Model of antral follicle dynamics during the 5-day cycle in rats based on measurement of antral follicle inflow

W. A. Van Cappellen*, P. Osman, H. M.A. Meijs-Roelofs

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Antral follicles were counted in ovaries from young adult Wistar rats, collected on the 5 days of the ovarian cycle. Follicles were classified as healthy, early atretic or late atretic and divided into five volume classes. From these data, a model was developed in which the inflow of healthy follicles into the various size classes was quantified. This model describes the follicle dynamics during a normal 5-day cycle. It was concluded that the stage of early atresia takes between 20 and 24 h. The inflow of follicles into the antral stage (volume ≥ 100 x 105 μm3) was continuous but not constant. The highest inflow was found during pro-oestrus and oestrus, at about the time of the first and second FSH surge. The total inflow during each cycle was about 120 follicles of which only 10% ovulated. These ovulating follicles were recruited during the previous pro-oestrus and oestrus. Follicle selection took place in volume classes I and ≥ (volume 100-350 x 105 μm3) during oestrus and dioestrus 1. At dioestrus 2, the follicles that will ovulate have been selected and can be recognized on the basis of their bigger size.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalJournal of Reproduction and Fertility
Volume99
Issue number1
DOIs
Publication statusPublished - 1993

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