Minimal residual disease (MRD) detection in acute lymphoblastic leukaemia based on fusion genes and genomic deletions: towards MRD for all

Roland P. Kuiper, Patricia G. Hoogeveen, Reno Bladergroen, Freerk van Dijk, Edwin Sonneveld, Frank N. van Leeuwen, Judith Boer, Irina Sergeeva, Harma Feitsma, Monique L. den Boer, Vincent H.J. van der Velden*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
29 Downloads (Pure)

Abstract

Minimal residual disease (MRD) diagnostics are implemented in most clinical protocols for patients with acute lymphoblastic leukaemia (ALL) and are mostly performed using rearranged immunoglobulin (IG) and/or T-cell receptor (TR) gene rearrangements as molecular polymerase chain reaction targets. Unfortunately, in 5–10% of patients no or no sensitive IG/TR targets are available, and patients therefore cannot be stratified appropriately. In the present study, we used fusion genes and genomic deletions as alternative MRD targets in these patients, which retrospectively revealed appropriate MDR stratification in 79% of patients with no (sensitive) IG/TR target, and a different risk group stratification in more than half of the cases.

Original languageEnglish
Pages (from-to)888-892
Number of pages5
JournalBritish Journal of Haematology
Volume194
Issue number5
DOIs
Publication statusPublished - 1 Sept 2021

Bibliographical note

Funding Information:
We gratefully acknowledge the support and contribution of Željko Antić, Simon V. van Reijmersdal, Lionel Morgado, Alex Hoogkamer, Marjolein Bakker, and Hester de Groot. We thank Erik Splinter, Petra Klous, and Max van Min for supporting the TLA analyses. This project was supported by KIKA (grant 308).

Funding Information:
We gratefully acknowledge the support and contribution of ?eljko Anti?, Simon V. van Reijmersdal, Lionel Morgado, Alex Hoogkamer, Marjolein Bakker, and Hester de Groot. We thank Erik Splinter, Petra Klous, and Max van Min for supporting the TLA analyses. This project was supported by KIKA (grant 308).

Publisher Copyright:
© 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd

Research programs

  • EMC MM-02-54-03

Fingerprint

Dive into the research topics of 'Minimal residual disease (MRD) detection in acute lymphoblastic leukaemia based on fusion genes and genomic deletions: towards MRD for all'. Together they form a unique fingerprint.

Cite this