TY - JOUR
T1 - New diagnostic approach of the different types of isolated craniosynostosis
AU - Kronig, Sophia A.J.
AU - Kronig, Otto D.M.
AU - Vrooman, Henri A.
AU - Veenland, Jifke F.
AU - Van Adrichem, Léon N.A.
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2021/4
Y1 - 2021/4
N2 - In this study, we diagnose skull shape deformities by analysing sinusoid curves obtained from standardized computed tomography (CT) slices of the skull for the common craniosynostoses (scaphocephaly, brachycephaly, trigonocephaly, right- and left-sided anterior plagiocephaly). Scaphocephaly has a high forehead peak and low troughs, in contrast to brachycephaly. Anterior plagiocephaly has asymmetry and shifting of the forehead peak. Trigonocephaly has a high and narrow frontal peak. Control patients have a symmetrical skull shape with low troughs and a high and broader frontal peak. Firstly, we included 5 children of every group of the common craniosynostoses and additionally 5 controls for extraction and calculation of characteristics. A diagnostic flowchart was developed. Secondly, we included a total of 51 craniosynostosis patients to validate the flowchart. All patients were correctly classified using the flowchart. Conclusion: Our study proposes and implements a new diagnostic approach of craniosynostosis. We describe a diagnostic flowchart based on specific characteristics for every type of craniosynostosis related to the specific skull deformities and control patients. All variables are expressed in number; therefore, we are able to use these variables in future research to quantify the different types of craniosynostosis.What is Known:• Premature fusion of one or more cranial sutures results in a specific cranial shape.• Clinical diagnosis is relatively simple; however, objective diagnosis based on distinctive values is difficult.What is New:• Using external landmarks and curve analysis, distinctive variables, and values for every type of craniosynostosis related to the specific skull deformities were determined and used to create a diagnostic flowchart for diagnosis.• Validation with an independent data set of 51 patients showed that all patients were correctly classified.
AB - In this study, we diagnose skull shape deformities by analysing sinusoid curves obtained from standardized computed tomography (CT) slices of the skull for the common craniosynostoses (scaphocephaly, brachycephaly, trigonocephaly, right- and left-sided anterior plagiocephaly). Scaphocephaly has a high forehead peak and low troughs, in contrast to brachycephaly. Anterior plagiocephaly has asymmetry and shifting of the forehead peak. Trigonocephaly has a high and narrow frontal peak. Control patients have a symmetrical skull shape with low troughs and a high and broader frontal peak. Firstly, we included 5 children of every group of the common craniosynostoses and additionally 5 controls for extraction and calculation of characteristics. A diagnostic flowchart was developed. Secondly, we included a total of 51 craniosynostosis patients to validate the flowchart. All patients were correctly classified using the flowchart. Conclusion: Our study proposes and implements a new diagnostic approach of craniosynostosis. We describe a diagnostic flowchart based on specific characteristics for every type of craniosynostosis related to the specific skull deformities and control patients. All variables are expressed in number; therefore, we are able to use these variables in future research to quantify the different types of craniosynostosis.What is Known:• Premature fusion of one or more cranial sutures results in a specific cranial shape.• Clinical diagnosis is relatively simple; however, objective diagnosis based on distinctive values is difficult.What is New:• Using external landmarks and curve analysis, distinctive variables, and values for every type of craniosynostosis related to the specific skull deformities were determined and used to create a diagnostic flowchart for diagnosis.• Validation with an independent data set of 51 patients showed that all patients were correctly classified.
UR - http://www.scopus.com/inward/record.url?scp=85095121523&partnerID=8YFLogxK
U2 - 10.1007/s00431-020-03860-9
DO - 10.1007/s00431-020-03860-9
M3 - Article
C2 - 33151409
AN - SCOPUS:85095121523
SN - 0340-6199
VL - 180
SP - 1211
EP - 1217
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 4
ER -