Mortality and Morbidity Reduction by Primary Percutaneous Coronary Intervention Is Independent of the Patient's Age

Sanneke Boer, CM Westerhout, RJ Simes, CB Granger, Felix Zijlstra, Eric Boersma

Research output: Contribution to journalArticleAcademic

38 Citations (Scopus)

Abstract

Objectives The aim of this study was to obtain a valid estimate of the clinical effects of primary percutaneous coronary intervention (PPCI) in relation to age. Background Treatment with PPCI is most beneficial in high-risk myocardial infarction patients. Paradoxically, elderly patients, who are at increased risk of adverse outcome, are often withheld PPCI. Methods Individual patient data were obtained from 22 randomized trials (n = 6,763) evaluating the clinical effects of PPCI versus fibrinolysis (FL). Differences in 30-day death, repeat myocardial infarction, and stroke between patients randomized to FL and PPCI were determined in 5 age-strata: <= 50, >50 to 60, >60 to 70, >70 to 80, and >80 years. Treatment effects are reported as odds ratios (ORs) and 95% confidence intervals (CI). Multivariable logistic regression analyses, which included age x treatment interaction, were applied to examine evidence of heterogeneity in age-specific ORs. Results Thirty-day death increased with increasing age and ranged from 1.1% (FL) and 1.8% (PPCI) in patients <= 50 years to 26.4% and 18.3% in patients >80 years of age. The point estimate of treatment effect (overall adjusted OR: 0.65; 95% Cl: 0.52 to 0.79) was compatible with a mortality reduction favoring PPCI in all age-strata (except in patients 50 years of age), and 95% CIs were largely overlapping. There was no evidence of heterogeneity in ORs between age categories. Similar results were observed for repeat myocardial infarction and stroke. Conclusions In this analysis of randomized trials, the reduction in clinical end points by PPCI was not influenced by age. Hence, age per se should not be considered an exclusion criterion for the application of PPCI. (J Am Coll Cardiol Intv 2010;3:324-31) (C) 2010 by the American College of Cardiology Foundation
Original languageUndefined/Unknown
Pages (from-to)324-331
Number of pages8
JournalJACC-Cardiovascular interventions
Volume3
Issue number3
DOIs
Publication statusPublished - 2010

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