TY - JOUR
T1 - Neoantigen Quantity and Quality in Relation to Pancreatic Cancer Survival
AU - Levink, Iris J.M.
AU - Brosens, Lodewijk A.A.
AU - Rensen, Sander S.
AU - Aberle, Merel R.
AU - Olde Damink, Steven S.W.
AU - Cahen, Djuna L.
AU - Buschow, Sonja I.
AU - Fuhler, Gwenny M.
AU - Peppelenbosch, Maikel P.
AU - Bruno, Marco J.
N1 - Publisher Copyright:
Copyright © 2022 Levink, Brosens, Rensen, Aberle, Olde Damink, Cahen, Buschow, Fuhler, Peppelenbosch and Bruno.
PY - 2022/2/9
Y1 - 2022/2/9
N2 - Introduction: Factors underlying antitumor immunity in pancreatic cancer (PC) are poorly understood. We hypothesized that not neoantigen quantity, but quality, is related to immune cell infiltration and survival. Methodology: We performed genomic and transcriptomic profiling of paired normal, tumor tissue of 13 patients with PC with distinct survival times. Additionally, neoantigens prediction and immunological profiling were performed. Results: The proportion of neoantigens with a low similarity-to-self score was higher in short-term survivors (p < 0.0001), while mutational load and burden, similarity-to-known-pathogens, and immunogenicity of neoantigens were not associated with immune cell infiltration or survival. Discussion: No tumor mutational load or neoantigen quantity, but low similarity-to-self score, was associated with immune cell infiltration and survival.
AB - Introduction: Factors underlying antitumor immunity in pancreatic cancer (PC) are poorly understood. We hypothesized that not neoantigen quantity, but quality, is related to immune cell infiltration and survival. Methodology: We performed genomic and transcriptomic profiling of paired normal, tumor tissue of 13 patients with PC with distinct survival times. Additionally, neoantigens prediction and immunological profiling were performed. Results: The proportion of neoantigens with a low similarity-to-self score was higher in short-term survivors (p < 0.0001), while mutational load and burden, similarity-to-known-pathogens, and immunogenicity of neoantigens were not associated with immune cell infiltration or survival. Discussion: No tumor mutational load or neoantigen quantity, but low similarity-to-self score, was associated with immune cell infiltration and survival.
UR - http://www.scopus.com/inward/record.url?scp=85125311243&partnerID=8YFLogxK
U2 - 10.3389/fmed.2021.751110
DO - 10.3389/fmed.2021.751110
M3 - Article
C2 - 35223878
AN - SCOPUS:85125311243
SN - 2296-858X
VL - 8
JO - Frontiers in Medicine
JF - Frontiers in Medicine
M1 - 751110
ER -