Monitoring trastuzumab-induced cardiotoxicity in her2-positive breast cancer

NI Bouwer

Monitoring trastuzumab-induced cardiotoxicity in her2-positive breast cancer

NI Bouwer

Erasmus MC other

Research output: Types of Thesis › Doctoral Thesis › Internal

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Abstract

This goal of this thesis was to contribute to the current body of evidence of anti-cancer therapy related cardiotoxicity, with particular focus on trastuzumab-induced cardiotoxicity during HER2-positive metastatic breast cancer (MBC). We found that serial cardiac monitoring is warranted in patients with HER2-positive MBC and certain risk factors. A novel imaging method is speckle tracking 2D-echocardiography (2DE-ST). In this thesis we found that GLS measurement with 2DE-ST could predict cardiotoxicity earlier and with greater accuracy. Further research is warranted on the role of NT-proBNP to identify cardiac dysfunction. Regarding the trastuzumab treatment, discontinuation after complete radiological remission should be carefully considered. In addition, a baseline LVEF

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	Boersma, Eric, Supervisor Levin, Mark-David, Co-supervisor Kofflard, MJM, Co-supervisor
Award date	21 Sept 2022
Place of Publication	Rotterdam
Print ISBNs	978-94-6458-432-5
Publication status	Published - 21 Sept 2022

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final dissertation Bouwer, NathalieFinal published version, 4.57 MBLicence: Unspecified
embargo version Bouwer, NathalieOther version, 5.47 MBLicence: Unspecified

Cite this

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title = "Monitoring trastuzumab-induced cardiotoxicity in her2-positive breast cancer",

abstract = "This goal of this thesis was to contribute to the current body of evidence of anti-cancer therapy related cardiotoxicity, with particular focus on trastuzumab-induced cardiotoxicity during HER2-positive metastatic breast cancer (MBC). We found that serial cardiac monitoring is warranted in patients with HER2-positive MBC and certain risk factors. A novel imaging method is speckle tracking 2D-echocardiography (2DE-ST). In this thesis we found that GLS measurement with 2DE-ST could predict cardiotoxicity earlier and with greater accuracy. Further research is warranted on the role of NT-proBNP to identify cardiac dysfunction. Regarding the trastuzumab treatment, discontinuation after complete radiological remission should be carefully considered. In addition, a baseline LVEF ",

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AU - Bouwer, NI

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N2 - This goal of this thesis was to contribute to the current body of evidence of anti-cancer therapy related cardiotoxicity, with particular focus on trastuzumab-induced cardiotoxicity during HER2-positive metastatic breast cancer (MBC). We found that serial cardiac monitoring is warranted in patients with HER2-positive MBC and certain risk factors. A novel imaging method is speckle tracking 2D-echocardiography (2DE-ST). In this thesis we found that GLS measurement with 2DE-ST could predict cardiotoxicity earlier and with greater accuracy. Further research is warranted on the role of NT-proBNP to identify cardiac dysfunction. Regarding the trastuzumab treatment, discontinuation after complete radiological remission should be carefully considered. In addition, a baseline LVEF

AB - This goal of this thesis was to contribute to the current body of evidence of anti-cancer therapy related cardiotoxicity, with particular focus on trastuzumab-induced cardiotoxicity during HER2-positive metastatic breast cancer (MBC). We found that serial cardiac monitoring is warranted in patients with HER2-positive MBC and certain risk factors. A novel imaging method is speckle tracking 2D-echocardiography (2DE-ST). In this thesis we found that GLS measurement with 2DE-ST could predict cardiotoxicity earlier and with greater accuracy. Further research is warranted on the role of NT-proBNP to identify cardiac dysfunction. Regarding the trastuzumab treatment, discontinuation after complete radiological remission should be carefully considered. In addition, a baseline LVEF

M3 - Doctoral Thesis

SN - 978-94-6458-432-5

CY - Rotterdam

ER -

Monitoring trastuzumab-induced cardiotoxicity in her2-positive breast cancer

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