Abstract
Original language | Undefined/Unknown |
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Pages (from-to) | 1310-1324 |
Number of pages | 15 |
Journal | Circulation |
Volume | 128 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2013 |
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Multiethnic Meta-Analysis of Genome-Wide Association Studies in > 100 000 Subjects Identifies 23 FibrinogenAssociated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease. / Sabater-Lleal, M; Huang, J; Chasman, D et al.
In: Circulation, Vol. 128, No. 12, 2013, p. 1310-1324.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Multiethnic Meta-Analysis of Genome-Wide Association Studies in > 100 000 Subjects Identifies 23 FibrinogenAssociated Loci but No Strong Evidence of a Causal Association Between Circulating Fibrinogen and Cardiovascular Disease
AU - Sabater-Lleal, M
AU - Huang, J
AU - Chasman, D
AU - Naitza, S
AU - Dehghan, Abbas
AU - Johnson, AD
AU - Teumer, A
AU - Reiner, AP
AU - Folkersen, L
AU - Basu, Sreya
AU - Rudnicka, AR
AU - Trompet, S
AU - Malarstig, A
AU - Baumert, J
AU - Bis, JC
AU - Guo, XQ
AU - Hottenga, JJ (Jouke Jan)
AU - Shin, SY
AU - Lopez, LM
AU - Lahti, J
AU - Tanaka, T
AU - Yanek, LR
AU - Oudot-Mellakh, T
AU - Wilson, JF
AU - Navarro, P
AU - Huffman, JE
AU - Zemunik, T
AU - Redline, S
AU - Mehra, R
AU - Pulanic, D
AU - Rudan, I
AU - Wright, AF
AU - Kolcic, I
AU - Polasek, O
AU - Wild, SH
AU - Campbell, H
AU - Curb, JD
AU - Wallace, R
AU - Liu, SM (Simin)
AU - Eaton, CB
AU - Becker, DM
AU - Becker, LC
AU - Bandinelli, S
AU - Raikkonen, K
AU - Widen, E
AU - Palotie, A
AU - Fornage, M
AU - Green, D
AU - Gross, M
AU - Davies, G
AU - Harris, SE
AU - Liewald, DC
AU - Starr, JM
AU - Williams, FMK
AU - Grant, PJ
AU - Spector, TD
AU - Strawbridge, RJ
AU - Silveira, A
AU - Sennblad, B
AU - Rivadeneira, Fernando
AU - Uitterlinden, André
AU - Franco Duran, OH
AU - Hofman, Bert
AU - Dongen, Jacques
AU - Willemsen, G
AU - Boomsma, DI
AU - Yao, JJ
AU - Jenny, NS
AU - Haritunians, T
AU - McKnight, B
AU - Lumley, T
AU - Taylor, KD
AU - Rotter, JI
AU - Psaty, BM
AU - Peters, A
AU - Gieger, C
AU - Illig, T
AU - Grotevendt, A
AU - Homuth, G
AU - Volzke, H
AU - Kocher, T
AU - Goel, A
AU - Franzosi, MG
AU - Seedorf, U
AU - Clarke, R
AU - Steri, M
AU - Tarasov, KV
AU - Sanna, S
AU - Schlessinger, D
AU - Stott, DJ
AU - Sattar, N
AU - Buckley, BM
AU - Rumley, A
AU - Lowe, GD
AU - McArdle, WL
AU - Chen, MH
AU - Tofler, GH
AU - Song, J
AU - Boerwinkle, E
AU - Folsom, AR
AU - Rose, LM
AU - Franco-Cereceda, A
AU - Teichert, Martina
AU - Ikram, Arfan
AU - Mosley, TH
AU - Bevan, S
AU - Dichgans, M
AU - Rothwell, PM
AU - Sudlow, CLM
AU - Hopewell, JC
AU - Chambers, JC
AU - Saleheen, D
AU - Kooner, JS
AU - Danesh, J
AU - Nelson, CP
AU - Erdmann, J
AU - Reilly, MP
AU - Kathiresan, S
AU - Schunkert, H
AU - Morange, PE
AU - Ferrucci, L
AU - Eriksson, JG
AU - Jacobs, D
AU - Deary, IJ
AU - Soranzo, N
AU - Witteman, JCM
AU - de Geus, EJC
AU - Tracy, RP
AU - Hayward, C
AU - Koenig, W
AU - Cucca, F
AU - Jukema, JW
AU - Eriksson, P
AU - Seshadri, S
AU - Markus, HS
AU - Watkins, H
AU - Samani, NJ
AU - Wallaschofski, H
AU - Smith, NL
AU - Tregouet, D
AU - Ridker, PM
AU - Tang, WH
AU - Strachan, DP
AU - Hamsten, A
AU - O'Donnell, CJ
PY - 2013
Y1 - 2013
N2 - Background Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (<2%) of its variation. Methods and Results We conducted a meta-analysis of 28 genome-wide association studies including >90 000 subjects of European ancestry, the first genome-wide association meta-analysis of fibrinogen levels in 7 studies in blacks totaling 8289 samples, and a genome-wide association study in Hispanics totaling 1366 samples. Evaluation for association of single-nucleotide polymorphisms with clinical outcomes included a total of 40 695 cases and 85 582 controls for coronary artery disease, 4752 cases Conclusions We identify 23 robustly associated fibrinogen loci, 15 of which are new. Clinical outcome analysis of these loci does not support a causal relationship between circulating levels of fibrinogen and coronary artery disease, stroke, or venous thromboembolism.
AB - Background Estimates of the heritability of plasma fibrinogen concentration, an established predictor of cardiovascular disease, range from 34% to 50%. Genetic variants so far identified by genome-wide association studies explain only a small proportion (<2%) of its variation. Methods and Results We conducted a meta-analysis of 28 genome-wide association studies including >90 000 subjects of European ancestry, the first genome-wide association meta-analysis of fibrinogen levels in 7 studies in blacks totaling 8289 samples, and a genome-wide association study in Hispanics totaling 1366 samples. Evaluation for association of single-nucleotide polymorphisms with clinical outcomes included a total of 40 695 cases and 85 582 controls for coronary artery disease, 4752 cases Conclusions We identify 23 robustly associated fibrinogen loci, 15 of which are new. Clinical outcome analysis of these loci does not support a causal relationship between circulating levels of fibrinogen and coronary artery disease, stroke, or venous thromboembolism.
U2 - 10.1161/CIRCULATIONAHA.113.002251
DO - 10.1161/CIRCULATIONAHA.113.002251
M3 - Article
VL - 128
SP - 1310
EP - 1324
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 12
ER -