Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies

Joop J.P. Kouijzer*, Daniëlle J. Noordermeer, Wouter J. van Leeuwen, Nelianne J. Verkaik, Kirby R. Lattwein

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

1 Downloads (Pure)

Abstract

Infective endocarditis (IE) is a life-threatening microbial infection of native and prosthetic heart valves, endocardial surface, and/or indwelling cardiac device. Prevalence of IE is increasing and mortality has not significantly improved despite technological advances. This review provides an updated overview using recent literature on the clinical presentation, diagnosis, imaging, causative pathogens, treatment, and outcomes in native valve, prosthetic valve, and cardiac device-related IE. In addition, the experimental approaches used in IE research to improve the understanding of disease mechanisms and the current diagnostic pipelines are discussed, as well as potential innovative diagnostic and therapeutic strategies. This will ultimately help towards deriving better diagnostic tools and treatments to improve IE patient outcomes.

Original languageEnglish
Article number995508
JournalFrontiers in Cell and Developmental Biology
Volume10
DOIs
Publication statusPublished - 3 Oct 2022

Bibliographical note

Funding Information:
This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 805308).

Publisher Copyright: Copyright © 2022 Kouijzer, Noordermeer, van Leeuwen, Verkaik and Lattwein.

Fingerprint

Dive into the research topics of 'Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies'. Together they form a unique fingerprint.

Cite this