Mouse models of kidney fibrosis

Rafael Kramann; Sylvia Menzel

doi:10.1007/978-1-0716-1382-5_22

Mouse models of kidney fibrosis

Rafael Kramann^*
, Sylvia Menzel

^*Corresponding author for this work

Internal Medicine

University Hospital RWTH Aachen

Research output: Chapter/Conference proceeding › Chapter › Academic

14 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) affects over 10% of the worldwide population and kidney fibrosis is a main driver of CKD and considered a therapeutic target. The mechanisms leading to kidney fibrosis are highly complexed and can be best studied in rodent models. Here we describe the most commonly used kidney fibrosis models in mice, the unilateral ureteral obstruction (UUO) model and the ischemia reperfusion injury (IRI) model. Both models are easy to learn and can be applied in animals of different age, sex, and strain.

Original language	English
Title of host publication	Myofibroblasts
Pages	323-338
Number of pages	16
ISBN (Electronic)	978-1-0716-1382-5
DOIs	https://doi.org/10.1007/978-1-0716-1382-5_22
Publication status	Published - 25 May 2021

Publication series

Series	Methods in Molecular Biology
ISSN	1064-3745

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2021.

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10.1007/978-1-0716-1382-5_22Licence: Unspecified

Cite this

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Mouse models of kidney fibrosis

Abstract

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