Modelling the Interplay Between Chronic Stress and Type 2 Diabetes On-Set

Roland V. Bumbuc, Vehpi Yildirim, M. Vivek Sheraton*

*Corresponding author for this work

Research output: Contribution to conferencePaperAcademic

2 Citations (Scopus)

Abstract

Stress has become part of the day-to-day life in the modern world. A major pathological repercussion of chronic stress (CS) is Type 2 Diabetes (T2D). Modelling T2D as a complex biological system involves combining under-the-skin and outside-the-skin parameters to properly define the dynamics involved. In this study, a compartmental model is built based on the various inter-players that constitute the hallmarks involved in the progression of this disease. Various compartments that constitute this model are tested in a glucose-disease progression setting with the help of an adjacent minimal model. Temporal dynamics of the glucose-disease progression was simulated to explore the contribution of different model parameters to T2D onset. The model simulations reveal CS as a critical modulator of T2D disease progression.

Original languageEnglish
Pages330-338
Number of pages9
DOIs
Publication statusE-pub ahead of print - 26 Jun 2023
Externally publishedYes
Event23rd International Conference on Computational Science, ICCS 2023 - Prague, Czech Republic
Duration: 3 Jul 20235 Jul 2023

Conference

Conference23rd International Conference on Computational Science, ICCS 2023
Country/TerritoryCzech Republic
CityPrague
Period3/07/235/07/23

Bibliographical note

Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

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