MRSA surveillance programmes worldwide: moving towards a harmonised international approach

Valérie O. Baede, Michael Z. David, MRSA Surveillance Worldwide Study Group (ISAC), the ESCMID Study Group for Nosocomial Infections (ESGNI), the ESCMID Study Group for Staphylococci and Staphylococcal Diseases (ESGS), Arjana Tambic Andrasevic, Dominique S. Blanc, Michael Borg, Grainne Brennan, Boudewijn Catry, Aurélie Chabaud, Joanna Empel, Hege Enger, Marie Hallin, Marina Ivanova, Andreas Kronenberg, Kuntaman Kuntaman, Anders Rhod Larsen, Katrien Latour, Jodi A. Lindsay, Bruno Pichon, Dewi SantosaningsihLeo M. Schouls, François Vandenesch, Guido Werner, Dorota Żabicka, Helena Žemličková, Harald Seifert, Margreet C. Vos*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Multinational surveillance programmes for methicillin-resistant Staphylococcus aureus (MRSA) are dependent on national structures for data collection. This study aimed to capture the diversity of national MRSA surveillance programmes and to propose a framework for harmonisation of MRSA surveillance. The International Society of Antimicrobial Chemotherapy (ISAC) MRSA Working Group conducted a structured survey on MRSA surveillance programmes and organised a webinar to discuss the programmes’ strengths and challenges as well as guidelines for harmonisation. Completed surveys represented 24 MRSA surveillance programmes in 16 countries. Several countries reported separate epidemiological and microbiological surveillance. Informing clinicians and national policy-makers were the most common purposes of surveillance. Surveillance of bloodstream infections (BSIs) was present in all programmes. Other invasive infections were often included. Three countries reported active surveillance of MRSA carriage. Methodology and reporting of antimicrobial susceptibility, virulence factors, molecular genotyping and epidemiological metadata varied greatly. Current MRSA surveillance programmes rely upon heterogeneous data collection systems, which hampers international epidemiological monitoring and research. To harmonise MRSA surveillance, we suggest improving the integration of microbiological and epidemiological data, implementation of central biobanks for MRSA isolate collection, and inclusion of a representative sample of skin and soft-tissue infection cases in addition to all BSI cases.

Original languageEnglish
Article number106538
JournalInternational Journal of Antimicrobial Agents
Volume59
Issue number3
DOIs
Publication statusAccepted/In press - 26 Jan 2022

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