New loci associated with kidney function and chronic kidney disease

A Kottgen; C Pattaro; CA Boger; C Fuchsberger; M Olden; NL Glazer; A Parsa; XY Gao; Q Yang; AV Smith; JR O'Connell; M Li; Heléna Schmidt; T Tanaka; Aaron Isaacs; S Ketkar; SJ Hwang; AD Johnson; Abbas Dehghan; A Teumer; G Pare; EJ Atkinson; T Zeller; K Lohman; MC Cornelis; NM Probst-Hensch; F Kronenberg; A Tonjes; C Hayward; T Aspelund; G Eiriksdottir; LJ (Lenore) Launer; TB Harris; E Rampersaud; BD Mitchell; DE Arking; E Boerwinkle; Maksim Struchalin; M Cavalieri; A Singleton; F Giallauria; J Metter; IH (Ian) Boer; T Haritunians; T Lumley; D Siscovick; BM Psaty; M.C. Zillikens; Ben Oostra; M Feitosa; M Province; M de Andrade; ST Turner; A Schillert; A Ziegler; PS Wild; RB Schnabel; S Wilde; T Munzel; TS Leak; T Illig; N Klopp; C Meisinger; HE Wichmann; W Koenig; L Zgaga; T Zemunik; I Kolcic; C Minelli; FB Hu; A Johansson; W Igl; G Zaboli; SH Wild; AF Wright; H Campbell; D Ellinghaus; S Schreiber; YS Aulchenko; Janine Felix; Fernando Rivadeneira; André Uitterlinden; Bert Hofman; M Imboden; D Nitsch; A Brandstatter; B Kollerits; L Kedenko; R Magi; M Stumvoll; P Kovacs; M Boban; S Campbell; K Endlich; H Volzke; HK Kroemer; M Nauck; U Volker; O Polasek; V Vitart; S Badola; AN Parker; PM Ridker; SLR Kardia; S Blankenberg; YM Liu; GC Curhan; A Franke; T Rochat; B Paulweber; I Prokopenko; W (Wei) Wang; V Gudnason; AR Shuldiner; J Coresh; R Schmidt; L Ferrucci; MG Shlipak; Cornelia Duijn; I Borecki; BK Kramer; I Rudan; U Gyllensten; JF Wilson; JCM Witteman; PP Pramstaller; R Rettig; N Hastie; DI Chasman; WH Kao; IM Heid; CS Fox

doi:10.1038/ng.568

New loci associated with kidney function and chronic kidney disease

A Kottgen, C Pattaro, CA Boger, C Fuchsberger, M Olden, NL Glazer, A Parsa, XY Gao, Q Yang, AV Smith, JR O'Connell, M Li, Heléna Schmidt, T Tanaka, Aaron Isaacs, S Ketkar, SJ Hwang, AD Johnson, Abbas Dehghan, A TeumerG Pare, EJ Atkinson, T Zeller, K Lohman, MC Cornelis, NM Probst-Hensch, F Kronenberg, A Tonjes, C Hayward, T Aspelund, G Eiriksdottir, LJ (Lenore) Launer, TB Harris, E Rampersaud, BD Mitchell, DE Arking, E Boerwinkle, Maksim Struchalin, M Cavalieri, A Singleton, F Giallauria, J Metter, IH (Ian) Boer, T Haritunians, T Lumley, D Siscovick, BM Psaty, M.C. Zillikens, Ben Oostra, M Feitosa, M Province, M de Andrade, ST Turner, A Schillert, A Ziegler, PS Wild, RB Schnabel, S Wilde, T Munzel, TS Leak, T Illig, N Klopp, C Meisinger, HE Wichmann, W Koenig, L Zgaga, T Zemunik, I Kolcic, C Minelli, FB Hu, A Johansson, W Igl, G Zaboli, SH Wild, AF Wright, H Campbell, D Ellinghaus, S Schreiber, YS Aulchenko, Janine Felix, Fernando Rivadeneira, André Uitterlinden, Bert Hofman, M Imboden, D Nitsch, A Brandstatter, B Kollerits, L Kedenko, R Magi, M Stumvoll, P Kovacs, M Boban, S Campbell, K Endlich, H Volzke, HK Kroemer, M Nauck, U Volker, O Polasek, V Vitart, S Badola, AN Parker, PM Ridker, SLR Kardia, S Blankenberg, YM Liu, GC Curhan, A Franke, T Rochat, B Paulweber, I Prokopenko, W (Wei) Wang, V Gudnason, AR Shuldiner, J Coresh, R Schmidt, L Ferrucci, MG Shlipak, Cornelia Duijn, I Borecki, BK Kramer, I Rudan, U Gyllensten, JF Wilson, JCM Witteman, PP Pramstaller, R Rettig, N Hastie, DI Chasman, WH Kao, IM Heid, CS Fox

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creat-inine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/ 1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

Original language	Undefined/Unknown
Pages (from-to)	376-U34
Journal	Nature Genetics
Volume	42
Issue number	5
DOIs	https://doi.org/10.1038/ng.568
Publication status	Published - 2010

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EMC MM-01-39-02

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.568

http://hdl.handle.net/1765/19755

Cite this

Kottgen, A., Pattaro, C., Boger, CA., Fuchsberger, C., Olden, M., Glazer, NL., Parsa, A., Gao, XY., Yang, Q., Smith, AV., O'Connell, JR., Li, M., Schmidt, H., Tanaka, T., Isaacs, A., Ketkar, S., Hwang, SJ., Johnson, AD., Dehghan, A., ... Fox, CS. (2010). New loci associated with kidney function and chronic kidney disease. Nature Genetics, 42(5), 376-U34. https://doi.org/10.1038/ng.568

@article{65f2ff2b31414a9398eba151d01d2ede,

title = "New loci associated with kidney function and chronic kidney disease",

abstract = "Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creat-inine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/ 1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.",

author = "A Kottgen and C Pattaro and CA Boger and C Fuchsberger and M Olden and NL Glazer and A Parsa and XY Gao and Q Yang and AV Smith and JR O'Connell and M Li and Hel{\'e}na Schmidt and T Tanaka and Aaron Isaacs and S Ketkar and SJ Hwang and AD Johnson and Abbas Dehghan and A Teumer and G Pare and EJ Atkinson and T Zeller and K Lohman and MC Cornelis and NM Probst-Hensch and F Kronenberg and A Tonjes and C Hayward and T Aspelund and G Eiriksdottir and Launer, {LJ (Lenore)} and TB Harris and E Rampersaud and BD Mitchell and DE Arking and E Boerwinkle and Maksim Struchalin and M Cavalieri and A Singleton and F Giallauria and J Metter and Boer, {IH (Ian)} and T Haritunians and T Lumley and D Siscovick and BM Psaty and M.C. Zillikens and Ben Oostra and M Feitosa and M Province and {de Andrade}, M and ST Turner and A Schillert and A Ziegler and PS Wild and RB Schnabel and S Wilde and T Munzel and TS Leak and T Illig and N Klopp and C Meisinger and HE Wichmann and W Koenig and L Zgaga and T Zemunik and I Kolcic and C Minelli and FB Hu and A Johansson and W Igl and G Zaboli and SH Wild and AF Wright and H Campbell and D Ellinghaus and S Schreiber and YS Aulchenko and Janine Felix and Fernando Rivadeneira and Andr{\'e} Uitterlinden and Bert Hofman and M Imboden and D Nitsch and A Brandstatter and B Kollerits and L Kedenko and R Magi and M Stumvoll and P Kovacs and M Boban and S Campbell and K Endlich and H Volzke and HK Kroemer and M Nauck and U Volker and O Polasek and V Vitart and S Badola and AN Parker and PM Ridker and SLR Kardia and S Blankenberg and YM Liu and GC Curhan and A Franke and T Rochat and B Paulweber and I Prokopenko and Wang, {W (Wei)} and V Gudnason and AR Shuldiner and J Coresh and R Schmidt and L Ferrucci and MG Shlipak and Cornelia Duijn and I Borecki and BK Kramer and I Rudan and U Gyllensten and JF Wilson and JCM Witteman and PP Pramstaller and R Rettig and N Hastie and DI Chasman and WH Kao and IM Heid and CS Fox",

year = "2010",

doi = "10.1038/ng.568",

language = "Undefined/Unknown",

volume = "42",

pages = "376--U34",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "5",

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Kottgen, A, Pattaro, C, Boger, CA, Fuchsberger, C, Olden, M, Glazer, NL, Parsa, A, Gao, XY, Yang, Q, Smith, AV, O'Connell, JR, Li, M, Schmidt, H, Tanaka, T, Isaacs, A, Ketkar, S, Hwang, SJ, Johnson, AD, Dehghan, A, Teumer, A, Pare, G, Atkinson, EJ, Zeller, T, Lohman, K, Cornelis, MC, Probst-Hensch, NM, Kronenberg, F, Tonjes, A, Hayward, C, Aspelund, T, Eiriksdottir, G, Launer, LJ, Harris, TB, Rampersaud, E, Mitchell, BD, Arking, DE, Boerwinkle, E, Struchalin, M, Cavalieri, M, Singleton, A, Giallauria, F, Metter, J, Boer, IH, Haritunians, T, Lumley, T, Siscovick, D, Psaty, BM, Zillikens, MC, Oostra, B, Feitosa, M, Province, M, de Andrade, M, Turner, ST, Schillert, A, Ziegler, A, Wild, PS, Schnabel, RB, Wilde, S, Munzel, T, Leak, TS, Illig, T, Klopp, N, Meisinger, C, Wichmann, HE, Koenig, W, Zgaga, L, Zemunik, T, Kolcic, I, Minelli, C, Hu, FB, Johansson, A, Igl, W, Zaboli, G, Wild, SH, Wright, AF, Campbell, H, Ellinghaus, D, Schreiber, S, Aulchenko, YS, Felix, J , Rivadeneira, F , Uitterlinden, A , Hofman, B, Imboden, M, Nitsch, D, Brandstatter, A, Kollerits, B, Kedenko, L, Magi, R, Stumvoll, M, Kovacs, P, Boban, M, Campbell, S, Endlich, K, Volzke, H, Kroemer, HK, Nauck, M, Volker, U, Polasek, O, Vitart, V, Badola, S, Parker, AN, Ridker, PM, Kardia, SLR, Blankenberg, S, Liu, YM, Curhan, GC, Franke, A, Rochat, T, Paulweber, B, Prokopenko, I, Wang, W, Gudnason, V, Shuldiner, AR, Coresh, J, Schmidt, R, Ferrucci, L, Shlipak, MG, Duijn, C, Borecki, I, Kramer, BK, Rudan, I, Gyllensten, U, Wilson, JF, Witteman, JCM, Pramstaller, PP, Rettig, R, Hastie, N, Chasman, DI, Kao, WH, Heid, IM & Fox, CS 2010, 'New loci associated with kidney function and chronic kidney disease', Nature Genetics, vol. 42, no. 5, pp. 376-U34. https://doi.org/10.1038/ng.568

TY - JOUR

T1 - New loci associated with kidney function and chronic kidney disease

AU - Kottgen, A

AU - Pattaro, C

AU - Boger, CA

AU - Fuchsberger, C

AU - Olden, M

AU - Glazer, NL

AU - Parsa, A

AU - Gao, XY

AU - Yang, Q

AU - Smith, AV

AU - O'Connell, JR

AU - Li, M

AU - Schmidt, Heléna

AU - Tanaka, T

AU - Isaacs, Aaron

AU - Ketkar, S

AU - Hwang, SJ

AU - Johnson, AD

AU - Dehghan, Abbas

AU - Teumer, A

AU - Pare, G

AU - Atkinson, EJ

AU - Zeller, T

AU - Lohman, K

AU - Cornelis, MC

AU - Probst-Hensch, NM

AU - Kronenberg, F

AU - Tonjes, A

AU - Hayward, C

AU - Aspelund, T

AU - Eiriksdottir, G

AU - Launer, LJ (Lenore)

AU - Harris, TB

AU - Rampersaud, E

AU - Mitchell, BD

AU - Arking, DE

AU - Boerwinkle, E

AU - Struchalin, Maksim

AU - Cavalieri, M

AU - Singleton, A

AU - Giallauria, F

AU - Metter, J

AU - Boer, IH (Ian)

AU - Haritunians, T

AU - Lumley, T

AU - Siscovick, D

AU - Psaty, BM

AU - Zillikens, M.C.

AU - Oostra, Ben

AU - Feitosa, M

AU - Province, M

AU - de Andrade, M

AU - Turner, ST

AU - Schillert, A

AU - Ziegler, A

AU - Wild, PS

AU - Schnabel, RB

AU - Wilde, S

AU - Munzel, T

AU - Leak, TS

AU - Illig, T

AU - Klopp, N

AU - Meisinger, C

AU - Wichmann, HE

AU - Koenig, W

AU - Zgaga, L

AU - Zemunik, T

AU - Kolcic, I

AU - Minelli, C

AU - Hu, FB

AU - Johansson, A

AU - Igl, W

AU - Zaboli, G

AU - Wild, SH

AU - Wright, AF

AU - Campbell, H

AU - Ellinghaus, D

AU - Schreiber, S

AU - Aulchenko, YS

AU - Felix, Janine

AU - Rivadeneira, Fernando

AU - Uitterlinden, André

AU - Hofman, Bert

AU - Imboden, M

AU - Nitsch, D

AU - Brandstatter, A

AU - Kollerits, B

AU - Kedenko, L

AU - Magi, R

AU - Stumvoll, M

AU - Kovacs, P

AU - Boban, M

AU - Campbell, S

AU - Endlich, K

AU - Volzke, H

AU - Kroemer, HK

AU - Nauck, M

AU - Volker, U

AU - Polasek, O

AU - Vitart, V

AU - Badola, S

AU - Parker, AN

AU - Ridker, PM

AU - Kardia, SLR

AU - Blankenberg, S

AU - Liu, YM

AU - Curhan, GC

AU - Franke, A

AU - Rochat, T

AU - Paulweber, B

AU - Prokopenko, I

AU - Wang, W (Wei)

AU - Gudnason, V

AU - Shuldiner, AR

AU - Coresh, J

AU - Schmidt, R

AU - Ferrucci, L

AU - Shlipak, MG

AU - Duijn, Cornelia

AU - Borecki, I

AU - Kramer, BK

AU - Rudan, I

AU - Gyllensten, U

AU - Wilson, JF

AU - Witteman, JCM

AU - Pramstaller, PP

AU - Rettig, R

AU - Hastie, N

AU - Chasman, DI

AU - Kao, WH

AU - Heid, IM

AU - Fox, CS

PY - 2010

Y1 - 2010

N2 - Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creat-inine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/ 1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

AB - Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creat-inine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/ 1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

U2 - 10.1038/ng.568

DO - 10.1038/ng.568

M3 - Article

C2 - 20383146

SN - 1061-4036

VL - 42

SP - 376-U34

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -