TY - JOUR
T1 - Molecular classification of amyotrophic lateral sclerosis by unsupervised clustering of gene expression in motor cortex
AU - Aronica, Eleonora
AU - Baas, Frank
AU - Iyer, Anand
AU - ten Asbroek, Anneloor L.M.A.
AU - Morello, Giovanna
AU - Cavallaro, Sebastiano
N1 - Publisher Copyright: © 2014.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. Although 10% of ALS cases are familial (FALS), the majority are sporadic (SALS) and probably associated to a multifactorial etiology. Currently there is no cure or prevention for ALS. A prerequisite to formulating therapeutic strategies is gaining understanding of its etio-pathogenic mechanisms. In this study we analyzed whole-genome expression profiles of 41 motor cortex samples of control (10) and sporadic ALS (31) patients. Unsupervised hierarchical clustering was able to separate control from SALS patients. In addition, SALS patients were subdivided in two different groups that were associated to different deregulated pathways and genes, some of which were previously associated to familiar ALS. These experiments are the first to highlight the genomic heterogeneity of sporadic ALS and reveal new clues to its pathogenesis and potential therapeutic targets.
AB - Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and ultimately fatal neurodegenerative disease, caused by the loss of motor neurons in the brain and spinal cord. Although 10% of ALS cases are familial (FALS), the majority are sporadic (SALS) and probably associated to a multifactorial etiology. Currently there is no cure or prevention for ALS. A prerequisite to formulating therapeutic strategies is gaining understanding of its etio-pathogenic mechanisms. In this study we analyzed whole-genome expression profiles of 41 motor cortex samples of control (10) and sporadic ALS (31) patients. Unsupervised hierarchical clustering was able to separate control from SALS patients. In addition, SALS patients were subdivided in two different groups that were associated to different deregulated pathways and genes, some of which were previously associated to familiar ALS. These experiments are the first to highlight the genomic heterogeneity of sporadic ALS and reveal new clues to its pathogenesis and potential therapeutic targets.
UR - http://www.scopus.com/inward/record.url?scp=84922684099&partnerID=8YFLogxK
U2 - 10.1016/j.nbd.2014.12.002
DO - 10.1016/j.nbd.2014.12.002
M3 - Article
C2 - 25500340
AN - SCOPUS:84922684099
SN - 0969-9961
VL - 74
SP - 359
EP - 376
JO - Neurobiology of Disease
JF - Neurobiology of Disease
ER -