MODULATION OF DENDRITIC CELLS AND REGULATORY T CELLS BY NATURALLY OCCURRING ANTIBODIES

Jaap Kwekkeboom

Research output: Contribution to journalArticleAcademic

18 Citations (Scopus)

Abstract

Most studies on the effects of naturally occurring autoantibodies (NAbs) on immune cells have been performed in the context of research on the immunomodulatory effects of intravenous immunoglobulin (IVIG). Among others, IVIG inhibits the differentiation, maturation and functions of dendritic cells (DC), thereby suppressing T-cell activation. In addition, IVIG stimulates expansion and suppressive function of regulatory T cells (Treg) carrying the antigens CD4, CD25 and Foxp3. Current data on the immunomodulatory effects of IVIG on DC and Treg are summarized, and possible molecular interactions between NAbs and DC or Treg that mediate these effects are discussed.
Original languageUndefined/Unknown
Pages (from-to)133-144
Number of pages12
JournalAdvances in experimental medicine and biology
Volume750
Publication statusPublished - 2012

Research programs

  • EMC MM-04-20-01

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