New Aspects of Kidney Fibrosis–From Mechanisms of Injury to Modulation of Disease

Marcus J. Moeller, Rafael Kramann, Twan Lammers, Bernd Hoppe, Eicke Latz, Isis Ludwig-Portugall, Peter Boor, Jürgen Floege, Christian Kurts, Ralf Weiskirchen, Tammo Ostendorf*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

25 Citations (Scopus)
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Abstract

Organ fibrogenesis is characterized by a common pathophysiological final pathway independent of the underlying progressive disease of the respective organ. This makes it particularly suitable as a therapeutic target. The Transregional Collaborative Research Center “Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease” (referred to as SFB/TRR57) was hosted from 2009 to 2021 by the Medical Faculties of RWTH Aachen University and the University of Bonn. This consortium had the ultimate goal of discovering new common but also different fibrosis pathways in the liver and kidneys. It finally successfully identified new mechanisms and established novel therapeutic approaches to interfere with hepatic and renal fibrosis. This review covers the consortium's key kidney-related findings, where three overarching questions were addressed: (i) What are new relevant mechanisms and signaling pathways triggering renal fibrosis? (ii) What are new immunological mechanisms, cells and molecules that contribute to renal fibrosis?, and finally (iii) How can renal fibrosis be modulated?

Original languageEnglish
Article number814497
JournalFrontiers in Medicine
Volume8
DOIs
Publication statusPublished - 12 Jan 2022

Bibliographical note

Funding Information:
The Collaborative Research Center SFB/TRR57 “Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease” was funded by the DFG for 13 years from 2009 to 2021. The aim was to face the challenge of liver and kidney fibrosis. The overarching subject areas of the SFB/TRR57 were (i) initiation of fibrosis, (ii) immunological mechanisms and (iii) repair and modulation of fibrosis. This overview specifically summarizes key research results of the consortium concerning kidney fibrosis. We are aware that there are many further important pathways leading to kidney fibrosis that have now been confirmed and established in many studies worldwide. These include, for example, the signaling pathways of numerous growth factors and cytokines, complex pathways controlled by long non-coding RNA or metalloproteinases and many others that we cannot deal with in this review and for which we would like to refer to excellent recent reviews (2, 4–8).

Publisher Copyright:
Copyright © 2022 Moeller, Kramann, Lammers, Hoppe, Latz, Ludwig-Portugall, Boor, Floege, Kurts, Weiskirchen and Ostendorf.

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