participants had lifetime history of migraine. During a median follow-up of 6.2 years, 195 participants developed a stroke (163 ischemic stroke). Analyzing the association between migraine and stroke, we found a hazard ratio of 1.44 with a 95% confidence interval of 0.96-2.15. The results were similar for the ischemic stroke (HR 1.50, CI: 0.97-2.32). CONCLUSION: Our data suggested an association between migraine and the risk of stroke in a middle-aged and elderly population, but this was not statistically significant.

Original languageEnglish
Article number3331024221132008
JournalCephalalgia : an international journal of headache
Volume43
Issue number1
DOIs
Publication statusPublished - 9 Jan 2023

Bibliographical note

Funding:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this
article: The Rotterdam Study is funded by Erasmus Medical
Center and Erasmus University, Rotterdam, Netherlands
Organization for the Health Research and Development
(ZonMw), the Research Institute for Diseases in the Elderly
(RIDE), the Ministry of Education, Culture and Science, the
Ministry for Health, Welfare and Sports, the European
Commission (DG XII), and the Municipality of Rotterdam.

Fingerprint

Dive into the research topics of 'Migraine and the risk of stroke in a middle-aged and elderly population: A prospective cohort study'. Together they form a unique fingerprint.

Cite this