Natural History of Coronary Atherosclerosis by Multislice Computed Tomography

Elina Papadopoulou, Lisan Neefjes, Hector Garcia Garcia, Willem jan Flu, Alexia Rossi, Anoeshka Dharampal, PH Kitslaar, Nico Mollet, S Veldhof, Koen Nieman, GW Stone, PWJC (Patrick) Serruys, Gabriel Krestin, Pim Feijter

Research output: Contribution to journalArticleAcademic

117 Citations (Scopus)


OBJECTIVES This study sought to analyze the natural history of coronary atherosclerosis by multislice computed tomography (MSCT) and assess the serial changes in coronary plaque burden, lumen dimensions, and arterial remodeling. BACKGROUND MSCT can comprehensively assess coronary atherosclerosis by combining lumen and plaque size parameters. METHODS Thirty-two patients with acute coronary syndromes underwent 64-slice computed tomography angiography after percutaneous coronary intervention at baseline and after a median of 39 months. All patients received contemporary medical treatment. All available coronary segments in every subject were analyzed. The progression of atherosclerosis per segment and per patient was assessed by means of change in percent atheroma volume (PAV), change in normalized total atheroma volume (TAVnorm), and RESULTS The PAV did not change significantly (-0.15 +/- 3.64%, p = 0.72). The mean change in TAVnorm was 47.36 +/- 143.24 mm(3) (p = 0.071), and the % change in TAV was 6.7% (p = 0.029). The MLD and MLA increased by 0.15 mm (-0.09 to 0.24, p = 0.039) and 0.52 mm(2) (-0.38 to 1.04, p = 0.034) respectively, which was accompanied by vessel enlargement, with 53% of the patients showing expansive positive remodeling. Patients with clinical events had a larger TAVnorm at baseline (969.72 mm(3) vs. 810 CONCLUSIONS MSCT can assess the progression of coronary atherosclerosis and may be used for noninvasive monitoring of pharmacological interventions in coronary artery disease. (PROSPECT: An Imaging Study in Patients With Unstable Atherosclerotic Lesions; NCT00180466) (J Am Coll Cardiol Img 2012;5:528-37) 0 2012 by the American College of Cardiology Foundation
Original languageUndefined/Unknown
Pages (from-to)S28-S37
JournalJACC-cardiovascular imaging
Issue number3
Publication statusPublished - 2012

Research programs

  • EMC COEUR-09
  • EMC NIHES-03-30-01

Cite this