Most Promising Approaches to Improve Brain AVM Management: ARISE i Consensus Recommendations

Edgar A. Samaniego*, Guilherme Dabus, Philip M. Meyers, Peter T. Kan, Juhana Frösen, Giuseppe Lanzino, Babu G. Welch, Victor Volovici, Fernando Gonzalez, Johana Fifi, Fady T. Charbel, Brian L. Hoh, Alexander Khalessi, Michael P. Marks, Alejandro Berenstein, Victor M. Pereira, Mark Bain, Geoffrey P. Colby, Sandra Narayanan, Satoshi TateshimaAdnan H. Siddiqui, Ajay K. Wakhloo, Adam S. Arthur, Michael T. Lawton

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Brain arteriovenous malformations (bAVMs) are complex, and rare arteriovenous shunts that present with a wide range of signs and symptoms, with intracerebral hemorrhage being the most severe. Despite prior societal position statements, there is no consensus on the management of these lesions. ARISE (Aneurysm/bAVM/cSDH Roundtable Discussion With Industry and Stroke Experts) was convened to discuss evidence-based approaches and enhance our understanding of these complex lesions. ARISE identified the need to develop scales to predict the risk of rupture of bAVMs, and the use of common data elements to perform prospective registries and clinical studies. Additionally, the group underscored the need for comprehensive patient management with specialized centers with expertise in cranial and spinal microsurgery, neurological endovascular surgery, and stereotactic radiosurgery. The collection of prospective multicenter data and gross specimens was deemed essential for improving bAVM characterization, genetic evaluation, and phenotyping. Finally, bAVMs should be managed within a multidisciplinary framework, with clinical studies and research conducted collaboratively across multiple centers, harnessing the collective expertise and centralization of resources.

Original languageEnglish
Pages (from-to)1449-1463
Number of pages15
Issue number5
Publication statusPublished - May 2024

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