Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

R Malik; G Chauhan; M Traylor; M Sargurupremraj; Y Okada; A Mishra; L Rutten-Jacobs; A K Giese; Sander Laan; S Gretarsdottir; CD Anderson; M Chong; Hieab Adams; T Ago; P Almgren; P Amouyel; H Ay; TM Bartz; OR Benavente; S Bevan; GB Boncoraglio; RD Brown; AS Butterworth; C Carrera; C L Carty; DI Chasman; WM Chen; JW Cole; A Correa; I Cotlarciuc; C Cruchaga; J Danesh; PIW de Bakker; AL DeStefano; M den Hoed; Q Duan; ST Engelter; GJ Falcone; RF Gottesman; RP Grewal; V Gudnason; S Gustafsson; J Haessler; TB Harris; A Hassan; AS Havulinna; SR Heckbert; EG Holliday; G Howard; FC Hsu; HI Hyacinth; Arfan Ikram; E Ingelsson; M R Irvin; XQ Jian; J Jimenez-Conde; JA Johnson; JW Jukema; M Kanai; KL Keene; BM Kissela; DO Kleindorfer; C Kooperberg; M Kubo; LA Lange; CD Langefeld; C Langenberg; LJ Launer; JM Lee; R Lemmens; D Leys; CM Lewis; WY Lin; AG Lindgren; E Lorentzen; PK Magnusson; J Maguire; A Manichaikul; PF McArdle; JF Meschia; BD Mitchell; TH Mosley; MA Nalls; T Ninomiya; MJ O'Donnell; BM Psaty; SL Pulit; K Rannikmae; AP Reiner; KM Rexrode; K Rice; SS Rich; PM Ridker; NS Rost; PM Rothwell; JI Rotter; T Rundek; RL Sacco; S Sakaue; MM Sale; V Salomaa; BR Sapkota; R Schmidt; CO Schmidt; U Schminke; P Sharma; A Slowik; CLM Sudlow; C Tanislav; T Tatlisumak; KD Taylor; VNS Thijs; G Thorleifsson; U Thorsteinsdottir; S Tiedt; S Trompet; C Tzourio; Cornelia Duijn; M Walters; NJ Wareham; S Wassertheil-Smoller; JG Wilson; KL Wiggins; Q Yang; S Yusuf; JC Bis; T Pastinen; A Ruusalepp; EE Schadt; S Koplev; JLM Bjorkegren; V Codoni; M Civelek; NL Smith; DA Tregouet; IE Christophersen; C Roselli; SA Lubitz; PT Ellinor; ES Tai; JS Kooner; N Kato; J He; P van der Harst; P Elliott; JC Chambers; F Takeuchi; AD Johnson; DK Sanghera; O Melander; C Jern; D Strbian; I Fernandez-Cadenas; WT Longstreth; A Rolfs; J Hata; D Woo; J Rosand; G Pare; JC Hopewell; D Saleheen; K Stefansson; BB Worrall; SJ Kittner; S Seshadri; M Fornage; HS Markus; JMM Howson; Y Kamatani; S Debette; M Dichgans

doi:10.1038/s41588-018-0058-3

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

R Malik, G Chauhan, M Traylor, M Sargurupremraj, Y Okada, A Mishra, L Rutten-Jacobs, A K Giese, Sander Laan, S Gretarsdottir, CD Anderson, M Chong, Hieab Adams, T Ago, P Almgren, P Amouyel, H Ay, TM Bartz, OR Benavente, S BevanGB Boncoraglio, RD Brown, AS Butterworth, C Carrera, C L Carty, DI Chasman, WM Chen, JW Cole, A Correa, I Cotlarciuc, C Cruchaga, J Danesh, PIW de Bakker, AL DeStefano, M den Hoed, Q Duan, ST Engelter, GJ Falcone, RF Gottesman, RP Grewal, V Gudnason, S Gustafsson, J Haessler, TB Harris, A Hassan, AS Havulinna, SR Heckbert, EG Holliday, G Howard, FC Hsu, HI Hyacinth, Arfan Ikram, E Ingelsson, M R Irvin, XQ Jian, J Jimenez-Conde, JA Johnson, JW Jukema, M Kanai, KL Keene, BM Kissela, DO Kleindorfer, C Kooperberg, M Kubo, LA Lange, CD Langefeld, C Langenberg, LJ Launer, JM Lee, R Lemmens, D Leys, CM Lewis, WY Lin, AG Lindgren, E Lorentzen, PK Magnusson, J Maguire, A Manichaikul, PF McArdle, JF Meschia, BD Mitchell, TH Mosley, MA Nalls, T Ninomiya, MJ O'Donnell, BM Psaty, SL Pulit, K Rannikmae, AP Reiner, KM Rexrode, K Rice, SS Rich, PM Ridker, NS Rost, PM Rothwell, JI Rotter, T Rundek, RL Sacco, S Sakaue, MM Sale, V Salomaa, BR Sapkota, R Schmidt, CO Schmidt, U Schminke, P Sharma, A Slowik, CLM Sudlow, C Tanislav, T Tatlisumak, KD Taylor, VNS Thijs, G Thorleifsson, U Thorsteinsdottir, S Tiedt, S Trompet, C Tzourio, Cornelia Duijn, M Walters, NJ Wareham, S Wassertheil-Smoller, JG Wilson, KL Wiggins, Q Yang, S Yusuf, JC Bis, T Pastinen, A Ruusalepp, EE Schadt, S Koplev, JLM Bjorkegren, V Codoni, M Civelek, NL Smith, DA Tregouet, IE Christophersen, C Roselli, SA Lubitz, PT Ellinor, ES Tai, JS Kooner, N Kato, J He, P van der Harst, P Elliott, JC Chambers, F Takeuchi, AD Johnson, DK Sanghera, O Melander, C Jern, D Strbian, I Fernandez-Cadenas, WT Longstreth, A Rolfs, J Hata, D Woo, J Rosand, G Pare, JC Hopewell, D Saleheen, K Stefansson, BB Worrall, SJ Kittner, S Seshadri, M Fornage, HS Markus, JMM Howson, Y Kamatani, S Debette, M Dichgans

Research output: Contribution to journal › Article › Academic › peer-review

1157 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	524-+
Journal	Nature Genetics
Volume	50
Issue number	4
DOIs	https://doi.org/10.1038/s41588-018-0058-3
Publication status	Published - 2018

Research programs

EMC NIHES-01-64-02
EMC NIHES-03-30-02

Access to Document

10.1038/s41588-018-0058-3

http://hdl.handle.net/1765/105229

Cite this

Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., Rutten-Jacobs, L., Giese, A. K., Laan, S., Gretarsdottir, S., Anderson, CD., Chong, M., Adams, H., Ago, T., Almgren, P., Amouyel, P., Ay, H., Bartz, TM., Benavente, OR., ... Dichgans, M. (2018). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics, 50(4), 524-+. https://doi.org/10.1038/s41588-018-0058-3

@article{4afe579c30f143fd85903264afef1160,

title = "Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes",

author = "R Malik and G Chauhan and M Traylor and M Sargurupremraj and Y Okada and A Mishra and L Rutten-Jacobs and Giese, {A K} and Sander Laan and S Gretarsdottir and CD Anderson and M Chong and Hieab Adams and T Ago and P Almgren and P Amouyel and H Ay and TM Bartz and OR Benavente and S Bevan and GB Boncoraglio and RD Brown and AS Butterworth and C Carrera and Carty, {C L} and DI Chasman and WM Chen and JW Cole and A Correa and I Cotlarciuc and C Cruchaga and J Danesh and {de Bakker}, PIW and AL DeStefano and {den Hoed}, M and Q Duan and ST Engelter and GJ Falcone and RF Gottesman and RP Grewal and V Gudnason and S Gustafsson and J Haessler and TB Harris and A Hassan and AS Havulinna and SR Heckbert and EG Holliday and G Howard and FC Hsu and HI Hyacinth and Arfan Ikram and E Ingelsson and Irvin, {M R} and XQ Jian and J Jimenez-Conde and JA Johnson and JW Jukema and M Kanai and KL Keene and BM Kissela and DO Kleindorfer and C Kooperberg and M Kubo and LA Lange and CD Langefeld and C Langenberg and LJ Launer and JM Lee and R Lemmens and D Leys and CM Lewis and WY Lin and AG Lindgren and E Lorentzen and PK Magnusson and J Maguire and A Manichaikul and PF McArdle and JF Meschia and BD Mitchell and TH Mosley and MA Nalls and T Ninomiya and MJ O'Donnell and BM Psaty and SL Pulit and K Rannikmae and AP Reiner and KM Rexrode and K Rice and SS Rich and PM Ridker and NS Rost and PM Rothwell and JI Rotter and T Rundek and RL Sacco and S Sakaue and MM Sale and V Salomaa and BR Sapkota and R Schmidt and CO Schmidt and U Schminke and P Sharma and A Slowik and CLM Sudlow and C Tanislav and T Tatlisumak and KD Taylor and VNS Thijs and G Thorleifsson and U Thorsteinsdottir and S Tiedt and S Trompet and C Tzourio and Cornelia Duijn and M Walters and NJ Wareham and S Wassertheil-Smoller and JG Wilson and KL Wiggins and Q Yang and S Yusuf and JC Bis and T Pastinen and A Ruusalepp and EE Schadt and S Koplev and JLM Bjorkegren and V Codoni and M Civelek and NL Smith and DA Tregouet and IE Christophersen and C Roselli and SA Lubitz and PT Ellinor and ES Tai and JS Kooner and N Kato and J He and {van der Harst}, P and P Elliott and JC Chambers and F Takeuchi and AD Johnson and DK Sanghera and O Melander and C Jern and D Strbian and I Fernandez-Cadenas and WT Longstreth and A Rolfs and J Hata and D Woo and J Rosand and G Pare and JC Hopewell and D Saleheen and K Stefansson and BB Worrall and SJ Kittner and S Seshadri and M Fornage and HS Markus and JMM Howson and Y Kamatani and S Debette and M Dichgans",

year = "2018",

doi = "10.1038/s41588-018-0058-3",

language = "Undefined/Unknown",

volume = "50",

pages = "524--+",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "4",

}

Malik, R, Chauhan, G, Traylor, M, Sargurupremraj, M, Okada, Y, Mishra, A, Rutten-Jacobs, L, Giese, AK, Laan, S, Gretarsdottir, S, Anderson, CD, Chong, M, Adams, H, Ago, T, Almgren, P, Amouyel, P, Ay, H, Bartz, TM, Benavente, OR, Bevan, S, Boncoraglio, GB, Brown, RD, Butterworth, AS, Carrera, C, Carty, CL, Chasman, DI, Chen, WM, Cole, JW, Correa, A, Cotlarciuc, I, Cruchaga, C, Danesh, J, de Bakker, PIW, DeStefano, AL, den Hoed, M, Duan, Q, Engelter, ST, Falcone, GJ, Gottesman, RF, Grewal, RP, Gudnason, V, Gustafsson, S, Haessler, J, Harris, TB, Hassan, A, Havulinna, AS, Heckbert, SR, Holliday, EG, Howard, G, Hsu, FC, Hyacinth, HI, Ikram, A, Ingelsson, E, Irvin, MR, Jian, XQ, Jimenez-Conde, J, Johnson, JA, Jukema, JW, Kanai, M, Keene, KL, Kissela, BM, Kleindorfer, DO, Kooperberg, C, Kubo, M, Lange, LA, Langefeld, CD, Langenberg, C, Launer, LJ, Lee, JM, Lemmens, R, Leys, D, Lewis, CM, Lin, WY, Lindgren, AG, Lorentzen, E, Magnusson, PK, Maguire, J, Manichaikul, A, McArdle, PF, Meschia, JF, Mitchell, BD, Mosley, TH, Nalls, MA, Ninomiya, T, O'Donnell, MJ, Psaty, BM, Pulit, SL, Rannikmae, K, Reiner, AP, Rexrode, KM, Rice, K, Rich, SS, Ridker, PM, Rost, NS, Rothwell, PM, Rotter, JI, Rundek, T, Sacco, RL, Sakaue, S, Sale, MM, Salomaa, V, Sapkota, BR, Schmidt, R, Schmidt, CO, Schminke, U, Sharma, P, Slowik, A, Sudlow, CLM, Tanislav, C, Tatlisumak, T, Taylor, KD, Thijs, VNS, Thorleifsson, G, Thorsteinsdottir, U, Tiedt, S, Trompet, S, Tzourio, C, Duijn, C, Walters, M, Wareham, NJ, Wassertheil-Smoller, S, Wilson, JG, Wiggins, KL, Yang, Q, Yusuf, S, Bis, JC, Pastinen, T, Ruusalepp, A, Schadt, EE, Koplev, S, Bjorkegren, JLM, Codoni, V, Civelek, M, Smith, NL, Tregouet, DA, Christophersen, IE, Roselli, C, Lubitz, SA, Ellinor, PT, Tai, ES, Kooner, JS, Kato, N, He, J, van der Harst, P, Elliott, P, Chambers, JC, Takeuchi, F, Johnson, AD, Sanghera, DK, Melander, O, Jern, C, Strbian, D, Fernandez-Cadenas, I, Longstreth, WT, Rolfs, A, Hata, J, Woo, D, Rosand, J, Pare, G, Hopewell, JC, Saleheen, D, Stefansson, K, Worrall, BB, Kittner, SJ, Seshadri, S, Fornage, M, Markus, HS, Howson, JMM, Kamatani, Y, Debette, S & Dichgans, M 2018, 'Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes', Nature Genetics, vol. 50, no. 4, pp. 524-+. https://doi.org/10.1038/s41588-018-0058-3

TY - JOUR

T1 - Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

AU - Malik, R

AU - Chauhan, G

AU - Traylor, M

AU - Sargurupremraj, M

AU - Okada, Y

AU - Mishra, A

AU - Rutten-Jacobs, L

AU - Giese, A K

AU - Laan, Sander

AU - Gretarsdottir, S

AU - Anderson, CD

AU - Chong, M

AU - Adams, Hieab

AU - Ago, T

AU - Almgren, P

AU - Amouyel, P

AU - Ay, H

AU - Bartz, TM

AU - Benavente, OR

AU - Bevan, S

AU - Boncoraglio, GB

AU - Brown, RD

AU - Butterworth, AS

AU - Carrera, C

AU - Carty, C L

AU - Chasman, DI

AU - Chen, WM

AU - Cole, JW

AU - Correa, A

AU - Cotlarciuc, I

AU - Cruchaga, C

AU - Danesh, J

AU - de Bakker, PIW

AU - DeStefano, AL

AU - den Hoed, M

AU - Duan, Q

AU - Engelter, ST

AU - Falcone, GJ

AU - Gottesman, RF

AU - Grewal, RP

AU - Gudnason, V

AU - Gustafsson, S

AU - Haessler, J

AU - Harris, TB

AU - Hassan, A

AU - Havulinna, AS

AU - Heckbert, SR

AU - Holliday, EG

AU - Howard, G

AU - Hsu, FC

AU - Hyacinth, HI

AU - Ikram, Arfan

AU - Ingelsson, E

AU - Irvin, M R

AU - Jian, XQ

AU - Jimenez-Conde, J

AU - Johnson, JA

AU - Jukema, JW

AU - Kanai, M

AU - Keene, KL

AU - Kissela, BM

AU - Kleindorfer, DO

AU - Kooperberg, C

AU - Kubo, M

AU - Lange, LA

AU - Langefeld, CD

AU - Langenberg, C

AU - Launer, LJ

AU - Lee, JM

AU - Lemmens, R

AU - Leys, D

AU - Lewis, CM

AU - Lin, WY

AU - Lindgren, AG

AU - Lorentzen, E

AU - Magnusson, PK

AU - Maguire, J

AU - Manichaikul, A

AU - McArdle, PF

AU - Meschia, JF

AU - Mitchell, BD

AU - Mosley, TH

AU - Nalls, MA

AU - Ninomiya, T

AU - O'Donnell, MJ

AU - Psaty, BM

AU - Pulit, SL

AU - Rannikmae, K

AU - Reiner, AP

AU - Rexrode, KM

AU - Rice, K

AU - Rich, SS

AU - Ridker, PM

AU - Rost, NS

AU - Rothwell, PM

AU - Rotter, JI

AU - Rundek, T

AU - Sacco, RL

AU - Sakaue, S

AU - Sale, MM

AU - Salomaa, V

AU - Sapkota, BR

AU - Schmidt, R

AU - Schmidt, CO

AU - Schminke, U

AU - Sharma, P

AU - Slowik, A

AU - Sudlow, CLM

AU - Tanislav, C

AU - Tatlisumak, T

AU - Taylor, KD

AU - Thijs, VNS

AU - Thorleifsson, G

AU - Thorsteinsdottir, U

AU - Tiedt, S

AU - Trompet, S

AU - Tzourio, C

AU - Duijn, Cornelia

AU - Walters, M

AU - Wareham, NJ

AU - Wassertheil-Smoller, S

AU - Wilson, JG

AU - Wiggins, KL

AU - Yang, Q

AU - Yusuf, S

AU - Bis, JC

AU - Pastinen, T

AU - Ruusalepp, A

AU - Schadt, EE

AU - Koplev, S

AU - Bjorkegren, JLM

AU - Codoni, V

AU - Civelek, M

AU - Smith, NL

AU - Tregouet, DA

AU - Christophersen, IE

AU - Roselli, C

AU - Lubitz, SA

AU - Ellinor, PT

AU - Tai, ES

AU - Kooner, JS

AU - Kato, N

AU - He, J

AU - van der Harst, P

AU - Elliott, P

AU - Chambers, JC

AU - Takeuchi, F

AU - Johnson, AD

AU - Sanghera, DK

AU - Melander, O

AU - Jern, C

AU - Strbian, D

AU - Fernandez-Cadenas, I

AU - Longstreth, WT

AU - Rolfs, A

AU - Hata, J

AU - Woo, D

AU - Rosand, J

AU - Pare, G

AU - Hopewell, JC

AU - Saleheen, D

AU - Stefansson, K

AU - Worrall, BB

AU - Kittner, SJ

AU - Seshadri, S

AU - Fornage, M

AU - Markus, HS

AU - Howson, JMM

AU - Kamatani, Y

AU - Debette, S

AU - Dichgans, M

PY - 2018

Y1 - 2018

U2 - 10.1038/s41588-018-0058-3

DO - 10.1038/s41588-018-0058-3

M3 - Article

SN - 1061-4036

VL - 50

SP - 524-+

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -