Multimodal treatment for colorectal liver metastases: A toolbox for clinicians

Sheraz Yaqub; Anne Longva; Jon Helge Angelsen; Kristoffer W. Brudvik; Ulrik Carling; Bjørn Edwin; Åsmund A. Fretland; Dirk J. Grünhagen; Pål Dag Line; Bård I. Røsok; Tor M. Smedman; Ernesto Sparrelid; Trygve Syversveen; Olaug Villanger; Kristoffer Lassen

doi:10.1177/14574969251333524

Multimodal treatment for colorectal liver metastases: A toolbox for clinicians

Sheraz Yaqub^*
, Anne Longva
, Jon Helge Angelsen
, Kristoffer W. Brudvik
, Ulrik Carling
, Bjørn Edwin
, Åsmund A. Fretland
, Dirk J. Grünhagen
, Pål Dag Line
, Bård I. Røsok
, Tor M. Smedman
, Ernesto Sparrelid
, Trygve Syversveen
, Olaug Villanger
, Kristoffer Lassen

^*Corresponding author for this work

Surgery

Oslo University Hospital
University of Oslo
University of Bergen
Karolinska University Hospital
University of Tromsø – The Arctic University of Norway

Research output: Contribution to journal › Review article › Academic › peer-review

2 Citations (Scopus)

133 Downloads (Pure)

Abstract

Colorectal cancer is the second most common cause of cancer-related death worldwide, and liver metastases are the leading cause of mortality in these patients. Surgical innovations combined with modern systemic chemotherapy have improved 5-year overall survival rates. This review aims to equip non-hepatobiliary surgeons with a comprehensive toolbox for the diagnosis and management of colorectal liver metastases. It covers the current landscape of diagnostic workup, including imaging modalities and biomarkers, and reviews the surgical and nonsurgical treatment options. This guide attempts to enhance multidisciplinary care for patients with colorectal liver metastases by integrating evidence-based practices with innovative strategies, which can improve outcomes and survival.

Original language	English
Pages (from-to)	126-134
Number of pages	9
Journal	Scandinavian Journal of Surgery
Volume	114
Issue number	2 Special issue: Metastasis surgery
Early online date	18 Apr 2025
DOIs	https://doi.org/10.1177/14574969251333524
Publication status	Published - Jun 2025

Bibliographical note

Publisher Copyright:
© The Finnish Surgical Society 2025. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1177/14574969251333524Licence: CC BY

Multimodal treatment for colorectal liver metastasesFinal published version, 726 KBLicence: CC BY

Cite this

Yaqub, S., Longva, A., Angelsen, J. H., Brudvik, K. W., Carling, U., Edwin, B., Fretland, Å. A., Grünhagen, D. J., Line, P. D., Røsok, B. I., Smedman, T. M., Sparrelid, E., Syversveen, T., Villanger, O., & Lassen, K. (2025). Multimodal treatment for colorectal liver metastases: A toolbox for clinicians. Scandinavian Journal of Surgery, 114(2 Special issue: Metastasis surgery), 126-134. https://doi.org/10.1177/14574969251333524

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title = "Multimodal treatment for colorectal liver metastases: A toolbox for clinicians",

abstract = "Colorectal cancer is the second most common cause of cancer-related death worldwide, and liver metastases are the leading cause of mortality in these patients. Surgical innovations combined with modern systemic chemotherapy have improved 5-year overall survival rates. This review aims to equip non-hepatobiliary surgeons with a comprehensive toolbox for the diagnosis and management of colorectal liver metastases. It covers the current landscape of diagnostic workup, including imaging modalities and biomarkers, and reviews the surgical and nonsurgical treatment options. This guide attempts to enhance multidisciplinary care for patients with colorectal liver metastases by integrating evidence-based practices with innovative strategies, which can improve outcomes and survival.",

author = "Sheraz Yaqub and Anne Longva and Angelsen, \{Jon Helge\} and Brudvik, \{Kristoffer W.\} and Ulrik Carling and Bj{\o}rn Edwin and Fretland, \{{\AA}smund A.\} and Gr{\"u}nhagen, \{Dirk J.\} and Line, \{P{\aa}l Dag\} and R{\o}sok, \{B{\aa}rd I.\} and Smedman, \{Tor M.\} and Ernesto Sparrelid and Trygve Syversveen and Olaug Villanger and Kristoffer Lassen",

note = "Publisher Copyright: {\textcopyright} The Finnish Surgical Society 2025. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).",

year = "2025",

month = jun,

doi = "10.1177/14574969251333524",

language = "English",

volume = "114",

pages = "126--134",

number = "2 Special issue: Metastasis surgery",

}

Yaqub, S, Longva, A, Angelsen, JH, Brudvik, KW, Carling, U, Edwin, B, Fretland, ÅA, Grünhagen, DJ, Line, PD, Røsok, BI, Smedman, TM, Sparrelid, E, Syversveen, T, Villanger, O & Lassen, K 2025, 'Multimodal treatment for colorectal liver metastases: A toolbox for clinicians', Scandinavian Journal of Surgery, vol. 114, no. 2 Special issue: Metastasis surgery, pp. 126-134. https://doi.org/10.1177/14574969251333524

TY - JOUR

T1 - Multimodal treatment for colorectal liver metastases

T2 - A toolbox for clinicians

AU - Yaqub, Sheraz

AU - Longva, Anne

AU - Angelsen, Jon Helge

AU - Brudvik, Kristoffer W.

AU - Carling, Ulrik

AU - Edwin, Bjørn

AU - Fretland, Åsmund A.

AU - Grünhagen, Dirk J.

AU - Line, Pål Dag

AU - Røsok, Bård I.

AU - Smedman, Tor M.

AU - Sparrelid, Ernesto

AU - Syversveen, Trygve

AU - Villanger, Olaug

AU - Lassen, Kristoffer

N1 - Publisher Copyright: © The Finnish Surgical Society 2025. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PY - 2025/6

Y1 - 2025/6

N2 - Colorectal cancer is the second most common cause of cancer-related death worldwide, and liver metastases are the leading cause of mortality in these patients. Surgical innovations combined with modern systemic chemotherapy have improved 5-year overall survival rates. This review aims to equip non-hepatobiliary surgeons with a comprehensive toolbox for the diagnosis and management of colorectal liver metastases. It covers the current landscape of diagnostic workup, including imaging modalities and biomarkers, and reviews the surgical and nonsurgical treatment options. This guide attempts to enhance multidisciplinary care for patients with colorectal liver metastases by integrating evidence-based practices with innovative strategies, which can improve outcomes and survival.

AB - Colorectal cancer is the second most common cause of cancer-related death worldwide, and liver metastases are the leading cause of mortality in these patients. Surgical innovations combined with modern systemic chemotherapy have improved 5-year overall survival rates. This review aims to equip non-hepatobiliary surgeons with a comprehensive toolbox for the diagnosis and management of colorectal liver metastases. It covers the current landscape of diagnostic workup, including imaging modalities and biomarkers, and reviews the surgical and nonsurgical treatment options. This guide attempts to enhance multidisciplinary care for patients with colorectal liver metastases by integrating evidence-based practices with innovative strategies, which can improve outcomes and survival.

UR - https://www.scopus.com/pages/publications/105002953035

U2 - 10.1177/14574969251333524

DO - 10.1177/14574969251333524

M3 - Review article

C2 - 40247715

AN - SCOPUS:105002953035

SN - 1457-4969

VL - 114

SP - 126

EP - 134

JO - Scandinavian Journal of Surgery

JF - Scandinavian Journal of Surgery

IS - 2 Special issue: Metastasis surgery

ER -

Multimodal treatment for colorectal liver metastases: A toolbox for clinicians

Abstract

Bibliographical note

UN SDGs

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