We present a compact multi-modal and multi-scale retinal imaging instrument with an angiographic functional extension for clinical use. The system integrates scanning laser ophthalmoscopy (SLO), optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities and provides multi-scale fields of view. For high resolution, and high lateral resolution in particular, cellular imaging correction of aberrations by adaptive optics (AO) is employed. The entire instrument has a compact design and the scanning head is mounted on motorized translation stages that enable 3D self-alignment with respect to the subject’s eye by tracking the pupil position. Retinal tracking, based on the information provided by SLO, is incorporated in the instrument to compensate for retinal motion during OCT imaging. The imaging capabilities of the multi-modal and multi-scale instrument were tested by imaging healthy volunteers and patients.
This work was supported by Horizon 2020, the European Union’s Framework Program for Research and Innovation under grant agreement no. 780989 (MERLIN). The funding organization had no role in the design or conduct of this research. JA, CV and PLA acknowledge financial support from the Spanish Ministry of Economy and Competitiveness through the “Severo Ochoa” program for Centres of Excellence in R&D (CEX2019-000910-S), from Fundació Privada Cellex, Fundació Mir-Puig, Generalitat de Catalunya through the CERCA program, la Caixa” Foundation (ID 100010434), under agreement HR18-00313, European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 754510 and Laserlab-Europe EU-H2020 (871124). JA, CV and PLA acknowledge David Merino and Oumaima Sliti for their contribution to the project. MFS and MP acknowledge fruitful discussions with C.K. Hitzenberger and E. Brunner from the Medical University of Vienna. Thanks to Dietmar Korn, Babacar Wade, Franck Martins and Jigang Lu at Imagine Eyes for their contributions to engineering the prototypes. The study was supported by the European Reference Network for Rare Eye Diseases (ERN-EYE).
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