Molecular epidemiology and brief history of emerging adenovirus 14-associated respiratory disease in the United States

Adriana E. Kajon*, Xiaoyan Lu, Dean D. Erdman, Janice Louie, David Schnurr, Kirsten St. George, Marion P. Koopmans, Taslim Allibhai, David Metzgar

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

110 Citations (Scopus)
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Abstract

Background. First isolated in the Netherlands in 1955 during an outbreak of acute respiratory disease (ARD) among military recruits, human adenovirus 14 (HAdV-14) has historically been considered rare. With no precedent of circulation in North America, HAdV-14 has been isolated from military and civilian cases of ARD of variable severity since 2003 in the United States. Methods. Ninety-nine isolates from military and civilian cases from different geographic locations and circulation periods were characterized by restriction enzyme analysis of viral DNA and select gene sequencing. Results. All examined viruses were found to be identical and to belong to a new genome type designated "HAdV-14p1" (formerly known as "14a"). Comparative alignments of E1A, hexon, and fiber gene sequences with other subspecies B2 HAdVs suggest that HAdV-14p1, like the closely related HAdV-11a, arose from recombination among similar HAdV-11 and HAdV-14 ancestral strains. A deletion of 2 amino acids in the knob region of the fiber protein is the only identified unique characteristic of HAdV-14p1. Conclusion. The current geographic distribution of HAdV-14p1 involves at least 15 states in the Unites States. The role of the fiber mutations in the recent emergence of HAdV-14p1 ARD in North America warrants further study.

Original languageEnglish
Pages (from-to)93-103
Number of pages11
JournalJournal of Infectious Diseases
Volume202
Issue number1
DOIs
Publication statusPublished - 1 Jul 2010
Externally publishedYes

Bibliographical note

Funding Information:
Financial support: This work represents Naval Health Research Center report no. 09–17, supported by the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center, and the Henry M. Jackson Foundation for the Advancement of Military Medicine under research work unit 60805.

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