Multipotent mesenchymal stromal cells in liver cancer: Implications for tumor biology and therapy

PY Hernanda; Alexander Pedroza Gonzalez; Dave Sprengers; Maikel Peppelenbosch; Qiuwei Pan

doi:10.1016/j.bbcan.2014.08.008

Multipotent mesenchymal stromal cells in liver cancer: Implications for tumor biology and therapy

PY Hernanda, Alexander Pedroza Gonzalez, Dave Sprengers, Maikel Peppelenbosch, Qiuwei Pan

Gastroenterology & Hepatology

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

Remodeling of tumor microenvironment is a hallmark in the pathogenesis of liver cancer. Being a pivotal part of tumor stroma, multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells (MSCs), are recruited and enriched in liver tumors. Owing to their tumor tropism, MSCs are now emerging as vehicles for anticancer drug/gene delivery against liver cancer. However, the exact impact of MSCs on liver cancer remains elusive, as a variety of effects of these cells that have been reported included a plethora of tumor-promoting effects and anti-oncogenic properties. This review aims to dissect the mechanistic insight regarding this observed discrepancy in different experimental settings of liver cancer. Furthermore, we call for caution using MSCs to treat liver cancer or even premalignant liver diseases, before conclusive evidence for safety and efficacy having been obtained. (C) 2014 Elsevier B.V. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	439-445
Number of pages	7
Journal	Biochimica et Biophysica Acta-Reviews on Cancer
Volume	1846
Issue number	2
DOIs	https://doi.org/10.1016/j.bbcan.2014.08.008
Publication status	Published - 2014

Research programs

EMC MM-04-20-01
EMC MM-04-20-02-A

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.bbcan.2014.08.008

Cite this

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title = "Multipotent mesenchymal stromal cells in liver cancer: Implications for tumor biology and therapy",

abstract = "Remodeling of tumor microenvironment is a hallmark in the pathogenesis of liver cancer. Being a pivotal part of tumor stroma, multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells (MSCs), are recruited and enriched in liver tumors. Owing to their tumor tropism, MSCs are now emerging as vehicles for anticancer drug/gene delivery against liver cancer. However, the exact impact of MSCs on liver cancer remains elusive, as a variety of effects of these cells that have been reported included a plethora of tumor-promoting effects and anti-oncogenic properties. This review aims to dissect the mechanistic insight regarding this observed discrepancy in different experimental settings of liver cancer. Furthermore, we call for caution using MSCs to treat liver cancer or even premalignant liver diseases, before conclusive evidence for safety and efficacy having been obtained. (C) 2014 Elsevier B.V. All rights reserved.",

author = "PY Hernanda and {Pedroza Gonzalez}, Alexander and Dave Sprengers and Maikel Peppelenbosch and Qiuwei Pan",

year = "2014",

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T1 - Multipotent mesenchymal stromal cells in liver cancer: Implications for tumor biology and therapy

AU - Hernanda, PY

AU - Pedroza Gonzalez, Alexander

AU - Sprengers, Dave

AU - Peppelenbosch, Maikel

AU - Pan, Qiuwei

PY - 2014

Y1 - 2014

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AB - Remodeling of tumor microenvironment is a hallmark in the pathogenesis of liver cancer. Being a pivotal part of tumor stroma, multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells (MSCs), are recruited and enriched in liver tumors. Owing to their tumor tropism, MSCs are now emerging as vehicles for anticancer drug/gene delivery against liver cancer. However, the exact impact of MSCs on liver cancer remains elusive, as a variety of effects of these cells that have been reported included a plethora of tumor-promoting effects and anti-oncogenic properties. This review aims to dissect the mechanistic insight regarding this observed discrepancy in different experimental settings of liver cancer. Furthermore, we call for caution using MSCs to treat liver cancer or even premalignant liver diseases, before conclusive evidence for safety and efficacy having been obtained. (C) 2014 Elsevier B.V. All rights reserved.

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