TY - JOUR
T1 - Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands
AU - Roest, Hendrik I J
AU - Ruuls, Robin C
AU - Tilburg, Jeroen J H C
AU - Nabuurs-Franssen, Marrigje H
AU - Klaassen, Corne H W
AU - Vellema, Piet
AU - van den Brom, René
AU - Dercksen, Daan
AU - Wouda, Willem
AU - Spierenburg, Marcel A H
AU - van der Spek, Arco N
AU - Buijs, Rob
AU - de Boer, Albert G
AU - Willemsen, Peter Th J
AU - van Zijderveld, Fred G
PY - 2011/4
Y1 - 2011/4
N2 - Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of the largest reported outbreaks of Q fever in humans occurred in the Netherlands starting in 2007; epidemiologic investigations identified small ruminants as the source. To determine the genetic background of C. burnetii in domestic ruminants responsible for the human Q fever outbreak, we genotyped 126 C. burnetii-positive samples from ruminants by using a 10-loci multilocus variable-number tandem-repeat analyses panel and compared them with internationally known genotypes. One unique genotype predominated in dairy goat herds and 1 sheep herd in the human Q fever outbreak area in the south of the Netherlands. On the basis of 4 loci, this genotype is similar to a human genotype from the Netherlands. This finding strengthens the probability that this genotype of C. burnetii is responsible for the human Q fever epidemic in the Netherlands.
AB - Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of the largest reported outbreaks of Q fever in humans occurred in the Netherlands starting in 2007; epidemiologic investigations identified small ruminants as the source. To determine the genetic background of C. burnetii in domestic ruminants responsible for the human Q fever outbreak, we genotyped 126 C. burnetii-positive samples from ruminants by using a 10-loci multilocus variable-number tandem-repeat analyses panel and compared them with internationally known genotypes. One unique genotype predominated in dairy goat herds and 1 sheep herd in the human Q fever outbreak area in the south of the Netherlands. On the basis of 4 loci, this genotype is similar to a human genotype from the Netherlands. This finding strengthens the probability that this genotype of C. burnetii is responsible for the human Q fever epidemic in the Netherlands.
U2 - 10.3201/eid1704.101562
DO - 10.3201/eid1704.101562
M3 - Article
C2 - 21470457
SN - 1080-6040
VL - 17
SP - 668
EP - 675
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 4
ER -