Neonatal procedural pain affects state, but not trait anxiety behavior in adult rats

Anne R. de Kort*, Elbert A. Joosten, Jacob Patijn, Dick Tibboel, Nynke J. van den Hoogen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
40 Downloads (Pure)

Abstract

The influence of neonatal experiences upon later-life affective behavior is increasingly recognized, but the reported effects on anxiety are often contradictory. The observed effect may depend upon the type of anxiety (state or trait) affected. The current study aims to investigate whether neonatal repetitive needle pricking alters anxiety behavior in adulthood, by assessing both state and trait anxiety in rats. Sprague–Dawley rat pups received four unilateral needle pricks per day, while controls received four tactile stimuli or were left completely undisturbed during the first postnatal week. Mechanical sensitivity was assessed in the neonatal phase and throughout the development. State anxiety was assessed in the open field test and trait anxiety in the elevated zero maze. The results show that repetitive needle pricking leads to acute mechanical hypersensitivity, but does not affect baseline mechanical sensitivity throughout development. In adulthood, animals previously exposed to neonatal procedural pain (including repetitive handling and removal from litter) showed lower state anxiety but did not differ in trait anxiety, as compared with the undisturbed controls. These findings indicate that early-life procedural pain decreases state but not trait anxiety behavior in later life in a rodent model of repetitive needle pricking.

Original languageEnglish
Article numbere22210
JournalDevelopmental Psychobiology
Volume63
Issue number8
Early online date16 Nov 2021
DOIs
Publication statusPublished - Dec 2021

Bibliographical note

Funding Information:
A. R. d. K. is financially supported by the Pain Knowledge Center from Maastricht and an institutional grant from University Maastricht, School Mental Health and Neuroscience.

Publisher Copyright:
© 2021 The Authors. Developmental Psychobiology published by Wiley Periodicals LLC.

Fingerprint

Dive into the research topics of 'Neonatal procedural pain affects state, but not trait anxiety behavior in adult rats'. Together they form a unique fingerprint.

Cite this