N-Terminal Pro-B-Type Natriuretic Peptide and Its Relationship With Cardiac Function in Adults With Congenital Heart Disease

Jannet Eindhoven, Annemien van den Bosch, Titia Ruys, Petra Opic, Judith Cuypers, Jackie Mcghie, Maarten Witsenburg, Eric Boersma, Jolien Roos - Hesselink

Research output: Contribution to journalArticleAcademicpeer-review

86 Citations (Scopus)

Abstract

Objectives The aim of this study was to determine the value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in adults with congenital heart disease (CHD) and investigate its relationship with ventricular function and exercise capacity. Background NT-proBNP may detect early deterioration in cardiac function. Methods In this cross-sectional study, extensive echocardiography, exercise testing, and NT-proBNP measurements were performed on the same day in consecutive adult patients with CHD. Results In total, 475 patients were included in this study (mean age of 34 +/- 12 years, 57% male, 90% New York Heart Association class I). The median NT-proBNP level was 15.1 pmol/l (interquartile range [IQR]: 7.1 to 31.3 pmol/l), and the NT-proBNP level was >14 pmol/l in 53% of patients. The highest NT-proBNP levels were observed in patients with Fontan circulation (36.1 pmol/l [IQR: 14.4 to 103.8 pmol/l]) and a systemic right ventricle (RV) (31.1 pmol/l [IQR: 21.8 to 56.0 pmol/l]), and the lo Conclusions NT-proBNP levels in adults with CHD clearly differ by diagnosis and are related to echocardiographic parameters and exercise capacity. Disease-specific correlations contribute to the understanding of the main hemodynamic problems per diagnosis. Follow-up data are needed to elucidate the additional prognostic value. (c) 2013 by the American College of Cardiology Foundation
Original languageUndefined/Unknown
Pages (from-to)1203-1212
Number of pages10
JournalJournal of the American College of Cardiology
Volume62
Issue number13
DOIs
Publication statusPublished - 2013

Research programs

  • EMC COEUR-09

Cite this