Modulating the heat stress response to improve hyperthermia-based anticancer treatments

Enzo M. Scutigliani*, Yongxin Liang, Hans Crezee, Roland Kanaar, Przemek M. Krawczyk

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

7 Citations (Scopus)


Cancer treatments based on mild hyperthermia (39–43C, HT) are applied to a widening range of cancer types, but several factors limit their efficacy and slow down more widespread adoption. These factors include difficulties in adequate heat delivery, a short therapeutic window and the acquisition of thermotolerance by cancer cells. Here, we explore the biological effects of HT, the cellular responses to these effects and their clinically-relevant consequences. We then identify the heat stress response—the cellular defense mechanism that detects and counteracts the effects of heat—as one of the major forces limiting the efficacy of HT-based therapies and propose targeting this mechanism as a potentially universal strategy for improving their efficacy.

Original languageEnglish
Article number1243
Pages (from-to)1-20
Number of pages20
Issue number6
Publication statusPublished - 2 Mar 2021


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