Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study

Noor Samuels; Rob van de Graaf; Jasper V. Been; Rogier C. J. de Jonge; Lidwien M. Hanff; Rene M. H. Wijnen; Rene F. Kornelisse; Irwin K. M. Reiss; Marijn J. Vermeulen

doi:10.1038/srep31643

Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study

Noor Samuels, Rob van de Graaf, Jasper V. Been, Rogier C. J. de Jonge, Lidwien M. Hanff, Rene M. H. Wijnen, Rene F. Kornelisse, Irwin K. M. Reiss, Marijn J. Vermeulen

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Abstract

Evidence on the clinical effectiveness of probiotics in the prevention of necrotising enterocolitis (NEC) in preterm infants is conflicting and cohort studies lacked adjustment for time trend and feeding type. This study investigated the association between the introduction of routine probiotics (Lactobacillus acidophilus and Bifidobacterium bifidum; Infloran (R)) on the primary outcome 'NEC or death'. Preterm infants (gestational age

Original language	English
Number of pages	10
Journal	Scientific Reports
Volume	6
DOIs	https://doi.org/10.1038/srep31643
Publication status	Published - 22 Aug 2016

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AU - Been, Jasper V.

AU - de Jonge, Rogier C. J.

AU - Hanff, Lidwien M.

AU - Wijnen, Rene M. H.

AU - Kornelisse, Rene F.

AU - Reiss, Irwin K. M.

AU - Vermeulen, Marijn J.

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Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study

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