TY - JOUR
T1 - Molecular epidemiology of wild poliovirus type 1 in europe, the middle east, and the indian subcontinent
AU - Mulders, Mick N.
AU - Lipskaya, Galina Y.
AU - Van der Avoort, Harrie G.A.M.
AU - Koopmans, Marion P.G.
AU - Kew, Olen M.
AU - Van Loon, Anton M.
PY - 1995/6
Y1 - 1995/6
N2 - The genomic relationships of wild poliovirus type 1 strains recently isolated in Europe, the Middle East, and the Indian subcontinent was analyzed by automated amplicon sequencing of the VPl/2A junction region of the genome. Four major genotypes of poliovirus type 1 were found to circulate. Two genotypes were found predominantly in Eastern Europe, one of these in the Caucasian Region and the other in countries bordering the Black Sea. A third genotype circulated mainly in Egypt. The fourth and largest genotype circulated in the largest geographic area. Strains belonging to this genotype could be found in countries as far apart as Malaysia and Ukraine. Considerable genetic variation was observed among strains isolated in Egypt, Pakistan, and India, where poliovirus is endemic. Strains belonging to all four genotypes circulated in Pakistan. Data confirm the extent of poliovirus circulation in certain regions, stressing the need for intensification of vaccination in these regions.
AB - The genomic relationships of wild poliovirus type 1 strains recently isolated in Europe, the Middle East, and the Indian subcontinent was analyzed by automated amplicon sequencing of the VPl/2A junction region of the genome. Four major genotypes of poliovirus type 1 were found to circulate. Two genotypes were found predominantly in Eastern Europe, one of these in the Caucasian Region and the other in countries bordering the Black Sea. A third genotype circulated mainly in Egypt. The fourth and largest genotype circulated in the largest geographic area. Strains belonging to this genotype could be found in countries as far apart as Malaysia and Ukraine. Considerable genetic variation was observed among strains isolated in Egypt, Pakistan, and India, where poliovirus is endemic. Strains belonging to all four genotypes circulated in Pakistan. Data confirm the extent of poliovirus circulation in certain regions, stressing the need for intensification of vaccination in these regions.
UR - http://www.scopus.com/inward/record.url?scp=0029000122&partnerID=8YFLogxK
U2 - 10.1093/infdis/171.6.1399
DO - 10.1093/infdis/171.6.1399
M3 - Article
C2 - 7769273
AN - SCOPUS:0029000122
SN - 0022-1899
VL - 171
SP - 1399
EP - 1405
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -
