Abstract
Chronic kidney disease (CKD) affects over 10% of the worldwide population and kidney fibrosis is a main driver of CKD and considered a therapeutic target. The mechanisms leading to kidney fibrosis are highly complexed and can be best studied in rodent models. Here we describe the most commonly used kidney fibrosis models in mice, the unilateral ureteral obstruction (UUO) model and the ischemia reperfusion injury (IRI) model. Both models are easy to learn and can be applied in animals of different age, sex, and strain.
Original language | English |
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Title of host publication | Myofibroblasts |
Pages | 323-338 |
Number of pages | 16 |
ISBN (Electronic) | 978-1-0716-1382-5 |
DOIs | |
Publication status | Published - 25 May 2021 |
Publication series
Series | Methods in Molecular Biology |
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ISSN | 1064-3745 |
Bibliographical note
Publisher Copyright:© Springer Science+Business Media, LLC, part of Springer Nature 2021.