Modulating the heat stress response to improve hyperthermia-based anticancer treatments

Enzo M. Scutigliani; Yongxin Liang; Hans Crezee; Roland Kanaar; Przemek M. Krawczyk

doi:10.3390/cancers13061243

Modulating the heat stress response to improve hyperthermia-based anticancer treatments

Enzo M. Scutigliani^*, Yongxin Liang, Hans Crezee, Roland Kanaar, Przemek M. Krawczyk

^*Corresponding author for this work

Molecular Genetics

Research output: Contribution to journal › Review article › Academic › peer-review

12 Citations (Scopus)

6 Downloads (Pure)

Abstract

Cancer treatments based on mild hyperthermia (39–43^◦C, HT) are applied to a widening range of cancer types, but several factors limit their efficacy and slow down more widespread adoption. These factors include difficulties in adequate heat delivery, a short therapeutic window and the acquisition of thermotolerance by cancer cells. Here, we explore the biological effects of HT, the cellular responses to these effects and their clinically-relevant consequences. We then identify the heat stress response—the cellular defense mechanism that detects and counteracts the effects of heat—as one of the major forces limiting the efficacy of HT-based therapies and propose targeting this mechanism as a potentially universal strategy for improving their efficacy.

Original language	English
Article number	1243
Pages (from-to)	1-20
Number of pages	20
Journal	Cancers
Volume	13
Issue number	6
DOIs	https://doi.org/10.3390/cancers13061243
Publication status	Published - 2 Mar 2021

Bibliographical note

Funding Information:
This research was funded by the Dutch Cancer Society (grant number 11143). PMK and HC are members of the H2020 European Training Network ?HYPERBOOST: Hyperthermia boosting the effect of Radiotherapy? (grant number 955625). This work was also supported by the Gravitation program CancerGenomiCs.nl from the Netherlands Organisation for Scientific Research (NWO), which is part of the Oncode Institute. The Oncode Institute is partly financed by the Dutch Cancer Society.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/cancers13061243Licence: CC BY

Modulating the Heat Stress Response to Improve Hyperthermia-Based Anticancer TreatmentsFinal published version, 1.21 MBLicence: CC BY

Cite this

@article{5086072ace8247219b5cadf450cd753b,

title = "Modulating the heat stress response to improve hyperthermia-based anticancer treatments",

abstract = "Cancer treatments based on mild hyperthermia (39–43◦C, HT) are applied to a widening range of cancer types, but several factors limit their efficacy and slow down more widespread adoption. These factors include difficulties in adequate heat delivery, a short therapeutic window and the acquisition of thermotolerance by cancer cells. Here, we explore the biological effects of HT, the cellular responses to these effects and their clinically-relevant consequences. We then identify the heat stress response—the cellular defense mechanism that detects and counteracts the effects of heat—as one of the major forces limiting the efficacy of HT-based therapies and propose targeting this mechanism as a potentially universal strategy for improving their efficacy.",

author = "Scutigliani, {Enzo M.} and Yongxin Liang and Hans Crezee and Roland Kanaar and Krawczyk, {Przemek M.}",

note = "Funding Information: This research was funded by the Dutch Cancer Society (grant number 11143). PMK and HC are members of the H2020 European Training Network ?HYPERBOOST: Hyperthermia boosting the effect of Radiotherapy? (grant number 955625). This work was also supported by the Gravitation program CancerGenomiCs.nl from the Netherlands Organisation for Scientific Research (NWO), which is part of the Oncode Institute. The Oncode Institute is partly financed by the Dutch Cancer Society. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = mar,

day = "2",

doi = "10.3390/cancers13061243",

language = "English",

volume = "13",

pages = "1--20",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "6",

}

TY - JOUR

T1 - Modulating the heat stress response to improve hyperthermia-based anticancer treatments

AU - Scutigliani, Enzo M.

AU - Liang, Yongxin

AU - Crezee, Hans

AU - Kanaar, Roland

AU - Krawczyk, Przemek M.

N1 - Funding Information: This research was funded by the Dutch Cancer Society (grant number 11143). PMK and HC are members of the H2020 European Training Network ?HYPERBOOST: Hyperthermia boosting the effect of Radiotherapy? (grant number 955625). This work was also supported by the Gravitation program CancerGenomiCs.nl from the Netherlands Organisation for Scientific Research (NWO), which is part of the Oncode Institute. The Oncode Institute is partly financed by the Dutch Cancer Society. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/3/2

Y1 - 2021/3/2

N2 - Cancer treatments based on mild hyperthermia (39–43◦C, HT) are applied to a widening range of cancer types, but several factors limit their efficacy and slow down more widespread adoption. These factors include difficulties in adequate heat delivery, a short therapeutic window and the acquisition of thermotolerance by cancer cells. Here, we explore the biological effects of HT, the cellular responses to these effects and their clinically-relevant consequences. We then identify the heat stress response—the cellular defense mechanism that detects and counteracts the effects of heat—as one of the major forces limiting the efficacy of HT-based therapies and propose targeting this mechanism as a potentially universal strategy for improving their efficacy.

AB - Cancer treatments based on mild hyperthermia (39–43◦C, HT) are applied to a widening range of cancer types, but several factors limit their efficacy and slow down more widespread adoption. These factors include difficulties in adequate heat delivery, a short therapeutic window and the acquisition of thermotolerance by cancer cells. Here, we explore the biological effects of HT, the cellular responses to these effects and their clinically-relevant consequences. We then identify the heat stress response—the cellular defense mechanism that detects and counteracts the effects of heat—as one of the major forces limiting the efficacy of HT-based therapies and propose targeting this mechanism as a potentially universal strategy for improving their efficacy.

UR - http://www.scopus.com/inward/record.url?scp=85102376653&partnerID=8YFLogxK

U2 - 10.3390/cancers13061243

DO - 10.3390/cancers13061243

M3 - Review article

AN - SCOPUS:85102376653

SN - 2072-6694

VL - 13

SP - 1

EP - 20

JO - Cancers

JF - Cancers

IS - 6

M1 - 1243

ER -

Modulating the heat stress response to improve hyperthermia-based anticancer treatments

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this