Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies

Joop J.P. Kouijzer; Daniëlle J. Noordermeer; Wouter J. van Leeuwen; Nelianne J. Verkaik; Kirby R. Lattwein

doi:10.3389/fcell.2022.995508

Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies

Joop J.P. Kouijzer^*, Daniëlle J. Noordermeer, Wouter J. van Leeuwen, Nelianne J. Verkaik, Kirby R. Lattwein

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

1 Downloads (Pure)

Abstract

Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is increasing and mortality has not significantly improved despite technological advances. This review provides an updated overview using recent literature on the clinical presentation, diagnosis, imaging, causative pathogens, treatment, and outcomes in native valve, prosthetic valve, and cardiac device-related IE. In addition, the experimental approaches used in IE research to improve the understanding of disease mechanisms and the current diagnostic pipelines are discussed, as well as potential innovative diagnostic and therapeutic strategies. This will ultimately help towards deriving better diagnostic tools and treatments to improve IE patient outcomes.

Original language	English
Article number	995508
Journal	Frontiers in Cell and Developmental Biology
Volume	10
DOIs	https://doi.org/10.3389/fcell.2022.995508
Publication status	Published - 3 Oct 2022

Bibliographical note

Funding Information:
This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 805308).

Publisher Copyright: Copyright © 2022 Kouijzer, Noordermeer, van Leeuwen, Verkaik and Lattwein.

Access to Document

10.3389/fcell.2022.995508Licence: CC BY

fcell-10-995508Final published version, 2.3 MBLicence: CC BY

Cite this

@article{e9ee624a0a444d8f8eedf89b7f851abd,

title = "Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies",

abstract = "Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is increasing and mortality has not significantly improved despite technological advances. This review provides an updated overview using recent literature on the clinical presentation, diagnosis, imaging, causative pathogens, treatment, and outcomes in native valve, prosthetic valve, and cardiac device-related IE. In addition, the experimental approaches used in IE research to improve the understanding of disease mechanisms and the current diagnostic pipelines are discussed, as well as potential innovative diagnostic and therapeutic strategies. This will ultimately help towards deriving better diagnostic tools and treatments to improve IE patient outcomes.",

author = "Kouijzer, {Joop J.P.} and Noordermeer, {Dani{\"e}lle J.} and {van Leeuwen}, {Wouter J.} and Verkaik, {Nelianne J.} and Lattwein, {Kirby R.}",

note = "Funding Information: This project has received funding from the European Research Council (ERC) under the European Union{\textquoteright}s Horizon 2020 research and innovation program (grant agreement 805308). Publisher Copyright: Copyright {\textcopyright} 2022 Kouijzer, Noordermeer, van Leeuwen, Verkaik and Lattwein.",

year = "2022",

month = oct,

day = "3",

doi = "10.3389/fcell.2022.995508",

language = "English",

volume = "10",

journal = "Frontiers in Cell and Developmental Biology",

issn = "2296-634X",

publisher = "Frontiers Media S.A.",

}

Native valve, prosthetic valve, and cardiac device-related infective endocarditis : A review and update on current innovative diagnostic and therapeutic strategies. / Kouijzer, Joop J.P.; Noordermeer, Daniëlle J.; van Leeuwen, Wouter J. et al.

In: Frontiers in Cell and Developmental Biology, Vol. 10, 995508, 03.10.2022.

Research output: Contribution to journal › Review article › Academic › peer-review

TY - JOUR

T1 - Native valve, prosthetic valve, and cardiac device-related infective endocarditis

T2 - A review and update on current innovative diagnostic and therapeutic strategies

AU - Kouijzer, Joop J.P.

AU - Noordermeer, Daniëlle J.

AU - van Leeuwen, Wouter J.

AU - Verkaik, Nelianne J.

AU - Lattwein, Kirby R.

N1 - Funding Information: This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 805308). Publisher Copyright: Copyright © 2022 Kouijzer, Noordermeer, van Leeuwen, Verkaik and Lattwein.

PY - 2022/10/3

Y1 - 2022/10/3

N2 - Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is increasing and mortality has not significantly improved despite technological advances. This review provides an updated overview using recent literature on the clinical presentation, diagnosis, imaging, causative pathogens, treatment, and outcomes in native valve, prosthetic valve, and cardiac device-related IE. In addition, the experimental approaches used in IE research to improve the understanding of disease mechanisms and the current diagnostic pipelines are discussed, as well as potential innovative diagnostic and therapeutic strategies. This will ultimately help towards deriving better diagnostic tools and treatments to improve IE patient outcomes.

AB - Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is increasing and mortality has not significantly improved despite technological advances. This review provides an updated overview using recent literature on the clinical presentation, diagnosis, imaging, causative pathogens, treatment, and outcomes in native valve, prosthetic valve, and cardiac device-related IE. In addition, the experimental approaches used in IE research to improve the understanding of disease mechanisms and the current diagnostic pipelines are discussed, as well as potential innovative diagnostic and therapeutic strategies. This will ultimately help towards deriving better diagnostic tools and treatments to improve IE patient outcomes.

UR - http://www.scopus.com/inward/record.url?scp=85139931671&partnerID=8YFLogxK

U2 - 10.3389/fcell.2022.995508

DO - 10.3389/fcell.2022.995508

M3 - Review article

AN - SCOPUS:85139931671

VL - 10

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

SN - 2296-634X

M1 - 995508

ER -

Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this