MorphSet: Improving Renal Histopathology Case Assessment Through Learned Prognostic Vectors

Pietro Antonio Cicalese*, Syed Asad Rizvi, Victor Wang, Sai Patibandla, Pengyu Yuan, Samira Zare, Katharina Moos, Ibrahim Batal, Marian Clahsen-van Groningen, Candice Roufosse, Jan Becker, Chandra Mohan, Hien Van Nguyen

*Corresponding author for this work

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review

Abstract

Computer Aided Diagnosis (CAD) systems for renal histopathology applications aim to understand and replicate nephropathologists’ assessments of individual morphological compartments (e.g. glomeruli) to render case-level histological diagnoses. Deep neural networks (DNNs) hold great promise in addressing the poor intra- and interobserver agreement between pathologists. This being said, the generalization ability of DNNs heavily depends on the quality and quantity of training labels. Current “consensus” labeling strategies require multiple pathologists to evaluate every compartment unit over thousands of crops, resulting in enormous annotative costs. Additionally, these techniques fail to address the underlying reproducibility issues we observe across various diagnostic feature assessment tasks. To address both of these limitations, we introduce MorphSet, an end-to-end architecture inspired by Set Transformers which maps the combined encoded representations of Monte Carlo (MC) sampled glomerular compartment crops to produce Whole Slide Image (WSI) predictions on a case basis without the need for expensive fine-grained morphological feature labels. To evaluate performance, we use a kidney transplant Antibody Mediated Rejection (AMR) dataset, and show that we are able to achieve 98.9% case level accuracy, outperforming the consensus label baseline. Finally, we generate a visualization of prediction confidence derived from our MC evaluation experiments, which provides physicians with valuable feedback.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer Assisted Intervention – MICCAI 2021 - 24th International Conference, Proceedings
EditorsMarleen de Bruijne, Philippe C. Cattin, Stéphane Cotin, Nicolas Padoy, Stefanie Speidel, Yefeng Zheng, Caroline Essert
PublisherSpringer Science+Business Media
Pages319-328
Number of pages10
ISBN (Print)9783030872366
DOIs
Publication statusE-pub ahead of print - 21 Sep 2021
Event24th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2021 - Virtual, Online
Duration: 27 Sep 20211 Oct 2021

Publication series

SeriesLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12908 LNCS
ISSN0302-9743

Conference

Conference24th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2021
CityVirtual, Online
Period27/09/211/10/21

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