Multipotent mesenchymal stromal cells in liver cancer: Implications for tumor biology and therapy

PY Hernanda, Alexander Pedroza Gonzalez, Dave Sprengers, Maikel Peppelenbosch, Qiuwei Pan

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)

Abstract

Remodeling of tumor microenvironment is a hallmark in the pathogenesis of liver cancer. Being a pivotal part of tumor stroma, multipotent mesenchymal stromal cells (MSCs), also known as mesenchymal stem cells (MSCs), are recruited and enriched in liver tumors. Owing to their tumor tropism, MSCs are now emerging as vehicles for anticancer drug/gene delivery against liver cancer. However, the exact impact of MSCs on liver cancer remains elusive, as a variety of effects of these cells that have been reported included a plethora of tumor-promoting effects and anti-oncogenic properties. This review aims to dissect the mechanistic insight regarding this observed discrepancy in different experimental settings of liver cancer. Furthermore, we call for caution using MSCs to treat liver cancer or even premalignant liver diseases, before conclusive evidence for safety and efficacy having been obtained. (C) 2014 Elsevier B.V. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)439-445
Number of pages7
JournalBiochimica et Biophysica Acta-Reviews on Cancer
Volume1846
Issue number2
DOIs
Publication statusPublished - 2014

Research programs

  • EMC MM-04-20-01
  • EMC MM-04-20-02-A

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