TY - JOUR
T1 - NeonatOx
T2 - A Pumpless Extracorporeal Lung Support for Premature Neonates
AU - Arens, Jutta
AU - Schoberer, Mark
AU - Lohr, Anne
AU - Orlikowsky, Thorsten
AU - Seehase, Matthias
AU - Jellema, Reint K.
AU - Collins, Jennifer J.
AU - Kramer, Boris W.
AU - Schmitz-Rode, Thomas
AU - Steinseifer, Ulrich
PY - 2011/11
Y1 - 2011/11
N2 - Gas exchange in premature neonates is regularly impaired by structural and functional immaturity of the lung. Mechanical ventilation, which is vitally important to sustain oxygenation and CO2 elimination, causes, at the same time, mechanical and inflammatory destruction of lung tissue. To date, extracorporeal oxygenation is not a treatment option, one reason among others being the size of available oxygenators and cannulas. We hypothesized that a substantial improvement in gas exchange can be achieved by maintenance of the fetal cardiopulmonary bypass and interposition of a suitable passively driven (arteriovenous) membrane oxygenator. In close cooperation between engineers and neonatologists, we developed a miniaturized oxygenator and adapted cannulas to be used as a pumpless extracorporeal lung support that is connected to the circulation via cannulation of the umbilical cord vessels. First in vitro and in vivo studies show promising results. We regard this as one step on the way to clinical application of the artificial placenta.
AB - Gas exchange in premature neonates is regularly impaired by structural and functional immaturity of the lung. Mechanical ventilation, which is vitally important to sustain oxygenation and CO2 elimination, causes, at the same time, mechanical and inflammatory destruction of lung tissue. To date, extracorporeal oxygenation is not a treatment option, one reason among others being the size of available oxygenators and cannulas. We hypothesized that a substantial improvement in gas exchange can be achieved by maintenance of the fetal cardiopulmonary bypass and interposition of a suitable passively driven (arteriovenous) membrane oxygenator. In close cooperation between engineers and neonatologists, we developed a miniaturized oxygenator and adapted cannulas to be used as a pumpless extracorporeal lung support that is connected to the circulation via cannulation of the umbilical cord vessels. First in vitro and in vivo studies show promising results. We regard this as one step on the way to clinical application of the artificial placenta.
UR - http://www.scopus.com/inward/record.url?scp=81855183201&partnerID=8YFLogxK
U2 - 10.1111/j.1525-1594.2011.01324.x
DO - 10.1111/j.1525-1594.2011.01324.x
M3 - Article
C2 - 21995519
AN - SCOPUS:81855183201
SN - 0160-564X
VL - 35
SP - 997
EP - 1001
JO - Artificial Organs
JF - Artificial Organs
IS - 11
ER -