Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data

Erin W Dickie; Stephanie H Ameis; TAY Cohort Study Team; Isabelle Boileau; Andreea O Diaconescu; Daniel Felsky; Benjamin I Goldstein; Vanessa Gonçalves; John D Griffiths; John D Haltigan; Muhammad O Husain; Dafna S Rubin-Kahana; Myera Iftikhar; Melanie Jani; Meng-Chuan Lai; Hsiang-Yuan Lin; Bradley J MacIntosh; Anne L Wheeler; Neil Vasdev; Erica Vieira; Ghazaleh Ahmadzadeh; Lindsay Heyland; Akshay Mohan; Feyi Ogunsanya; Lindsay D Oliver; Cherrie Zhu; Jimmy K Y Wong; Colleen Charlton; Jennifer Truong; Lujia Yu; Rachel Kelly; Kristin Cleverley; Darren B Courtney; George Foussias; Lisa D Hawke; Sean Hill; Nicole Kozloff; Alexia Polillo; Martin Rotenberg; Lena C Quilty; Wanda Tempelaar; Wei Wang; Yuliya S Nikolova; Aristotle N Voineskos

doi:10.1016/j.bpsc.2023.10.013

Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data

Erin W Dickie, Stephanie H Ameis, TAY Cohort Study Team, Isabelle Boileau, Andreea O Diaconescu, Daniel Felsky, Benjamin I Goldstein, Vanessa Gonçalves, John D Griffiths, John D Haltigan, Muhammad O Husain, Dafna S Rubin-Kahana, Myera Iftikhar, Melanie Jani, Meng-Chuan Lai, Hsiang-Yuan Lin, Bradley J MacIntosh, Anne L Wheeler, Neil Vasdev, Erica VieiraGhazaleh Ahmadzadeh, Lindsay Heyland, Akshay Mohan, Feyi Ogunsanya, Lindsay D Oliver, Cherrie Zhu, Jimmy K Y Wong, Colleen Charlton, Jennifer Truong, Lujia Yu, Rachel Kelly, Kristin Cleverley, Darren B Courtney, George Foussias, Lisa D Hawke, Sean Hill, Nicole Kozloff, Alexia Polillo, Martin Rotenberg, Lena C Quilty, Wanda Tempelaar, Wei Wang, Yuliya S Nikolova, Aristotle N Voineskos^*

^*Corresponding author for this work

Department of Technology and Operations Management

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND:

The Toronto Adolescent and Youth (TAY) Cohort Study will characterize the neurobiological trajectories of psychosis spectrum symptoms, functioning, and suicidality (i.e., suicidal thoughts and behaviors) in youth seeking mental health care. Here, we present the neuroimaging and biosample component of the protocol. We also present feasibility and quality control metrics for the baseline sample collected thus far.

METHODS:

The current study includes youths (ages 11-24 years) who were referred to child and youth mental health services within a large tertiary care center in Toronto, Ontario, Canada, with target recruitment of 1500 participants. Participants were offered the opportunity to provide any or all of the following: 1) 1-hour magnetic resonance imaging (MRI) scan (electroencephalography if ineligible for or declined MRI), 2) blood sample for genomic and proteomic data (or saliva if blood collection was declined or not feasible) and urine sample, and 3) heart rate recording to assess respiratory sinus arrhythmia.

RESULTS:

Of the first 417 participants who consented to participate between May 4, 2021, and February 2, 2023, 412 agreed to participate in the imaging and biosample protocol. Of these, 334 completed imaging, 341 provided a biosample, 338 completed respiratory sinus arrhythmia, and 316 completed all 3. Following quality control, data usability was high (MRI: T1-weighted 99%, diffusion-weighted imaging 99%, arterial spin labeling 90%, resting-state functional MRI 95%, task functional MRI 90%; electroencephalography: 83%; respiratory sinus arrhythmia: 99%).

CONCLUSIONS:

The high consent rates, good completion rates, and high data usability reported here demonstrate the feasibility of collecting and using brain imaging and biosamples in a large clinical cohort of youths seeking mental health care.

Original language	English
Pages (from-to)	275-284
Number of pages	10
Journal	Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/j.bpsc.2023.10.013
Publication status	Published - Mar 2024

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Publisher Copyright:
© 2023 Society of Biological Psychiatry

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Dickie, E. W., Ameis, S. H., TAY Cohort Study Team, Boileau, I., Diaconescu, A. O., Felsky, D., Goldstein, B. I., Gonçalves, V., Griffiths, J. D., Haltigan, J. D., Husain, M. O., Rubin-Kahana, D. S., Iftikhar, M., Jani, M., Lai, M.-C., Lin, H.-Y., MacIntosh, B. J., Wheeler, A. L., Vasdev, N., ... Voineskos, A. N. (2024). Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(3), 275-284. https://doi.org/10.1016/j.bpsc.2023.10.013

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title = "Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data",

abstract = "BACKGROUND: The Toronto Adolescent and Youth (TAY) Cohort Study will characterize the neurobiological trajectories of psychosis spectrum symptoms, functioning, and suicidality (i.e., suicidal thoughts and behaviors) in youth seeking mental health care. Here, we present the neuroimaging and biosample component of the protocol. We also present feasibility and quality control metrics for the baseline sample collected thus far.METHODS: The current study includes youths (ages 11-24 years) who were referred to child and youth mental health services within a large tertiary care center in Toronto, Ontario, Canada, with target recruitment of 1500 participants. Participants were offered the opportunity to provide any or all of the following: 1) 1-hour magnetic resonance imaging (MRI) scan (electroencephalography if ineligible for or declined MRI), 2) blood sample for genomic and proteomic data (or saliva if blood collection was declined or not feasible) and urine sample, and 3) heart rate recording to assess respiratory sinus arrhythmia.RESULTS: Of the first 417 participants who consented to participate between May 4, 2021, and February 2, 2023, 412 agreed to participate in the imaging and biosample protocol. Of these, 334 completed imaging, 341 provided a biosample, 338 completed respiratory sinus arrhythmia, and 316 completed all 3. Following quality control, data usability was high (MRI: T1-weighted 99%, diffusion-weighted imaging 99%, arterial spin labeling 90%, resting-state functional MRI 95%, task functional MRI 90%; electroencephalography: 83%; respiratory sinus arrhythmia: 99%).CONCLUSIONS: The high consent rates, good completion rates, and high data usability reported here demonstrate the feasibility of collecting and using brain imaging and biosamples in a large clinical cohort of youths seeking mental health care.",

author = "Dickie, {Erin W} and Ameis, {Stephanie H} and {TAY Cohort Study Team} and Isabelle Boileau and Diaconescu, {Andreea O} and Daniel Felsky and Goldstein, {Benjamin I} and Vanessa Gon{\c c}alves and Griffiths, {John D} and Haltigan, {John D} and Husain, {Muhammad O} and Rubin-Kahana, {Dafna S} and Myera Iftikhar and Melanie Jani and Meng-Chuan Lai and Hsiang-Yuan Lin and MacIntosh, {Bradley J} and Wheeler, {Anne L} and Neil Vasdev and Erica Vieira and Ghazaleh Ahmadzadeh and Lindsay Heyland and Akshay Mohan and Feyi Ogunsanya and Oliver, {Lindsay D} and Cherrie Zhu and Wong, {Jimmy K Y} and Colleen Charlton and Jennifer Truong and Lujia Yu and Rachel Kelly and Kristin Cleverley and Courtney, {Darren B} and George Foussias and Hawke, {Lisa D} and Sean Hill and Nicole Kozloff and Alexia Polillo and Martin Rotenberg and Quilty, {Lena C} and Wanda Tempelaar and Wei Wang and Nikolova, {Yuliya S} and Voineskos, {Aristotle N}",

note = "Publisher Copyright: {\textcopyright} 2023 Society of Biological Psychiatry",

year = "2024",

month = mar,

doi = "10.1016/j.bpsc.2023.10.013",

language = "English",

volume = "9",

pages = "275--284",

journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",

issn = "2451-9022",

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Dickie, EW, Ameis, SH, TAY Cohort Study Team, Boileau, I, Diaconescu, AO, Felsky, D, Goldstein, BI, Gonçalves, V, Griffiths, JD, Haltigan, JD, Husain, MO, Rubin-Kahana, DS, Iftikhar, M, Jani, M, Lai, M-C, Lin, H-Y, MacIntosh, BJ, Wheeler, AL, Vasdev, N, Vieira, E, Ahmadzadeh, G, Heyland, L, Mohan, A, Ogunsanya, F, Oliver, LD, Zhu, C, Wong, JKY, Charlton, C, Truong, J, Yu, L, Kelly, R, Cleverley, K, Courtney, DB, Foussias, G, Hawke, LD, Hill, S, Kozloff, N, Polillo, A, Rotenberg, M, Quilty, LC, Tempelaar, W , Wang, W, Nikolova, YS & Voineskos, AN 2024, 'Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 9, no. 3, pp. 275-284. https://doi.org/10.1016/j.bpsc.2023.10.013

Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data. / Dickie, Erin W; Ameis, Stephanie H; TAY Cohort Study Team et al.
In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 9, No. 3, 03.2024, p. 275-284.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study

T2 - Rationale, Methods, and Early Data

AU - Dickie, Erin W

AU - Ameis, Stephanie H

AU - TAY Cohort Study Team

AU - Boileau, Isabelle

AU - Diaconescu, Andreea O

AU - Felsky, Daniel

AU - Goldstein, Benjamin I

AU - Gonçalves, Vanessa

AU - Griffiths, John D

AU - Haltigan, John D

AU - Husain, Muhammad O

AU - Rubin-Kahana, Dafna S

AU - Iftikhar, Myera

AU - Jani, Melanie

AU - Lai, Meng-Chuan

AU - Lin, Hsiang-Yuan

AU - MacIntosh, Bradley J

AU - Wheeler, Anne L

AU - Vasdev, Neil

AU - Vieira, Erica

AU - Ahmadzadeh, Ghazaleh

AU - Heyland, Lindsay

AU - Mohan, Akshay

AU - Ogunsanya, Feyi

AU - Oliver, Lindsay D

AU - Zhu, Cherrie

AU - Wong, Jimmy K Y

AU - Charlton, Colleen

AU - Truong, Jennifer

AU - Yu, Lujia

AU - Kelly, Rachel

AU - Cleverley, Kristin

AU - Courtney, Darren B

AU - Foussias, George

AU - Hawke, Lisa D

AU - Hill, Sean

AU - Kozloff, Nicole

AU - Polillo, Alexia

AU - Rotenberg, Martin

AU - Quilty, Lena C

AU - Tempelaar, Wanda

AU - Wang, Wei

AU - Nikolova, Yuliya S

AU - Voineskos, Aristotle N

PY - 2024/3

Y1 - 2024/3

N2 - BACKGROUND: The Toronto Adolescent and Youth (TAY) Cohort Study will characterize the neurobiological trajectories of psychosis spectrum symptoms, functioning, and suicidality (i.e., suicidal thoughts and behaviors) in youth seeking mental health care. Here, we present the neuroimaging and biosample component of the protocol. We also present feasibility and quality control metrics for the baseline sample collected thus far.METHODS: The current study includes youths (ages 11-24 years) who were referred to child and youth mental health services within a large tertiary care center in Toronto, Ontario, Canada, with target recruitment of 1500 participants. Participants were offered the opportunity to provide any or all of the following: 1) 1-hour magnetic resonance imaging (MRI) scan (electroencephalography if ineligible for or declined MRI), 2) blood sample for genomic and proteomic data (or saliva if blood collection was declined or not feasible) and urine sample, and 3) heart rate recording to assess respiratory sinus arrhythmia.RESULTS: Of the first 417 participants who consented to participate between May 4, 2021, and February 2, 2023, 412 agreed to participate in the imaging and biosample protocol. Of these, 334 completed imaging, 341 provided a biosample, 338 completed respiratory sinus arrhythmia, and 316 completed all 3. Following quality control, data usability was high (MRI: T1-weighted 99%, diffusion-weighted imaging 99%, arterial spin labeling 90%, resting-state functional MRI 95%, task functional MRI 90%; electroencephalography: 83%; respiratory sinus arrhythmia: 99%).CONCLUSIONS: The high consent rates, good completion rates, and high data usability reported here demonstrate the feasibility of collecting and using brain imaging and biosamples in a large clinical cohort of youths seeking mental health care.

AB - BACKGROUND: The Toronto Adolescent and Youth (TAY) Cohort Study will characterize the neurobiological trajectories of psychosis spectrum symptoms, functioning, and suicidality (i.e., suicidal thoughts and behaviors) in youth seeking mental health care. Here, we present the neuroimaging and biosample component of the protocol. We also present feasibility and quality control metrics for the baseline sample collected thus far.METHODS: The current study includes youths (ages 11-24 years) who were referred to child and youth mental health services within a large tertiary care center in Toronto, Ontario, Canada, with target recruitment of 1500 participants. Participants were offered the opportunity to provide any or all of the following: 1) 1-hour magnetic resonance imaging (MRI) scan (electroencephalography if ineligible for or declined MRI), 2) blood sample for genomic and proteomic data (or saliva if blood collection was declined or not feasible) and urine sample, and 3) heart rate recording to assess respiratory sinus arrhythmia.RESULTS: Of the first 417 participants who consented to participate between May 4, 2021, and February 2, 2023, 412 agreed to participate in the imaging and biosample protocol. Of these, 334 completed imaging, 341 provided a biosample, 338 completed respiratory sinus arrhythmia, and 316 completed all 3. Following quality control, data usability was high (MRI: T1-weighted 99%, diffusion-weighted imaging 99%, arterial spin labeling 90%, resting-state functional MRI 95%, task functional MRI 90%; electroencephalography: 83%; respiratory sinus arrhythmia: 99%).CONCLUSIONS: The high consent rates, good completion rates, and high data usability reported here demonstrate the feasibility of collecting and using brain imaging and biosamples in a large clinical cohort of youths seeking mental health care.

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U2 - 10.1016/j.bpsc.2023.10.013

DO - 10.1016/j.bpsc.2023.10.013

M3 - Article

C2 - 37979944

SN - 2451-9022

VL - 9

SP - 275

EP - 284

JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

IS - 3

ER -

Neuroimaging and Biosample Collection in the Toronto Adolescent and Youth Cohort Study: Rationale, Methods, and Early Data

Abstract

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