New applications of cholangiocarcinoma organoids: modelling the tumor immune and extracellular microenvironment

Ruby Lieshout

New applications of cholangiocarcinoma organoids: modelling the tumor immune and extracellular microenvironment

Ruby Lieshout

Surgery

Research output: Types of Thesis › Doctoral Thesis › Internal

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Abstract

This thesis describes new applications of the CCA organoid model, in which the model is expanded with the immune and extracellular tumor microenvironment components, the CCA organoid kinome is explored, and the influence of pro-inflammatory cytokines is examined. This demonstrates that CCA organoids, in their current form or supplemented with tumor microenvironment components, are a promising model for the discovery of new therapies and tumor stratification strategies.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	van der Laan, Luc, Supervisor IJzermans, Jan N.M., Supervisor Verstegen, Monique, Co-supervisor
Award date	14 Dec 2022
Print ISBNs	978‐94‐6469‐125‐2
Publication status	Published - 14 Dec 2022

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title = "New applications of cholangiocarcinoma organoids: modelling the tumor immune and extracellular microenvironment",

abstract = "This thesis describes new applications of the CCA organoid model, in which the model is expanded with the immune and extracellular tumor microenvironment components, the CCA organoid kinome is explored, and the influence of pro-inflammatory cytokines is examined. This demonstrates that CCA organoids, in their current form or supplemented with tumor microenvironment components, are a promising model for the discovery of new therapies and tumor stratification strategies.",

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N2 - This thesis describes new applications of the CCA organoid model, in which the model is expanded with the immune and extracellular tumor microenvironment components, the CCA organoid kinome is explored, and the influence of pro-inflammatory cytokines is examined. This demonstrates that CCA organoids, in their current form or supplemented with tumor microenvironment components, are a promising model for the discovery of new therapies and tumor stratification strategies.

AB - This thesis describes new applications of the CCA organoid model, in which the model is expanded with the immune and extracellular tumor microenvironment components, the CCA organoid kinome is explored, and the influence of pro-inflammatory cytokines is examined. This demonstrates that CCA organoids, in their current form or supplemented with tumor microenvironment components, are a promising model for the discovery of new therapies and tumor stratification strategies.

M3 - Doctoral Thesis

SN - 978‐94‐6469‐125‐2

ER -

New applications of cholangiocarcinoma organoids: modelling the tumor immune and extracellular microenvironment

Abstract

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