Multifactorial Diseases of the Heart, Kidneys, Lungs, and Liver and Incident Cancer: Epidemiology and Shared Mechanisms

Canxia Shi, Sanne de Wit, Emina Učambarlić, George Markousis-Mavrogenis, Elles M. Screever, Wouter C. Meijers, Rudolf A. de Boer*, Joseph Pierre Aboumsallem*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

8 Citations (Scopus)
35 Downloads (Pure)


Within the aging population, the frequency of cancer is increasing dramatically. In addition, multiple genetic and environmental factors lead to common multifactorial diseases, including cardiovascular disease, chronic kidney disease, chronic obstructive pulmonary disease, and metabolic-associated fatty liver disease. In recent years, there has been a growing awareness of the connection between cancer and multifactorial diseases, as well as how one can affect the other, resulting in a vicious cycle. Although the exact mechanistic explanations behind this remain to be fully explored, some progress has been made in uncovering the common pathologic mechanisms. In this review, we focus on the nature of the link between cancer and common multifactorial conditions, as well as specific shared mechanisms, some of which may represent either preventive or therapeutic targets. Rather than organ-specific interactions, we herein focus on the shared mechanisms among the multifactorial diseases, which may explain the increased cancer risk. More research on this subject will highlight the significance of developing new drugs that target multiple systems rather than just one disease.

Original languageEnglish
Article number729
Issue number3
Publication statusPublished - Feb 2023

Bibliographical note

Funding Information:
This work was supported by a grant from the European Research Council (ERC CoG 818715; SECRETE-HF) and furthermore by grants from the Dutch Heart Foundation (CVON SHE-PREDICTS-HF; grant 2017-21; CVON RED-CVD; grant 2017-11; CVON PREDICT2; grant 2018-30; CVON DOUBLE DOSE; grant 2020B005), by a grant from the Leducq Foundation Cure PhosphoLambaN induced Cardiomyopathy (Cure-PLaN). Canxia Shi is supported by a scholarship from the China Scholarship Council (CSC number: 201806170057). This work was also supported by grants from the Dutch Heart Foundation (Dekker grant 03-005-2021-T005) and the Mandema-Stipendium of the Junior Scientific Masterclass 2020-10 of the University Medical Center Groningen, both to Dr. Wouter C. Meijers.

Publisher Copyright:
© 2023 by the authors.


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