Neoantigen Quantity and Quality in Relation to Pancreatic Cancer Survival

Iris J.M. Levink*, Lodewijk A.A. Brosens, Sander S. Rensen, Merel R. Aberle, Steven S.W. Olde Damink, Djuna L. Cahen, Sonja I. Buschow, Gwenny M. Fuhler, Maikel P. Peppelenbosch, Marco J. Bruno

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
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Abstract

Introduction: Factors underlying antitumor immunity in pancreatic cancer (PC) are poorly understood. We hypothesized that not neoantigen quantity, but quality, is related to immune cell infiltration and survival. Methodology: We performed genomic and transcriptomic profiling of paired normal, tumor tissue of 13 patients with PC with distinct survival times. Additionally, neoantigens prediction and immunological profiling were performed. Results: The proportion of neoantigens with a low similarity-to-self score was higher in short-term survivors (p < 0.0001), while mutational load and burden, similarity-to-known-pathogens, and immunogenicity of neoantigens were not associated with immune cell infiltration or survival. Discussion: No tumor mutational load or neoantigen quantity, but low similarity-to-self score, was associated with immune cell infiltration and survival.

Original languageEnglish
Article number751110
JournalFrontiers in Medicine
Volume8
DOIs
Publication statusPublished - 9 Feb 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Levink, Brosens, Rensen, Aberle, Olde Damink, Cahen, Buschow, Fuhler, Peppelenbosch and Bruno.

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