New concepts in the design of drug-eluting coronary stents

Scot Garg, Fatma Bektas, PWJC (Patrick) Serruys

Research output: Contribution to journalArticleAcademicpeer-review

113 Citations (Scopus)

Abstract

Drug-eluting stents (DES) have revolutionized the practice of interventional cardiology over the past decade. Although their efficacy has never been called into question, concerns have been raised regarding their safety, particularly with respect to very late stent thrombosis. These valid concerns have prompted extensive research into improving stent safety, with particular interest in modifying the permanent polymer used on first-generation DES. Subsequently, various new types of coronary stent have been developed, including DES with biocompatible polymers, DES with biodegradable polymers, polymer-free DES, and completely bioresorbable scaffolds. Some of these new DES are already available in clinical practice, and others are currently undergoing clinical evaluation. Improvements in stent performance have made detecting statistically robust and clinically relevant differences between contemporary devices difficult. The wide array of available stents enables the choice of device to be tailored to the individual patient. Garg, S. et al. Nat. Rev. Cardiol. 10, 248-260 (2013); published online 19 February 2013; doi: 10.1038/nrcardio.2013.13
Original languageUndefined/Unknown
Pages (from-to)248-260
Number of pages13
JournalNature Reviews Cardiology
Volume10
Issue number5
DOIs
Publication statusPublished - 2013

Research programs

  • EMC COEUR-09

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