Molecular imaging of inflammation and intraplaque vasa vasorum

Gerrit L. Ten Kate*, Stijn C.H. Van Den Oord, Eric J.G. Sijbrands, Antonius F.W. Van Der Steen, Arend F.L. Schinkel

*Corresponding author for this work

Research output: Chapter/Conference proceedingChapterAcademic

Abstract

Intraplaque neovascularization is a strong predictor of intraplaque hemorrhage and subsequent plaque rupture. Intraplaque neovascularization is caused by angiogenesis under the influence of hypoxic and inflammatory stimuli. All imaging modalities currently used in clinical practice are able to evaluate angiogenic activity by molecular imaging. However, translation to a clinical setting is limited. This chapter discusses the current status of molecular imaging to identify inflammation and intraplaque neovascularization, as a marker of plaque vulnerability.

Original languageEnglish
Title of host publicationMulti-Modality Atherosclerosis Imaging and Diagnosis
PublisherSpringer New York
Pages299-316
Number of pages18
Volume9781461474258
ISBN (Electronic)9781461474258
ISBN (Print)1461474248, 9781461474241
DOIs
Publication statusPublished - 1 Jul 2013

Bibliographical note

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© 2014 Springer Science+Business Media, LLC. All rights are reserved.

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