Niertransplantatie: Meer nieren van levende donoren, geïndividualiseerde immunosuppressie en betere resultaten

T. Van Gelder; D. A. Hesselink; J. I. Roodnat; J. N.M. Ijzermans; W. Weimar

Niertransplantatie: Meer nieren van levende donoren, geïndividualiseerde immunosuppressie en betere resultaten

Translated title of the contribution: Kidney transplantation: More kidneys from living donors, individualised immunosuppression and better results

T. Van Gelder^*, D. A. Hesselink, J. I. Roodnat, J. N.M. Ijzermans, W. Weimar

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

In the period 1996-2001, the number of transplanted postmortal kidneys decreased from 425 to 380, while at the same time the number of kidneys transplanted from living donors increased from 81 in 1996 to 155 per year in 2001.

There was a striking increase in the proportion of living non-related donors (59/155).

Although the short-term results of kidney transplantation have improved, and kidneys are very rarely lost as a consequence of acute rejection, the average life of a transplanted kidney has scarcely improved.

Chronic allograft dysfunction is now the major cause of transplant loss. This process is hardly influenced by the immunosuppressive drugs currently used.

To improve the cardiovascular risk profile, several centres discontinue the use of cyclosporin, tacrolimus or prednisone at 6 or 12 months after transplantation or substitute these with other drugs. This is complicated by acute rejection episodes in 10-20% of patients.

With the arrival of a number of new immunosuppressive drugs the risk of rejection might be reduced.

Translated title of the contribution	Kidney transplantation: More kidneys from living donors, individualised immunosuppression and better results
Original language	Dutch
Pages (from-to)	955-959
Number of pages	5
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	147
Issue number	20
Publication status	Published - 20 May 2003

Research programs

EMC MM-04-39-05
EMC MM-04-47-07

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https://www.ntvg.nl/artikelen/niertransplantatie-meer-nieren-van-levende-donoren-geindividualiseerde-immunosuppressie

Cite this

Van Gelder, T., Hesselink, D. A., Roodnat, J. I., Ijzermans, J. N. M., & Weimar, W. (2003). Niertransplantatie: Meer nieren van levende donoren, geïndividualiseerde immunosuppressie en betere resultaten. Nederlands Tijdschrift voor Geneeskunde, 147(20), 955-959. https://www.ntvg.nl/artikelen/niertransplantatie-meer-nieren-van-levende-donoren-geindividualiseerde-immunosuppressie

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title = "Niertransplantatie: Meer nieren van levende donoren, ge{\"i}ndividualiseerde immunosuppressie en betere resultaten",

abstract = "In the period 1996-2001, the number of transplanted postmortal kidneys decreased from 425 to 380, while at the same time the number of kidneys transplanted from living donors increased from 81 in 1996 to 155 per year in 2001. There was a striking increase in the proportion of living non-related donors (59/155). Although the short-term results of kidney transplantation have improved, and kidneys are very rarely lost as a consequence of acute rejection, the average life of a transplanted kidney has scarcely improved. Chronic allograft dysfunction is now the major cause of transplant loss. This process is hardly influenced by the immunosuppressive drugs currently used. To improve the cardiovascular risk profile, several centres discontinue the use of cyclosporin, tacrolimus or prednisone at 6 or 12 months after transplantation or substitute these with other drugs. This is complicated by acute rejection episodes in 10-20% of patients. With the arrival of a number of new immunosuppressive drugs the risk of rejection might be reduced.",

author = "{Van Gelder}, T. and Hesselink, {D. A.} and Roodnat, {J. I.} and Ijzermans, {J. N.M.} and W. Weimar",

year = "2003",

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language = "Dutch",

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Van Gelder, T , Hesselink, DA , Roodnat, JI , Ijzermans, JNM & Weimar, W 2003, 'Niertransplantatie: Meer nieren van levende donoren, geïndividualiseerde immunosuppressie en betere resultaten', Nederlands Tijdschrift voor Geneeskunde, vol. 147, no. 20, pp. 955-959. <https://www.ntvg.nl/artikelen/niertransplantatie-meer-nieren-van-levende-donoren-geindividualiseerde-immunosuppressie>

TY - JOUR

T1 - Niertransplantatie

T2 - Meer nieren van levende donoren, geïndividualiseerde immunosuppressie en betere resultaten

AU - Van Gelder, T.

AU - Hesselink, D. A.

AU - Roodnat, J. I.

AU - Ijzermans, J. N.M.

AU - Weimar, W.

PY - 2003/5/20

Y1 - 2003/5/20

N2 - In the period 1996-2001, the number of transplanted postmortal kidneys decreased from 425 to 380, while at the same time the number of kidneys transplanted from living donors increased from 81 in 1996 to 155 per year in 2001. There was a striking increase in the proportion of living non-related donors (59/155). Although the short-term results of kidney transplantation have improved, and kidneys are very rarely lost as a consequence of acute rejection, the average life of a transplanted kidney has scarcely improved. Chronic allograft dysfunction is now the major cause of transplant loss. This process is hardly influenced by the immunosuppressive drugs currently used. To improve the cardiovascular risk profile, several centres discontinue the use of cyclosporin, tacrolimus or prednisone at 6 or 12 months after transplantation or substitute these with other drugs. This is complicated by acute rejection episodes in 10-20% of patients. With the arrival of a number of new immunosuppressive drugs the risk of rejection might be reduced.

AB - In the period 1996-2001, the number of transplanted postmortal kidneys decreased from 425 to 380, while at the same time the number of kidneys transplanted from living donors increased from 81 in 1996 to 155 per year in 2001. There was a striking increase in the proportion of living non-related donors (59/155). Although the short-term results of kidney transplantation have improved, and kidneys are very rarely lost as a consequence of acute rejection, the average life of a transplanted kidney has scarcely improved. Chronic allograft dysfunction is now the major cause of transplant loss. This process is hardly influenced by the immunosuppressive drugs currently used. To improve the cardiovascular risk profile, several centres discontinue the use of cyclosporin, tacrolimus or prednisone at 6 or 12 months after transplantation or substitute these with other drugs. This is complicated by acute rejection episodes in 10-20% of patients. With the arrival of a number of new immunosuppressive drugs the risk of rejection might be reduced.

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M3 - Article

C2 - 12784528

SN - 0028-2162

VL - 147

SP - 955

EP - 959

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

IS - 20

ER -

Niertransplantatie: Meer nieren van levende donoren, geïndividualiseerde immunosuppressie en betere resultaten

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