Modulation of control: Can HD-tDCS targeting the dACC reduce impulsivity?

Ilse Verveer; Aron T. Hill; Ingmar H.A. Franken; Murat Yücel; Josanne D.M. van Dongen; Rebecca Segrave

doi:10.1016/j.brainres.2021.147282

Modulation of control: Can HD-tDCS targeting the dACC reduce impulsivity?

Ilse Verveer^*, Aron T. Hill, Ingmar H.A. Franken, Murat Yücel, Josanne D.M. van Dongen, Rebecca Segrave

^*Corresponding author for this work

Clinical Psychology

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

Background: The dorsal anterior cingulate cortex (dACC) and its neurocircuits are central in impulsivity, and maladaptive dACC activity has been implicated in psychological disorders characterized by high trait impulsivity. High-Definition transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive neuromodulation tool that, with certain electrode configurations, can be optimized for targeting deeper subcortical brain structures, such as the dACC. Objectives: Using behavioural and electrophysiological measures we investigated whether HD-tDCS targeting the dACC could modulate two key components of impulsivity, inhibitory control and error processing. Methods: Twenty-three healthy adults with high trait impulsivity participated in two experimental sessions. Participants received active or sham HD-tDCS in counterbalanced order with a wash-out period of at least 3 days, as part of a single-blind, cross-over design. EEG was recorded during the Go-NoGo task before, directly after, and 30 min after HD-tDCS. Results: HD-tDCS targeting the dACC did not affect inhibitory control performance on the Go-NoGo task, but there was evidence for a delayed change in underlying neurophysiological components of motor inhibition (NoGo P3) and error processing (error related negativity; ERN) after one session of HD-tDCS. Conclusion: HD-tDCS has potential to modulate underlying neurophysiological components of impulsivity. Future studies should further explore to what degree the dACC was affected and whether multi-session HD-tDCS has the capacity to also induce behavioural changes, particularly in clinical samples characterized by high trait impulsivity.

Original language	English
Article number	147282
Journal	Brain Research
Volume	1756
DOIs	https://doi.org/10.1016/j.brainres.2021.147282
Publication status	Published - 1 Apr 2021

Bibliographical note

Funding Information:
This work was supported by travel funding from ZonMw Translational Research (grant number: 446001013), ?Erasmus Trustfonds? from Erasmus University Rotterdam, and from ?Stichting Volksbond Rotterdam?. We are grateful to Dr. Alireza Shahbabaie for his contribution to the data collection. Murat Yucel has received funding from Monash University, and Australian Government funding bodies such as the National Health and Medical Research Council (NHMRC; including Fellowship #APP1117188), the Australian Research Council (ARC), Australian Defence Science and Technology (DST), and the Department of Industry, Innovation and Science (DIIS). He has also received philanthropic donations from the David Winston Turner Endowment Fund, Wilson Foundation, as well as payment from law firms in relation to court, expert witness, and/or expert review reports. Rebecca Segrave received funding from Monash University and the David Winston Turner Endowment Fund. The funding sources had no role in the design, management, data analysis, presentation, or interpretation and write-up of the data.

Funding Information:
This work was supported by travel funding from ZonMw Translational Research (grant number: 446001013), ‘Erasmus Trustfonds’ from Erasmus University Rotterdam, and from ‘Stichting Volksbond Rotterdam’. We are grateful to Dr. Alireza Shahbabaie for his contribution to the data collection. Murat Yucel has received funding from Monash University, and Australian Government funding bodies such as the National Health and Medical Research Council (NHMRC; including Fellowship #APP1117188), the Australian Research Council (ARC), Australian Defence Science and Technology (DST), and the Department of Industry, Innovation and Science (DIIS). He has also received philanthropic donations from the David Winston Turner Endowment Fund, Wilson Foundation, as well as payment from law firms in relation to court, expert witness, and/or expert review reports. Rebecca Segrave received funding from Monash University and the David Winston Turner Endowment Fund. The funding sources had no role in the design, management, data analysis, presentation, or interpretation and write-up of the data.

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© 2021 The Authors

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title = "Modulation of control: Can HD-tDCS targeting the dACC reduce impulsivity?",

abstract = "Background: The dorsal anterior cingulate cortex (dACC) and its neurocircuits are central in impulsivity, and maladaptive dACC activity has been implicated in psychological disorders characterized by high trait impulsivity. High-Definition transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive neuromodulation tool that, with certain electrode configurations, can be optimized for targeting deeper subcortical brain structures, such as the dACC. Objectives: Using behavioural and electrophysiological measures we investigated whether HD-tDCS targeting the dACC could modulate two key components of impulsivity, inhibitory control and error processing. Methods: Twenty-three healthy adults with high trait impulsivity participated in two experimental sessions. Participants received active or sham HD-tDCS in counterbalanced order with a wash-out period of at least 3 days, as part of a single-blind, cross-over design. EEG was recorded during the Go-NoGo task before, directly after, and 30 min after HD-tDCS. Results: HD-tDCS targeting the dACC did not affect inhibitory control performance on the Go-NoGo task, but there was evidence for a delayed change in underlying neurophysiological components of motor inhibition (NoGo P3) and error processing (error related negativity; ERN) after one session of HD-tDCS. Conclusion: HD-tDCS has potential to modulate underlying neurophysiological components of impulsivity. Future studies should further explore to what degree the dACC was affected and whether multi-session HD-tDCS has the capacity to also induce behavioural changes, particularly in clinical samples characterized by high trait impulsivity.",

author = "Ilse Verveer and Hill, {Aron T.} and Franken, {Ingmar H.A.} and Murat Y{\"u}cel and {van Dongen}, {Josanne D.M.} and Rebecca Segrave",

note = "Funding Information: This work was supported by travel funding from ZonMw Translational Research (grant number: 446001013), ?Erasmus Trustfonds? from Erasmus University Rotterdam, and from ?Stichting Volksbond Rotterdam?. We are grateful to Dr. Alireza Shahbabaie for his contribution to the data collection. Murat Yucel has received funding from Monash University, and Australian Government funding bodies such as the National Health and Medical Research Council (NHMRC; including Fellowship #APP1117188), the Australian Research Council (ARC), Australian Defence Science and Technology (DST), and the Department of Industry, Innovation and Science (DIIS). He has also received philanthropic donations from the David Winston Turner Endowment Fund, Wilson Foundation, as well as payment from law firms in relation to court, expert witness, and/or expert review reports. Rebecca Segrave received funding from Monash University and the David Winston Turner Endowment Fund. The funding sources had no role in the design, management, data analysis, presentation, or interpretation and write-up of the data. Funding Information: This work was supported by travel funding from ZonMw Translational Research (grant number: 446001013), {\textquoteleft}Erasmus Trustfonds{\textquoteright} from Erasmus University Rotterdam, and from {\textquoteleft}Stichting Volksbond Rotterdam{\textquoteright}. We are grateful to Dr. Alireza Shahbabaie for his contribution to the data collection. Murat Yucel has received funding from Monash University, and Australian Government funding bodies such as the National Health and Medical Research Council (NHMRC; including Fellowship #APP1117188), the Australian Research Council (ARC), Australian Defence Science and Technology (DST), and the Department of Industry, Innovation and Science (DIIS). He has also received philanthropic donations from the David Winston Turner Endowment Fund, Wilson Foundation, as well as payment from law firms in relation to court, expert witness, and/or expert review reports. Rebecca Segrave received funding from Monash University and the David Winston Turner Endowment Fund. The funding sources had no role in the design, management, data analysis, presentation, or interpretation and write-up of the data. Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = apr,

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doi = "10.1016/j.brainres.2021.147282",

language = "English",

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AU - Yücel, Murat

AU - van Dongen, Josanne D.M.

AU - Segrave, Rebecca

N1 - Funding Information: This work was supported by travel funding from ZonMw Translational Research (grant number: 446001013), ?Erasmus Trustfonds? from Erasmus University Rotterdam, and from ?Stichting Volksbond Rotterdam?. We are grateful to Dr. Alireza Shahbabaie for his contribution to the data collection. Murat Yucel has received funding from Monash University, and Australian Government funding bodies such as the National Health and Medical Research Council (NHMRC; including Fellowship #APP1117188), the Australian Research Council (ARC), Australian Defence Science and Technology (DST), and the Department of Industry, Innovation and Science (DIIS). He has also received philanthropic donations from the David Winston Turner Endowment Fund, Wilson Foundation, as well as payment from law firms in relation to court, expert witness, and/or expert review reports. Rebecca Segrave received funding from Monash University and the David Winston Turner Endowment Fund. The funding sources had no role in the design, management, data analysis, presentation, or interpretation and write-up of the data. Funding Information: This work was supported by travel funding from ZonMw Translational Research (grant number: 446001013), ‘Erasmus Trustfonds’ from Erasmus University Rotterdam, and from ‘Stichting Volksbond Rotterdam’. We are grateful to Dr. Alireza Shahbabaie for his contribution to the data collection. Murat Yucel has received funding from Monash University, and Australian Government funding bodies such as the National Health and Medical Research Council (NHMRC; including Fellowship #APP1117188), the Australian Research Council (ARC), Australian Defence Science and Technology (DST), and the Department of Industry, Innovation and Science (DIIS). He has also received philanthropic donations from the David Winston Turner Endowment Fund, Wilson Foundation, as well as payment from law firms in relation to court, expert witness, and/or expert review reports. Rebecca Segrave received funding from Monash University and the David Winston Turner Endowment Fund. The funding sources had no role in the design, management, data analysis, presentation, or interpretation and write-up of the data. Publisher Copyright: © 2021 The Authors

PY - 2021/4/1

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N2 - Background: The dorsal anterior cingulate cortex (dACC) and its neurocircuits are central in impulsivity, and maladaptive dACC activity has been implicated in psychological disorders characterized by high trait impulsivity. High-Definition transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive neuromodulation tool that, with certain electrode configurations, can be optimized for targeting deeper subcortical brain structures, such as the dACC. Objectives: Using behavioural and electrophysiological measures we investigated whether HD-tDCS targeting the dACC could modulate two key components of impulsivity, inhibitory control and error processing. Methods: Twenty-three healthy adults with high trait impulsivity participated in two experimental sessions. Participants received active or sham HD-tDCS in counterbalanced order with a wash-out period of at least 3 days, as part of a single-blind, cross-over design. EEG was recorded during the Go-NoGo task before, directly after, and 30 min after HD-tDCS. Results: HD-tDCS targeting the dACC did not affect inhibitory control performance on the Go-NoGo task, but there was evidence for a delayed change in underlying neurophysiological components of motor inhibition (NoGo P3) and error processing (error related negativity; ERN) after one session of HD-tDCS. Conclusion: HD-tDCS has potential to modulate underlying neurophysiological components of impulsivity. Future studies should further explore to what degree the dACC was affected and whether multi-session HD-tDCS has the capacity to also induce behavioural changes, particularly in clinical samples characterized by high trait impulsivity.

AB - Background: The dorsal anterior cingulate cortex (dACC) and its neurocircuits are central in impulsivity, and maladaptive dACC activity has been implicated in psychological disorders characterized by high trait impulsivity. High-Definition transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive neuromodulation tool that, with certain electrode configurations, can be optimized for targeting deeper subcortical brain structures, such as the dACC. Objectives: Using behavioural and electrophysiological measures we investigated whether HD-tDCS targeting the dACC could modulate two key components of impulsivity, inhibitory control and error processing. Methods: Twenty-three healthy adults with high trait impulsivity participated in two experimental sessions. Participants received active or sham HD-tDCS in counterbalanced order with a wash-out period of at least 3 days, as part of a single-blind, cross-over design. EEG was recorded during the Go-NoGo task before, directly after, and 30 min after HD-tDCS. Results: HD-tDCS targeting the dACC did not affect inhibitory control performance on the Go-NoGo task, but there was evidence for a delayed change in underlying neurophysiological components of motor inhibition (NoGo P3) and error processing (error related negativity; ERN) after one session of HD-tDCS. Conclusion: HD-tDCS has potential to modulate underlying neurophysiological components of impulsivity. Future studies should further explore to what degree the dACC was affected and whether multi-session HD-tDCS has the capacity to also induce behavioural changes, particularly in clinical samples characterized by high trait impulsivity.

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Modulation of control: Can HD-tDCS targeting the dACC reduce impulsivity?

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