Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury

Dominique L.G. Van Praag*, Kristien Wouters, the CENTER-TBI Participants and Investigators, Filip Van Den Eede, Lindsay Wilson, Andrew I.R. Maas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)
25 Downloads (Pure)


Introduction: Neurocognitive problems associated with posttraumatic stress disorder (PTSD) can interact with impairment resulting from traumatic brain injury (TBI). Research question: We aimed to identify neurocognitive problems associated with probable PTSD following TBI in a civilian sample. Material and methods: The study is part of the CENTER-TBI project (Collaborative European Neurotrauma Effectiveness Research) that aims to better characterize TBI. For this cross-sectional study, we included patients of all severities aged over 15, and a Glasgow Outcome Score Extended (GOSE) above 3. Participants were assessed at six months post-injury on the PTSD Checklist-5 (PCL-5), the Trail Making Test (TMT), the Rey Auditory Verbal Learning Test (RAVLT) and the Cambridge Neuropsychological Test Automated Battery (CANTAB). Primary analysis was a complete case analysis. Regression analyses were performed to investigate the association between the PCL-5 and cognition. Results: Of the 1134 participants included in the complete case analysis, 13.5% screened positive for PTSD. Probable PTSD was significantly associated with higher TMT-(B-A) (OR ​= ​1.35, 95% CI: 1.14–1.60, p ​< ​.001) and lower RAVLT-delayed recall scores (OR ​= ​0.74, 95% CI: 0.61–0.91, p ​= ​.004) after controlling for age, sex, psychiatric history, baseline Glasgow Coma Scale and education. Discussion and conclusion: Poorer performance on cognitive tests assessing task switching and, to a lesser extent, delayed verbal recall is associated with probable PTSD in civilians who have suffered TBI.

Original languageEnglish
Article number100854
JournalBrain and Spine
Publication statusPublished - 2022

Bibliographical note

The data used in preparation of this manuscript was obtained in the context of CENTER-TBI, a large collaborative research project funded by
the European Union 7th Framework program (EC grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung
(Germany), from OneMind (USA) and from Integra LifeSciences Corporation (USA).

Publisher Copyright: © 2021 The Authors


Dive into the research topics of 'Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury'. Together they form a unique fingerprint.

Cite this