Low prosocial behavior in childhood has been consistently linked to later psychopathology, with evidence supporting the influence of both genetic and environmental factors on its development. Although neonatal DNA methylation (DNAm) has been found to prospectively associate with a range of psychological traits in childhood, its potential role in prosocial development has yet to be investigated. This study investigated prospective associations between cord blood DNAm at birth and low prosocial behavior within and across four longitudinal birth cohorts from the Pregnancy And Childhood Epigenetics (PACE) Consortium. We examined (a) developmental trajectories of “chronic-low” versus “typical” prosocial behavior across childhood in a case–control design (N = 2,095), and (b) continuous “low prosocial” scores at comparable cross-cohort time-points (N = 2,121). Meta-analyses were performed to examine differentially methylated positions and regions. At the cohort-specific level, three CpGs were found to associate with chronic low prosocial behavior; however, none of these associations was replicated in another cohort. Meta-analysis revealed no epigenome-wide significant CpGs or regions. Overall, we found no evidence for associations between DNAm patterns at birth and low prosocial behavior across childhood. Findings highlight the importance of employing multi-cohort approaches to replicate epigenetic associations and reduce the risk of false positive discoveries.
|Number of pages||14|
|Journal||American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics|
|Publication status||Published - 25 Jun 2021|
Bibliographical noteFunding information: Agence Nationale de Securite Sanitaire de l'Alimentation de l'Environnement et du Travail, Grant/Award Number: 1262C0010; Agència de Gestió d'Ajuts Universitaris i de Recerca, Grant/Award Numbers: 2009 SGR 501, 2014 SGR 822; China Scholarship Council, Grant/Award Number: 201706990036; Comissió Interdepartamental de Recerca i Innovació Tecnològica, Grant/Award Number: 1999SGR 00241; Deutsches Krebsforschungszentrum; Economic and Social Research Council, Grant/Award Numbers: ES/J500057/1, ES/R005516/1; Eunice Kennedy Shriver National Institute of Child Health and Human Development, Grant/Award Number: R01HD068437; European Commission, Grant/Award Numbers: 261357, 308333, 603794, 634453; Fundació la Marató de TV3, Grant/Award Number: 090430; H2020 European Research Council, Grant/Award Numbers: 268479, 669249; H2020 Marie Skłodowska-Curie Actions, Grant/Award Numbers: 707404, 848158; Helmholtz-Zentrum für Umweltforschung; Instituto de Salud Carlos III, Grant/Award Numbers: CB06/02/0041, CP13/00054, CP16/00128, CP18/00018, G03/176, PI041436, PI081151, PI12/01890, PI15/00118, PI16/00118, PI16/00261, PI18/00547; Medical Research Council, Grant/Award Number: MC_UU_00011/5; Ministerio de Ciencia e Innovación, Grant/Award Number: FJC2018-036335-I; National University of Ireland; Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Grant/Award Numbers: 024-001-003, 050-060-810; Spanish Ministry of Economy and Competitiveness, Grant/Award Number: SAF2012-32991; Spanish Ministry of Health, Grant/Award Numbers: FIS-FEDER-PI03-1615, FIS-FEDER-PI06/0867, FIS-PI04/1436, FIS-PI08/1151, FIS-PI11/00610
© 2021 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.