No Associations Between Single Nucleotide Polymorphisms in Corticoid Receptor Genes and Heart Rate and Cortisol Responses to a Standardized Social Stress Test in Adolescents: The TRAILS Study

EMC Bouma; H Riese; IM (Ilja) Nolte; E Oosterom; Frank Verhulst; J Ormel; AJ (A.) Oldehinkel

doi:10.1007/s10519-010-9385-6

No Associations Between Single Nucleotide Polymorphisms in Corticoid Receptor Genes and Heart Rate and Cortisol Responses to a Standardized Social Stress Test in Adolescents: The TRAILS Study

EMC Bouma, H Riese, IM (Ilja) Nolte, E Oosterom, Frank Verhulst, J Ormel, AJ (A.) Oldehinkel

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

17 Downloads (Pure)

Abstract

Previously, sequence variation in the glucocorticoid (GR) and mineralocorticoid (MR) receptor genes (NR3C1 and NR3C2, respectively) have been found to be associated with physiological stress responses to social stress tests in small samples of adult men and oral contraceptives (OC) using women. Associations between single nucleotide polymorphisms (SNPs) in the GR (23EK-rs6190, 9beta-rs6198, BclI-rs4142324) and the MR gene (I180V-rs5522 and -2G/C (rs2070951) with cortisol and heart rate responses to a performance-related social stress task (public speaking and mental arithmetic) were examined in a large sample (n = 553) of adolescents (15-17 years). To make comparisons with previous findings, associations were tested in boys (n = 277), free-cycling (FC) girls (n = 183) and OC users (n = 93). None of the previously reported associations in adults could be replicated in this large adolescent sample. Explanations for non-replication are discussed.

Original language	Undefined/Unknown
Pages (from-to)	253-261
Number of pages	9
Journal	Behavior Genetics
Volume	41
Issue number	2
DOIs	https://doi.org/10.1007/s10519-010-9385-6
Publication status	Published - 2011

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Bouma, EMC., Riese, H., Nolte, IM., Oosterom, E., Verhulst, F., Ormel, J., & Oldehinkel, AJ. (2011). No Associations Between Single Nucleotide Polymorphisms in Corticoid Receptor Genes and Heart Rate and Cortisol Responses to a Standardized Social Stress Test in Adolescents: The TRAILS Study. Behavior Genetics, 41(2), 253-261. https://doi.org/10.1007/s10519-010-9385-6

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abstract = "Previously, sequence variation in the glucocorticoid (GR) and mineralocorticoid (MR) receptor genes (NR3C1 and NR3C2, respectively) have been found to be associated with physiological stress responses to social stress tests in small samples of adult men and oral contraceptives (OC) using women. Associations between single nucleotide polymorphisms (SNPs) in the GR (23EK-rs6190, 9beta-rs6198, BclI-rs4142324) and the MR gene (I180V-rs5522 and -2G/C (rs2070951) with cortisol and heart rate responses to a performance-related social stress task (public speaking and mental arithmetic) were examined in a large sample (n = 553) of adolescents (15-17 years). To make comparisons with previous findings, associations were tested in boys (n = 277), free-cycling (FC) girls (n = 183) and OC users (n = 93). None of the previously reported associations in adults could be replicated in this large adolescent sample. Explanations for non-replication are discussed.",

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Bouma, EMC, Riese, H, Nolte, IM, Oosterom, E, Verhulst, F, Ormel, J & Oldehinkel, AJ 2011, 'No Associations Between Single Nucleotide Polymorphisms in Corticoid Receptor Genes and Heart Rate and Cortisol Responses to a Standardized Social Stress Test in Adolescents: The TRAILS Study', Behavior Genetics, vol. 41, no. 2, pp. 253-261. https://doi.org/10.1007/s10519-010-9385-6

No Associations Between Single Nucleotide Polymorphisms in Corticoid Receptor Genes and Heart Rate and Cortisol Responses to a Standardized Social Stress Test in Adolescents: The TRAILS Study. / Bouma, EMC; Riese, H; Nolte, IM (Ilja) et al.
In: Behavior Genetics, Vol. 41, No. 2, 2011, p. 253-261.

Research output: Contribution to journal › Article › Academic › peer-review

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AB - Previously, sequence variation in the glucocorticoid (GR) and mineralocorticoid (MR) receptor genes (NR3C1 and NR3C2, respectively) have been found to be associated with physiological stress responses to social stress tests in small samples of adult men and oral contraceptives (OC) using women. Associations between single nucleotide polymorphisms (SNPs) in the GR (23EK-rs6190, 9beta-rs6198, BclI-rs4142324) and the MR gene (I180V-rs5522 and -2G/C (rs2070951) with cortisol and heart rate responses to a performance-related social stress task (public speaking and mental arithmetic) were examined in a large sample (n = 553) of adolescents (15-17 years). To make comparisons with previous findings, associations were tested in boys (n = 277), free-cycling (FC) girls (n = 183) and OC users (n = 93). None of the previously reported associations in adults could be replicated in this large adolescent sample. Explanations for non-replication are discussed.

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