Neuroimmunological regulation of a-MSH release in tilapia (Oreochromis mossambicus)

Esther M.M. Van Lieshout; P. H. M.  Balm; P. Pepels; S.E. Wendelaar Bonga

doi:10.1007/BF00004558

Neuroimmunological regulation of a-MSH release in tilapia (Oreochromis mossambicus)

Esther M.M. Van Lieshout, P. H. M. Balm, P. Pepels, S.E. Wendelaar Bonga

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Abstract

This study describes the effects of IL-1 (interleukin 1) and LPS (bacterial endotoxin lipopolysaccharide) on the release of α-MSH (alpha melanocyte stimulating hormone) from the neurointermediate lobe (NIL) of the teleost Oreochromis mossambicus (tilapia). In vivo treatment of tilapia with IL-1 for 8 days led to a 49% inhibition of basal α-MSH release, measured by means of an in vitro micro-superfusion technique. The treatment did not affect the sensitivity of the tissue to TRH. In vitro, the release of α-MSH was inhibited by LPS in a dose dependent manner. In addition to its effects on the unstimulated release of the hormone, LPS also blunted the response to a TRH stimulation. Together with recent results obtained by others demonstrating the effects of (neuro-)peptides on immune parameters and the presence of cytokines in fish, the present data establish the bidirectional character of the communication between the immune and the (neuro-)endocrine systems in teleosts.

Original language	English
Pages (from-to)	125–130
Journal	Fish Physiology and Biochemistry
Volume	11
DOIs	https://doi.org/10.1007/BF00004558
Publication status	Published - Jul 1993
Externally published	Yes

Bibliographical note

Acknowledgements
The authors would like to thank Jolanda Lokate
for doing part of the experimental work. This work
has been grant aided by the Netherlands Organization for Scientific Research (NWO).

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@article{430061b9e99c45f8a1fd2283a633a2b9,

title = "Neuroimmunological regulation of a-MSH release in tilapia (Oreochromis mossambicus)",

abstract = "This study describes the effects of IL-1 (interleukin 1) and LPS (bacterial endotoxin lipopolysaccharide) on the release of α-MSH (alpha melanocyte stimulating hormone) from the neurointermediate lobe (NIL) of the teleost Oreochromis mossambicus (tilapia). In vivo treatment of tilapia with IL-1 for 8 days led to a 49% inhibition of basal α-MSH release, measured by means of an in vitro micro-superfusion technique. The treatment did not affect the sensitivity of the tissue to TRH. In vitro, the release of α-MSH was inhibited by LPS in a dose dependent manner. In addition to its effects on the unstimulated release of the hormone, LPS also blunted the response to a TRH stimulation. Together with recent results obtained by others demonstrating the effects of (neuro-)peptides on immune parameters and the presence of cytokines in fish, the present data establish the bidirectional character of the communication between the immune and the (neuro-)endocrine systems in teleosts.",

author = "{Van Lieshout}, {Esther M.M.} and Balm, {P. H. M.} and P. Pepels and {Wendelaar Bonga}, S.E.",

note = "Acknowledgements The authors would like to thank Jolanda Lokate for doing part of the experimental work. This work has been grant aided by the Netherlands Organization for Scientific Research (NWO).",

year = "1993",

month = jul,

doi = "10.1007/BF00004558",

language = "English",

volume = "11",

pages = "125–130",

journal = "Fish Physiology and Biochemistry",

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T1 - Neuroimmunological regulation of a-MSH release in tilapia (Oreochromis mossambicus)

AU - Van Lieshout, Esther M.M.

AU - Balm, P. H. M.

AU - Pepels, P.

AU - Wendelaar Bonga, S.E.

N1 - Acknowledgements The authors would like to thank Jolanda Lokate for doing part of the experimental work. This work has been grant aided by the Netherlands Organization for Scientific Research (NWO).

PY - 1993/7

Y1 - 1993/7

N2 - This study describes the effects of IL-1 (interleukin 1) and LPS (bacterial endotoxin lipopolysaccharide) on the release of α-MSH (alpha melanocyte stimulating hormone) from the neurointermediate lobe (NIL) of the teleost Oreochromis mossambicus (tilapia). In vivo treatment of tilapia with IL-1 for 8 days led to a 49% inhibition of basal α-MSH release, measured by means of an in vitro micro-superfusion technique. The treatment did not affect the sensitivity of the tissue to TRH. In vitro, the release of α-MSH was inhibited by LPS in a dose dependent manner. In addition to its effects on the unstimulated release of the hormone, LPS also blunted the response to a TRH stimulation. Together with recent results obtained by others demonstrating the effects of (neuro-)peptides on immune parameters and the presence of cytokines in fish, the present data establish the bidirectional character of the communication between the immune and the (neuro-)endocrine systems in teleosts.

AB - This study describes the effects of IL-1 (interleukin 1) and LPS (bacterial endotoxin lipopolysaccharide) on the release of α-MSH (alpha melanocyte stimulating hormone) from the neurointermediate lobe (NIL) of the teleost Oreochromis mossambicus (tilapia). In vivo treatment of tilapia with IL-1 for 8 days led to a 49% inhibition of basal α-MSH release, measured by means of an in vitro micro-superfusion technique. The treatment did not affect the sensitivity of the tissue to TRH. In vitro, the release of α-MSH was inhibited by LPS in a dose dependent manner. In addition to its effects on the unstimulated release of the hormone, LPS also blunted the response to a TRH stimulation. Together with recent results obtained by others demonstrating the effects of (neuro-)peptides on immune parameters and the presence of cytokines in fish, the present data establish the bidirectional character of the communication between the immune and the (neuro-)endocrine systems in teleosts.

U2 - 10.1007/BF00004558

DO - 10.1007/BF00004558

M3 - Article

VL - 11

SP - 125

EP - 130

JO - Fish Physiology and Biochemistry

JF - Fish Physiology and Biochemistry

SN - 0920-1742

ER -

Neuroimmunological regulation of a-MSH release in tilapia (Oreochromis mossambicus)

Abstract

Bibliographical note

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