Mouse models of kidney fibrosis

Rafael Kramann*, Sylvia Menzel

*Corresponding author for this work

Research output: Chapter/Conference proceedingChapterAcademic

4 Citations (Scopus)


Chronic kidney disease (CKD) affects over 10% of the worldwide population and kidney fibrosis is a main driver of CKD and considered a therapeutic target. The mechanisms leading to kidney fibrosis are highly complexed and can be best studied in rodent models. Here we describe the most commonly used kidney fibrosis models in mice, the unilateral ureteral obstruction (UUO) model and the ischemia reperfusion injury (IRI) model. Both models are easy to learn and can be applied in animals of different age, sex, and strain.

Original languageEnglish
Title of host publicationMyofibroblasts
Number of pages16
ISBN (Electronic)978-1-0716-1382-5
Publication statusPublished - 25 May 2021

Publication series

SeriesMethods in Molecular Biology

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2021.


Dive into the research topics of 'Mouse models of kidney fibrosis'. Together they form a unique fingerprint.

Cite this