Neurodevelopment in school-aged children after intrauterine exposure to antipsychotics

Lisanne Schrijver; Thalia K Robakis; Astrid M Kamperman; Hilmar Bijma; Adriaan Honig; Inge L van Kamp; Witte J G Hoogendijk; Veerle Bergink; Eline M P Poels

doi:10.1111/acps.13517

Neurodevelopment in school-aged children after intrauterine exposure to antipsychotics

Lisanne Schrijver
, Thalia K Robakis
, Astrid M Kamperman
, Hilmar Bijma
, Adriaan Honig
, Inge L van Kamp
, Witte J G Hoogendijk
, Veerle Bergink
, Eline M P Poels^*

^*Corresponding author for this work

Icahn School of Medicine at Mount Sinai
Leiden University Medical Centre

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Web of Science)

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Abstract

OBJECTIVE: Antipsychotics are increasingly prescribed in pregnancy, yet little is known about potential long-term developmental effects on children. In this study, we investigated the effect of prenatal antipsychotic exposure on neurodevelopmental functioning in school-aged children.

METHODS: We performed a cross-sectional neurodevelopmental assessment of 91 children aged 6-14 years whose mothers had severe mental illness and were either exposed or unexposed to antipsychotic medication during pregnancy. Neurodevelopmental outcomes were assessed using validated neurodevelopmental assessment instruments to examine the child's IQ and global cognitive functioning, and the presence of any psychiatric disorders and/or learning problems in the child was assessed by parental report.

RESULTS: No statistically significant associations were found between antipsychotic exposure during pregnancy and either adverse neurodevelopmental outcomes (IQ, neuropsychological function), likelihood of psychiatric diagnosis, or learning problems based on parental report. Analyses were likely limited in power to detect subtler differences in neurodevelopmental functioning because of small sample size and heterogeneity of the sample.

CONCLUSIONS: In this exploratory cohort study, intrauterine exposure to antipsychotics was not associated with any adverse effect on IQ or neurodevelopmental functioning in a cohort of school-aged children (6-14 years).

Original language	English
Pages (from-to)	43-53
Number of pages	11
Journal	Acta Psychiatrica Scandinavica
Volume	147
Issue number	1
Early online date	4 Nov 2022
DOIs	https://doi.org/10.1111/acps.13517 https://doi.org/10.1111/acps.13517
Publication status	Published - Jan 2023

Bibliographical note

Funding Information:
The authors would like to thank all the children and parents who participated in this study. Additionally, the authors are grateful to Ayuk Bakia, Manal Aziz, Ayse Acar-Aydin and volunteers for the assistance in the data collection.

Publisher Copyright:
© 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.

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Acta Psychiatr Scand - 2022 - Schrijver - Neurodevelopment in school‐aged children after intrauterine exposure toFinal published version, 1.2 MBLicence: CC BY-NC-ND

Cite this

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abstract = "OBJECTIVE: Antipsychotics are increasingly prescribed in pregnancy, yet little is known about potential long-term developmental effects on children. In this study, we investigated the effect of prenatal antipsychotic exposure on neurodevelopmental functioning in school-aged children.METHODS: We performed a cross-sectional neurodevelopmental assessment of 91 children aged 6-14 years whose mothers had severe mental illness and were either exposed or unexposed to antipsychotic medication during pregnancy. Neurodevelopmental outcomes were assessed using validated neurodevelopmental assessment instruments to examine the child's IQ and global cognitive functioning, and the presence of any psychiatric disorders and/or learning problems in the child was assessed by parental report.RESULTS: No statistically significant associations were found between antipsychotic exposure during pregnancy and either adverse neurodevelopmental outcomes (IQ, neuropsychological function), likelihood of psychiatric diagnosis, or learning problems based on parental report. Analyses were likely limited in power to detect subtler differences in neurodevelopmental functioning because of small sample size and heterogeneity of the sample.CONCLUSIONS: In this exploratory cohort study, intrauterine exposure to antipsychotics was not associated with any adverse effect on IQ or neurodevelopmental functioning in a cohort of school-aged children (6-14 years).",

author = "Lisanne Schrijver and Robakis, \{Thalia K\} and Kamperman, \{Astrid M\} and Hilmar Bijma and Adriaan Honig and \{van Kamp\}, \{Inge L\} and Hoogendijk, \{Witte J G\} and Veerle Bergink and Poels, \{Eline M P\}",

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AU - Schrijver, Lisanne

AU - Robakis, Thalia K

AU - Kamperman, Astrid M

AU - Bijma, Hilmar

AU - Honig, Adriaan

AU - van Kamp, Inge L

AU - Hoogendijk, Witte J G

AU - Bergink, Veerle

AU - Poels, Eline M P

N1 - Funding Information: The authors would like to thank all the children and parents who participated in this study. Additionally, the authors are grateful to Ayuk Bakia, Manal Aziz, Ayse Acar-Aydin and volunteers for the assistance in the data collection. Publisher Copyright: © 2022 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.

PY - 2023/1

Y1 - 2023/1

N2 - OBJECTIVE: Antipsychotics are increasingly prescribed in pregnancy, yet little is known about potential long-term developmental effects on children. In this study, we investigated the effect of prenatal antipsychotic exposure on neurodevelopmental functioning in school-aged children.METHODS: We performed a cross-sectional neurodevelopmental assessment of 91 children aged 6-14 years whose mothers had severe mental illness and were either exposed or unexposed to antipsychotic medication during pregnancy. Neurodevelopmental outcomes were assessed using validated neurodevelopmental assessment instruments to examine the child's IQ and global cognitive functioning, and the presence of any psychiatric disorders and/or learning problems in the child was assessed by parental report.RESULTS: No statistically significant associations were found between antipsychotic exposure during pregnancy and either adverse neurodevelopmental outcomes (IQ, neuropsychological function), likelihood of psychiatric diagnosis, or learning problems based on parental report. Analyses were likely limited in power to detect subtler differences in neurodevelopmental functioning because of small sample size and heterogeneity of the sample.CONCLUSIONS: In this exploratory cohort study, intrauterine exposure to antipsychotics was not associated with any adverse effect on IQ or neurodevelopmental functioning in a cohort of school-aged children (6-14 years).

AB - OBJECTIVE: Antipsychotics are increasingly prescribed in pregnancy, yet little is known about potential long-term developmental effects on children. In this study, we investigated the effect of prenatal antipsychotic exposure on neurodevelopmental functioning in school-aged children.METHODS: We performed a cross-sectional neurodevelopmental assessment of 91 children aged 6-14 years whose mothers had severe mental illness and were either exposed or unexposed to antipsychotic medication during pregnancy. Neurodevelopmental outcomes were assessed using validated neurodevelopmental assessment instruments to examine the child's IQ and global cognitive functioning, and the presence of any psychiatric disorders and/or learning problems in the child was assessed by parental report.RESULTS: No statistically significant associations were found between antipsychotic exposure during pregnancy and either adverse neurodevelopmental outcomes (IQ, neuropsychological function), likelihood of psychiatric diagnosis, or learning problems based on parental report. Analyses were likely limited in power to detect subtler differences in neurodevelopmental functioning because of small sample size and heterogeneity of the sample.CONCLUSIONS: In this exploratory cohort study, intrauterine exposure to antipsychotics was not associated with any adverse effect on IQ or neurodevelopmental functioning in a cohort of school-aged children (6-14 years).

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Neurodevelopment in school-aged children after intrauterine exposure to antipsychotics

Abstract

Bibliographical note

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