Multimodality Imaging Evaluation of Coronary IgG4-Related Disease: A “Tumor-Like” Cardiac Lesion

Ludovica R.M. Lanzafame; Maria Ludovica Carerj; Giovanna Rizzo; Fabio Minutoli; Giuseppe M. Bucolo; Natasha Irrera; Giuseppe Muscogiuri; Sandro Sironi; Alfredo Blandino; Tommaso D’Angelo

doi:10.3390/diagnostics12112814

Multimodality Imaging Evaluation of Coronary IgG4-Related Disease: A “Tumor-Like” Cardiac Lesion

Ludovica R.M. Lanzafame
, Maria Ludovica Carerj
, Giovanna Rizzo
, Fabio Minutoli
, Giuseppe M. Bucolo
, Natasha Irrera
, Giuseppe Muscogiuri
, Sandro Sironi
, Alfredo Blandino
, Tommaso D’Angelo^*

^*Corresponding author for this work

Radiology & Nuclear Medicine

University of Messina
IRCCS Centro Cardiologico S.P.A. Fondazione Monzino - Milano
IRCCS Istituto Auxologico Italiano - Milano
Papa Giovanni XXIII Hospital

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

103 Downloads (Pure)

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibro-inflammatory disorder. Coronary IgG4-RD has been scarcely reported and may present as “tumor-like” lesions. These pseudo-masses may be underdiagnosed mainly due to a vague clinical picture that can vary from complete lack of symptoms to acute coronary syndrome or sudden cardiac death. Early recognition of coronary IgG4-RD is essential to monitor disease activity and prevent life-threatening complications. We report a comprehensive non-invasive imaging evaluation of a patient affected by coronary IgG4-RD, which was diagnosed as an incidental finding during routine pre-laparoscopic cholecystectomy checkup. Non-invasive imaging revealed the presence of a peri-coronary soft-tissue mass that was stable at 12 months follow-up.

Original language	English
Article number	2814
Journal	Diagnostics
Volume	12
Issue number	11
DOIs	https://doi.org/10.3390/diagnostics12112814
Publication status	Published - 16 Nov 2022

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title = "Multimodality Imaging Evaluation of Coronary IgG4-Related Disease: A “Tumor-Like” Cardiac Lesion",

abstract = "Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibro-inflammatory disorder. Coronary IgG4-RD has been scarcely reported and may present as “tumor-like” lesions. These pseudo-masses may be underdiagnosed mainly due to a vague clinical picture that can vary from complete lack of symptoms to acute coronary syndrome or sudden cardiac death. Early recognition of coronary IgG4-RD is essential to monitor disease activity and prevent life-threatening complications. We report a comprehensive non-invasive imaging evaluation of a patient affected by coronary IgG4-RD, which was diagnosed as an incidental finding during routine pre-laparoscopic cholecystectomy checkup. Non-invasive imaging revealed the presence of a peri-coronary soft-tissue mass that was stable at 12 months follow-up.",

author = "Lanzafame, \{Ludovica R.M.\} and Carerj, \{Maria Ludovica\} and Giovanna Rizzo and Fabio Minutoli and Bucolo, \{Giuseppe M.\} and Natasha Irrera and Giuseppe Muscogiuri and Sandro Sironi and Alfredo Blandino and Tommaso D{\textquoteright}Angelo",

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month = nov,

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doi = "10.3390/diagnostics12112814",

language = "English",

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T1 - Multimodality Imaging Evaluation of Coronary IgG4-Related Disease

T2 - A “Tumor-Like” Cardiac Lesion

AU - Lanzafame, Ludovica R.M.

AU - Carerj, Maria Ludovica

AU - Rizzo, Giovanna

AU - Minutoli, Fabio

AU - Bucolo, Giuseppe M.

AU - Irrera, Natasha

AU - Muscogiuri, Giuseppe

AU - Sironi, Sandro

AU - Blandino, Alfredo

AU - D’Angelo, Tommaso

PY - 2022/11/16

Y1 - 2022/11/16

N2 - Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibro-inflammatory disorder. Coronary IgG4-RD has been scarcely reported and may present as “tumor-like” lesions. These pseudo-masses may be underdiagnosed mainly due to a vague clinical picture that can vary from complete lack of symptoms to acute coronary syndrome or sudden cardiac death. Early recognition of coronary IgG4-RD is essential to monitor disease activity and prevent life-threatening complications. We report a comprehensive non-invasive imaging evaluation of a patient affected by coronary IgG4-RD, which was diagnosed as an incidental finding during routine pre-laparoscopic cholecystectomy checkup. Non-invasive imaging revealed the presence of a peri-coronary soft-tissue mass that was stable at 12 months follow-up.

AB - Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated fibro-inflammatory disorder. Coronary IgG4-RD has been scarcely reported and may present as “tumor-like” lesions. These pseudo-masses may be underdiagnosed mainly due to a vague clinical picture that can vary from complete lack of symptoms to acute coronary syndrome or sudden cardiac death. Early recognition of coronary IgG4-RD is essential to monitor disease activity and prevent life-threatening complications. We report a comprehensive non-invasive imaging evaluation of a patient affected by coronary IgG4-RD, which was diagnosed as an incidental finding during routine pre-laparoscopic cholecystectomy checkup. Non-invasive imaging revealed the presence of a peri-coronary soft-tissue mass that was stable at 12 months follow-up.

UR - https://www.scopus.com/pages/publications/85149486449

U2 - 10.3390/diagnostics12112814

DO - 10.3390/diagnostics12112814

M3 - Article

C2 - 36428873

AN - SCOPUS:85149486449

SN - 2075-4418

VL - 12

JO - Diagnostics

JF - Diagnostics

IS - 11

M1 - 2814

ER -

Multimodality Imaging Evaluation of Coronary IgG4-Related Disease: A “Tumor-Like” Cardiac Lesion

Abstract

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