MR venography of the human brain using susceptibility weighted imaging at very high field strength

PJ Koopmans, Rashindra Manniesing, Wiro Niessen, MA Viergever, M Barth

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Objective We investigate the implications of high magnetic field strength on MR venography based on susceptibility-weighted imaging (SWI) and estimate the optimum echo time to obtain maximum contrast between blood and brain tissue. Materials and methods We measured tissue contrast and T*(2) relaxation times at 7 T of gray matter, white matter, and venous blood in vivo. Results T*(2) relaxation times of gray matter, white matter, and venous blood in vivo yielded 32.9 +/- 2.3, 27.7 +/- 4.3, and 7.4 +/- 1.4 ms, respectively. Optimum TE was found to be 15 ms which is supported by theoretical considerations. Using this optimum TE, we acquired 3D high resolution datasets with a large volume coverage in a short measurement time that show very detailed microanatomical structures of the human brain such as intracortical veins and laminar cortical substructures. Conclusions By applying optimised vessel filters (vesselness filter and vessel enhancing diffusion) whole brain MR venograms can be obtained at 7 T with a significantly reduced measurement time compared to 3 T.
Original languageUndefined/Unknown
Pages (from-to)149-158
Number of pages10
JournalMagnetic Resonance Materials in Physics Biology and Medicine
Issue number1-2
Publication statusPublished - 2008

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