Neuroanatomical alterations in people with high and low cannabis dependence

Valentina Lorenzetti; Yann Chye; Chao Suo; Mark Walterfang; Dan I Lubman; Michael Takagi; Sarah Whittle; Antonio Verdejo-Garcia; Janna Cousijn; Christos Pantelis; Marc Seal; Alex Fornito; Murat Yücel; Nadia Solowij

doi:10.1177/0004867419859077

Neuroanatomical alterations in people with high and low cannabis dependence

Valentina Lorenzetti
, Yann Chye
, Chao Suo
, Mark Walterfang
, Dan I Lubman
, Michael Takagi
, Sarah Whittle
, Antonio Verdejo-Garcia
, Janna Cousijn
, Christos Pantelis
, Marc Seal
, Alex Fornito
, Murat Yücel
, Nadia Solowij

Australian Catholic University
Monash University
University of Melbourne
Murdoch Children's Research Institute
University of Wollongong
University of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

OBJECTIVES: We aimed to investigate whether severity of cannabis dependence is associated with the neuroanatomy of key brain regions of the stress and reward brain circuits.

METHODS: To examine dependence-specific regional brain alterations, we compared the volumes of regions relevant to reward and stress, between high-dependence cannabis users (CD+, n = 25), low-dependence cannabis users (CD-, n = 20) and controls (n = 37).

RESULTS: Compared to CD- and/or controls, the CD+ group had lower cerebellar white matter and hippocampal volumes, and deflation of the right hippocampus head and tail.

CONCLUSION: These findings provide initial support for neuroadaptations involving stress and reward circuits that are specific to high-dependence cannabis users.

Original language	English
Pages (from-to)	68-75
Number of pages	8
Journal	Australian and New Zealand Journal of Psychiatry
Volume	54
Issue number	1
DOIs	https://doi.org/10.1177/0004867419859077
Publication status	Published - Jan 2020
Externally published	Yes

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Lorenzetti, V., Chye, Y., Suo, C., Walterfang, M., Lubman, D. I., Takagi, M., Whittle, S., Verdejo-Garcia, A., Cousijn, J., Pantelis, C., Seal, M., Fornito, A., Yücel, M., & Solowij, N. (2020). Neuroanatomical alterations in people with high and low cannabis dependence. Australian and New Zealand Journal of Psychiatry, 54(1), 68-75. https://doi.org/10.1177/0004867419859077

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title = "Neuroanatomical alterations in people with high and low cannabis dependence",

abstract = "OBJECTIVES: We aimed to investigate whether severity of cannabis dependence is associated with the neuroanatomy of key brain regions of the stress and reward brain circuits.METHODS: To examine dependence-specific regional brain alterations, we compared the volumes of regions relevant to reward and stress, between high-dependence cannabis users (CD+, n = 25), low-dependence cannabis users (CD-, n = 20) and controls (n = 37).RESULTS: Compared to CD- and/or controls, the CD+ group had lower cerebellar white matter and hippocampal volumes, and deflation of the right hippocampus head and tail.CONCLUSION: These findings provide initial support for neuroadaptations involving stress and reward circuits that are specific to high-dependence cannabis users.",

author = "Valentina Lorenzetti and Yann Chye and Chao Suo and Mark Walterfang and Lubman, \{Dan I\} and Michael Takagi and Sarah Whittle and Antonio Verdejo-Garcia and Janna Cousijn and Christos Pantelis and Marc Seal and Alex Fornito and Murat Y{\"u}cel and Nadia Solowij",

year = "2020",

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Lorenzetti, V, Chye, Y, Suo, C, Walterfang, M, Lubman, DI, Takagi, M, Whittle, S, Verdejo-Garcia, A, Cousijn, J, Pantelis, C, Seal, M, Fornito, A, Yücel, M & Solowij, N 2020, 'Neuroanatomical alterations in people with high and low cannabis dependence', Australian and New Zealand Journal of Psychiatry, vol. 54, no. 1, pp. 68-75. https://doi.org/10.1177/0004867419859077

TY - JOUR

T1 - Neuroanatomical alterations in people with high and low cannabis dependence

AU - Lorenzetti, Valentina

AU - Chye, Yann

AU - Suo, Chao

AU - Walterfang, Mark

AU - Lubman, Dan I

AU - Takagi, Michael

AU - Whittle, Sarah

AU - Verdejo-Garcia, Antonio

AU - Cousijn, Janna

AU - Pantelis, Christos

AU - Seal, Marc

AU - Fornito, Alex

AU - Yücel, Murat

AU - Solowij, Nadia

PY - 2020/1

Y1 - 2020/1

N2 - OBJECTIVES: We aimed to investigate whether severity of cannabis dependence is associated with the neuroanatomy of key brain regions of the stress and reward brain circuits.METHODS: To examine dependence-specific regional brain alterations, we compared the volumes of regions relevant to reward and stress, between high-dependence cannabis users (CD+, n = 25), low-dependence cannabis users (CD-, n = 20) and controls (n = 37).RESULTS: Compared to CD- and/or controls, the CD+ group had lower cerebellar white matter and hippocampal volumes, and deflation of the right hippocampus head and tail.CONCLUSION: These findings provide initial support for neuroadaptations involving stress and reward circuits that are specific to high-dependence cannabis users.

AB - OBJECTIVES: We aimed to investigate whether severity of cannabis dependence is associated with the neuroanatomy of key brain regions of the stress and reward brain circuits.METHODS: To examine dependence-specific regional brain alterations, we compared the volumes of regions relevant to reward and stress, between high-dependence cannabis users (CD+, n = 25), low-dependence cannabis users (CD-, n = 20) and controls (n = 37).RESULTS: Compared to CD- and/or controls, the CD+ group had lower cerebellar white matter and hippocampal volumes, and deflation of the right hippocampus head and tail.CONCLUSION: These findings provide initial support for neuroadaptations involving stress and reward circuits that are specific to high-dependence cannabis users.

U2 - 10.1177/0004867419859077

DO - 10.1177/0004867419859077

M3 - Article

C2 - 31298035

SN - 0004-8674

VL - 54

SP - 68

EP - 75

JO - Australian and New Zealand Journal of Psychiatry

JF - Australian and New Zealand Journal of Psychiatry

IS - 1

ER -

Neuroanatomical alterations in people with high and low cannabis dependence

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